PubMed Health⌕ Search

Biomedical subjects

V Wils

Publications and source records attributed to V Wils.

9 recordsLinked to original sources
PubMed2006

[Recent findings regarding the treatment of late-onset depression with vascular brain lesions. A literature review].

BACKGROUND: Late-onset depression with vascular brain lesions is showing increased resistance to antidepressive pharmacotherapy. AIM: To give an overview of alternative treatment options. METHOD: We conducted a literature search via PubMed using the key words: 'late-onset depression', 'white matter lesions', 'cerebrovascular pathology' and 'treatment' and thereby a searchfor all available clinical studies about the treatment described in combination with the key words 'vascular depression', or 'late-onset depression' and 'white matter lesions'. RESULTS: Electroconvulsive therapy, repetitive transcranial magnetic stimulation and nimodipine au,gmentation have beneficial effects on vascular depression. CONCLUSION: The treatment options mentioned are promising, but there is a need for further clinical studies.

Age Factors↗
PubMed2001

[Late-life depression and subcortical ischemic white matter lesions].

Late-life depression and cerebral ischemic white matter lesions. Interest in cerebrovascular disease as a risk factor for depression in the elderly has grown in the last few years. Some authors recently have proposed the concept of a 'vascular depression'. In this paper, which presents a selective review of the literature, it is argued that 'vascular depression' is not a nosological entity. However, it has been shown that cerebral white matter lesions, identified using Magnetic Resonance Imaging (MRI) and thought to represent ischemic damage, are related to depression in the elderly. In particular, there is a correlation with late-onset depression. Moreover, these white matter lesions in depressed elderly adults are associated with cognitive impairment, and probably also with a relatively poor response to treatment.

Age Factors↗
PubMed1997

A chromosome 18 genetic linkage study in three large Belgian pedigrees with bipolar disorder.

The contribution of genetic factors to the susceptibility for affective disorders has been firmly established. Recent reports found evidence for a susceptibility locus for affective disorders in 2 regions on chromosome 18. We describe 3 large Belgian pedigrees with multiple patients with affective disorders. Both chromosome 18 regions were investigated in the 3 families, using parametric and nonparametric segregation methods. In the pericentromeric region, all evidence was against a disease gene in our families. Also the data obtained for the distal part of 18q, argue against a genetic susceptibility factor in our sample.

Belgium↗
PubMed1992

[Respiratory disorders caused by tardive dyskinesia in psychogeriatric patients].

Three case reports of antipsychotically induced tardive dyskinesia with prominent respiratory symptoms in elderly behaviourally disturbed patients are presented, followed by a discussion of the clinical picture and treatment of this relatively ill-known condition. It is not uncommon for the respiratory symptoms of tardive dyskinesia to be misdiagnosed as a pulmonary or psychogenic disorder. As an overall satisfactory treatment of tardive dyskinesia does not exist at present, reinstitution or increasing the dose of antipsychotics is sometimes the only effective way to suppress severe dyskinesia.

Aged↗
PubMed1989

Clinical experience with Tc-99m HM-PAO high resolution SPECT of the brain in patients with cerebrovascular accidents.

In order to evaluate the diagnostic contribution of brain SPECT imaging with 99mTc-HMPAO in cerebrovascular disease, we examined 92 stroke cases (144 lesions), 2 hematoma cases and 30 cases with transient neurologic symptoms. Abnormal tracer distribution is visible as zones of either hypoactivity or hyperactivity (border zone hyperemia or luxury perfusion). Remote vascularization changes could also be found (crossed cerebellar diaschisis or ipsilateral cortical perfusion reduction in thalamic or capsula interna lesions). Both X-ray CT and blood flow SPECT have comparable sensitivity in the exploration of cerebral infarction, with detection in, respectively, 89.5% and 87.5% of the lesions. False negative scintitomographic images are frequently recorded in small lacunar infarcts within the basal ganglia and white matter (capsula interna). Some early infarcts and asymmetry of brain perfusion in patients with transient neurologic symptoms are frequently not detected by CT. An additional advantage of blood flow SPECT is its ability to visualize remote blood flow changes and the changing pattern of vascularization of ischemic lesions and their surrounding areas including hyperemia.

Brain↗