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Biomedical subjects

V Zahn

Publications and source records attributed to V Zahn.

At least 37 records · Page 2Linked to original sources
PubMed1978

[Physiology of uterine contractions (author's transl)].

The number of contractions was recorded in 26 healthy primiparae and 28 multiparae from the 25th to 41st week of pregnancy. A remarkable incidence peak was seen around the 32nd week. The number of pregnancy contractions is not sufficient as the only parameter for recognising an impending premature delivery. However, it does represent a valuable aid when taking the anamnesis and portio findings into consideration. The authors consider tocolysis indicated if more than two contractions per hour are recorded as mean value over a period of one week in conjunction with a tendency of the portio to open up, or if more than three contractions are recorded independent of this sign. Taking individual daily into consideration, the relevant limit is three contractions per hour between the 25th and 28th week, and five contractions per hour between the 29th and 32nd week of pregnancy.

Cervix Uteri↗
PubMed1977

Cataract in a fetus at risk for oculo-cerebro-renal syndrome (Lowe).

A high-risk pregnancy for X-linked recessive inherited Lowe's syndrome was terminated due to a male karyotype in the cultured amniotic fluid cells. The eyes of the male fetus showed specific cataracteous changes of the lens. A posterior lenticonus was due to a defect of the lens capsule. The lenses were of normal size. Loss of lens material through a lens capsule defect could account for the small discoid lens usually seen in Lowe's syndrome. Amino acids in amniotic fluid had normal concentrations except lysine and proline which were markedly elevated.

Amino Acids↗
PubMed1977

[Inhibition of uterine contraction in emergencies (author's transl)].

During the first stage of labour 48 parturients were treated with the tocolytic agent TH 1165 a (Fenoterol-hydrobromide) because of danger to the foetus. The product was slowly injected i.v. in doses of 50 mcg (35 pat.) and 25 mcg (9 pat.) and on 4 patients in doses of 35 mcg. We investigated the effects of this therapy on labour, on the mother's and the child's circulation and on the foetal acid-base balance and foetal gas partial pressure. Whilst the different TH 1165a doses were not markedly different in their tocolytic effect, we discovered that side-effects occurred considerably more often and more intensively when higher doses of TH 116A WERE ADMINISTERED. We therefore recommend one i.v. injection of 25 mcg TH 1165a for clinical uterine relaxation in emergencies during labour. To guard against a vena cava compression syndrome, the injection should always be given with the patient in a lateral position. In emergency uterine relaxation the cardiac tocography (supplemented if necessary by micro blood gas analysis) should be monitored. In order tnce-only syringe containing 25 mcg TH1165a.

Blood Gas Analysis↗
PubMed1977

[Tocograph T 500].

Explore the source record for details and available documents.

Equipment and Supplies↗
PubMed1976

[Fetoscopy. A new method in prenatal diagnosis (author's transl)].

Fetoscopes are now being developed which make possible the inspection of human fetuses as well as withdrawal of a fetal blood sample in the early mid-trimester of pregnancy. The preliminary experiences of several groups are presented in this report. In addition, a fetoscopy including fetal blood sampling in a 24 week pregnancy prior to therapeutic abortion is described. The first prenatal diagnoses which have been made using this novel technique, concern defects of the fetal erythrocytes (sickle cel Hb, thalassemia). The fetal blood sample that was obtained in the present case was studied by appropriate methods. As expected, there was no evidence of either of these anomalies.

Anemia, Sickle Cell↗
PubMed1976

[Investigations on the occurrence of mycoplasma in the amniotic fluid (author's transl)].

In order to elucidate the pathogenetic importance of mycoplasma in amnionitis and in infectious syndrome of the amnion, the amniotic fluid of 185 healthy pregnant women was investigated for mycoplasma, bacteria and fungi. In no case mycoplasma were detected. This means that amniotic fluid is normally free of mycoplasma. If mycoplasma occurs in the amniotic fluid it has to be considered as a possible cause of amnionitis and infectious syndrome of the amnion.

Amnion↗
PubMed1975

[Prenatal diagnosis of a case of metachromatic leucodystrophy (author's transl)].

Metachromatic leucodystrophy was diagnosed from cell-free amniotic fluid (marked deficiency of arylsulphatase A) in the 20th week of pregnancy of a woman whose two previous children also had the disease. The pregnancy was immediately terminated. Subsequent amniotic cell culture also revealed a very low arylsulphatase concentration corresponding to the values found in amniotic fluid. An about four-fold increase of metachromatic material was found in the formalin-fixed brain of the aborted fetus.

Abortion, Therapeutic↗
PubMed1975

[Prenatal diagnosis of Sandhoff's disease (GM2-gangliosidosis, type 2)].

The diagnosis of GM2-gangliosidosis type 2 (Sandhoff's disease) was made prenatally (23rd week of pregnancy) by amniocentsis. A sibling with "Tay-Sachs disease" had died shortly before. Severe deficiency of total beta-hexosaminidase was found in amniotic fluid and amnion-cell culture. After interruption of the pregnancy the enzyme defect was also found in the fetal brain tissue and the concentration of ganglioside GM2 was three times normal, confirming the diagnosis.

Amniocentesis↗
PubMed1975

[Prostaglandin F2alpha as a method of choice for interruption of pregnancy (author's transl)].

Since March 1972 we have been applying Prostaglandin F2 alpha in 6 patients between the 8th and 12th week of pregnancy, in 2 patients between the 13th and 16th week, in 16 patients from the 17th week onwards, and in 10 women at term. The intravenous and extraamniotic application of Prostaglandin for interruption of pregnancy has proved a success even in severe general diseases. No severe side effects have been observed. Antidotes are beta-sympathicomimetics as for Oxytocin, too Prostaglandin is a valuable pharmacon in the obstetrical area.

Abortion, Induced↗
PubMed1975

[Partusisten in obstetrics].

Thanks to a tocolytic agent we are no longer helpless against the premature onset of labour. We have achieved very good therapeutic results with the tocolytic agent Th 1165 a (Partusisten). No harmful effects have been observed in mother or child during short- or long-term treatment with Partusisten. Betasympathomimetics are today one of the most important groups of drugs in use in the delivery room. The therapeutic results were considered satisfactory in 152 pregnant women.

Drug Therapy, Combination↗
PubMedDate not supplied

[Holoprosencephaly--clinical picture and genetic counseling in 6 cases].

Inadequate midfacial and forebrain development may result from constitutional chromosome aberrations, gene defects and, possibly, from as yet unidentified terato-genetic agents. The spectrum of clinical manifestations ranges from cyclopia with grossly incomplete organogenesis of the forebrain to apparently minor deviation from normal midface morphogenesis presenting as hypotelorism or absence of the philtrum. Such minor facial dysmorphias may, however, be likewise accompanied by severe anomaly in brain development and function. We report six cases of holoprosencephaly defects in children without demonstrable chromosomal anomalies. The presenting clinical symptoms in these cases were anomalies of cranio-facial shape, hypotelorism; nasal and ocular malformations, as well as median clefts. Some cases presented additional defects in extra craniofacial regions. Two infants who survived for several hours showed evidence of forebrain defects on CT-scans. Three of the cases suggest autosomal-recessive inheritance with 25% recurrence risk on the basis of proven or highly probable parental consanguinity. The remaining, presumably sporadic cases carry a low empirical recurrence risk. Three of the six cases received direct or indirect hormone treatments during early pregnancy.

Abnormalities, Multiple↗