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Biomedical subjects

V Wildenhahn

Publications and source records attributed to V Wildenhahn.

9 recordsLinked to original sources

[Glucocorticosteroid, catecholamine and protein-bound iodine (PBI) plasma levels in swine following electrocutaneous stimulation].

Application of electrocutaneous stimuli for short-time excitation of swine, accompanied by high locomotor activity, led in animals weighing between 30 kg and 45 kg to steep rises of catecholamine and glucocorticosteroid plasma concentrations, while little change was recordable from protein-linked iodine. Increase in plasma glucose and RQ in animals with higher rises in plasma-borne catecholamines and glucocorticoids was higher than that in animals with lower catecholamine deflection. Both the results reported in this paper and findings obtained from other studies into swine are likely to suggest major involvement of the sympathico-adrenomedullary system in the buildup of transport stress. Interdependence was found to exist between the intensity of the adrenergic reaction, on the one hand, and rises in plasma glucose and RQ as well as drop of pH, on the other. Those findings from various tests seem to support the conclusion that under conditions of severe excitation and high locomotor activity the differentiated resistance of swine to stress is atributable to different intensities of sympathico-adrenergic reaction of the animal concerned.

11-Hydroxycorticosteroids

[Plasma concentration curves of catecholamines and corticosteroids as well as PBI in swine kept under various conditions and acutely exposed to cold].

The response to acute cold (-5 degrees C) of swine kept single was found to differ from that of animals kept in groups. Such difference in reaction was reflected in significant variation of plasma concentration curves in catechol amines and 11-OHKS during and after acute exposure to cold. The response to cold stimulation of animals kept single was primarily and pronouncedly via the sympathicoadrenal system, whereas animals kept in groups responded to acute cold exposure, with the hypothalamic-adrenocortico-pituitary system playing the major role. Significant rise in PBJ in response to 30 and 90 minutes of exposure to cold was recorded only from animals kept single and interpreted as an expression of strong adrenergic reaction of such probands. Such difference in response to one and the same acute stimulus supported the conclusion that there was a difference in adaptation capacity between animals in those two keeping conditions. The results also suggested that type and degree of organic response to a specific stimulus were likely to depend not only on the intensity of the given stimulus, but also on the control potential produced by all closely interconnected control circuits at the time of stimulation.

Adrenal Cortex Hormones

[Effect of noise on the physiological functions in fowl. 1. Effect of primary strong noise on the 11-OHKS level in broilers and leghorns].

The effects of first noises on broilers and white leghorns were tested by plasma levels on 11-hydroxycorticosteroid (11-OHKS). The noises were 100 dB, 60 to 8,00 Hz, and applied 30 minutss to one group of broilers, aged 14, 28, and 56 days, and to another group of broilers and white leghorns in adult age. The reactions were compared. Acoustic stimulation was followed by temporary activation of the hypothalamic pituitary-suprarenal system. The rise of the plasma glucocorticosteroid level in leghorns was three times as high as that in adult broilers, which was interpreted as a reflection of stronger organic stress. Reactions differed in intensity, depending on age as well. Plasma-11-OHKS levels went up by 32 per cent maximum in broilers aged 56 days or by 73 per cent in animals aged 14 days or 120 per cent in those aged 28 days. The above results seemed to support the conclusion that noises of the above quantity and quality represented stress on fowl.

11-Hydroxycorticosteroids

[Effect of noise on the physiological functions in fowl. 2. Adaptation to noise of white leghorns and broilers].

Two experimental groups and series were compared (leghorns and broilers as well as two age groups of broilers) for their adaptive responses to repeated noise application. The noise was 100 dB and applied daily 30 minutes. The reference for comparison was the plasma-11-hydroxycorticosteroid concentration (11-OHKS). The results differed somewhat from those obtained earlier from one first short-time noise application, in that the rise in plasma glucocorticosteroid concentrations dropped from 431 to 210 per cent of the initial values in adult leghorns exposed to repeated noise stress over seven days. Adult broilers, however, did not exhibit any difference in the magnitude of rise of 11-OHKS concentrations by comparison between first and seven days of repeated stress. The initial values, however, were reached earlier by repeated noise application.

11-Hydroxycorticosteroids

[Effect of noise on the physiological functions in fowl. 3. Effects of primary and repetitive acoustic stimulation on glucose and free-fatty-acid plasma levels in broilers of different age groups].

The effects of first and repetitive noise applications to broilers, aged 14, 28, and 56 days, were tested by the responses of the energetic substrates plasma glucose concentration and free fatty acids. The plasma concentrations of glucose and free fatty acids in broilers at slaughter age with no exposure to noise were higher than those in younger animals. Regular daily noise application of 100 dB, 60 to 8,000 Hz, for 30 minutes, which began on the first day of age, led to rises in the plasma glucose levels of animals aged 56 and 28 days even prior to renewed acoustic stimulation, which obviously was a conditioned reflex. Such rises were accompanied by decline in plasma concentrations of free fatty acids, which phenomenon was attributed to higher initial values of plasma glucose. First as well as repetitive noise application led to changes in the plasma content of energetic substrates. Both the direction and magnitude of the reaction appeared to depend on the given initial value. The plasma level responses of glucose and free fatty acids were opposite to one another in all animals, 56 days of age, which were exposed to repeated noise.

Acoustic Stimulation

[Effect of long-lasting noise on the plasma concentration of catecholamines, glucocorticosteroids and PBI in pigs].

Exposure of pigs with a body mass of 25-30 kg to long-lasting motor noise (108 dB, 60-8000 Hz, 72 hours) results in a considerable increase of catecholamine concentration in the plasma. Coincidently there is a sharp continuous decrease of the 11-OHKS in the plasma during the whole period of exposure to noise. Immediately after stopping the acoustic irritation the concentration of plasma corticosteroids increases again. The electroencephalogram (EEG) giving evidence of inhibition signs during exposure to noise an adaptation effect of the information processing system is concluded. The increase of the PBJ during the period of acoustic stress points to an increased function of the thyroid gland but simultaneously it is considered to be an expression of the elevated adrenergic situation. By reason of the strong deviation of the three observed regulatory systems must be concluded that longer-lasting exposure to noise with the applied quality and intensity represents a stress situation for pigs having noise character as established for men. A possible influence on the productivity of the pork type pig by permanent acoustic stress is indicated.

11-Hydroxycorticosteroids

[The course of plasma concentrations of cathecholamines and corticosteroids and of plasma--bound iodine (PBJ) in swine under the effect of noise and of various methods of raising].

Plasma concentrations of 11-OHKS were transitorily increased with significance in pigs, 25 kg to 45 kg in live weight, exposed to short-time engine noise (120 dB, 60 to 8,000 Hz, 60 minutes). Intensity of noise application and duration did not cause significant variation of plasma concentrations in catecholamines nor in P.B.J. The catecholamines were on a rising trend. Those results supported the conclusion that both quality and quantity of applied noise are perceived by store pigs as factors of disturbance. Their noise nature is comparable to that perceived by man and laboratory animals. Decline in 11-OHKS after 55 minutes of exposure to noise was recorded also by other authors who had exposed other species to long-time noise. It seems to reflect adaptation mechanisms in the information-processing system. The reactivity to noise of the adrenal cortext of swine was found to depend on the form of keeping. Animals kept in groups responded to noise in the same way in which they would respond to acute cold, by significantly increasing rise of plasma concentrations of 11-OHKS. The above results were taken to support the conclusion that organic response to a specific stimulus depended on the level of each control circuit at the time of stimulation.

Adrenal Cortex Hormones

[Hormone concentrations in the plasma of pigs kept under various husbandry methods].

A comparison of pigs weighing 30-50 kg reared either in groups or in individual cages showed that the management system affected the concentrations of catecholamines, 11-hydroxy corticosteroids and protein-bound iodine. Pigs kept in individual cages showed high concentrations of catecholamines and iodine, and low concentrations of corticosteroids. Pigs kept in groups showed high corticosteroids and low catecholamines and protein-bound iodine. The values for hormone concentrations in caged pigs were similar to those reported for the Poland China breed, which are not very resistant to stress produced by temperature and restraint.

11-Hydroxycorticosteroids