Biomedical subjects
Publications and source records attributed to V Zeman.
Adipose tissue in the thyroid gland was observed in 7 biopsies and 2 autopsies: in 3 cases of solitary adenolipoma, 3 cases of multiple adenolipoma, 1 case of pure lipomatosis and 2 cases of lipomatosis with multiple adenolipomas combined with amyloidosis of lobules as well of adenomas in one bioptic case. Pathogenesis of this unusual phenomenon was discussed.
1. Extreme long-term endurance loads of great intensity lead during the recovery period to significant changes of the preejection period and Weissler's index. The cause of this change is most probably the reversibly impaired contractility of the heart muscle after fatigue of the left ventricle as a result of a certain degree of overburdening. 2. Systolic time intervals are suitable means for the dynamic follow-up of the performance of the left ventricle in subjects after sports performances.
The authors subjected to endoscopic examination 90 patients with duodenal ulcers. From each patient they collected a bioptic specimen of the gastric antrum and duodenal bulbus for microbiological and histological examination. They found that for detection of C. pylori the microscopic examination was most useful. The presence of C. pylori in the gastric antrum was detected in 87% of the subjects and in the duodenal bulb only in 48%. The difference is significant at the 0.01 level. To 43 patients of the group Ranitidine was administered. The ulcer was cured within 4 weeks in 35 subjects. Ranitidine did not affect the presence of C. pylori and antral gastritis. After cure of the ulcer the authors administered Tarivid to 10 patients with persisting C. pylori positivity. The presence of C. pylori and antral gastritis were not affected by this treatment.
The authors present two cases where on the basis of the pilonidal sinus spinocellular carcinoma developed. Both patients were successfully operated. The first one has been for three years, the second one for eight months without relapse. From the paper ensues that cancerization of the pilonidal sinus must be considered a very serious complication and must be prevented by early surgery.
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Whenever we stand upright in apparent static equilibrium, we are, in fact, continuously making minor adjustments in order to maintain our balance. For each intervertebral joint, a point must exist at which all moments applied to the joint are continually and dynamically balanced. This point, known as the centre of reaction, is a mathematical invention necessary to perform analyses of spinal motion, but which need not be associated with any real anatomical structure. As the spine flexes and extends, this centre is expected to move; where it moves and the rationale for its motion is worthy of enquiry. In this paper, we propose that the centre of reaction remains confined to the nucleus of the disc, but only if one simple but crucial assumption is made; that the motion of the spine and control of its musculature maintain a minimum and equal stress at each intervertebral joint. This is a simple hypothesis which imposes a very specific relationship between lordosis and the centre of reaction. We investigate this relationship and its consequences on the teaching of lifting. The impossibility of designing experiments adequately to verify this hypothesis prevents in vivo verification, and, therefore, the model's verification must be made through the inferred consequences. For example, the capability of correctly predicting physiological responses of the musculoskeletal system is an indication of the validity of a model; however, this is not universally accepted. In this particular case, additional experimental data are available in the form of the locus of the centre of rotation of a vertebra vis-à-vis its lower neighbour as the spine flexes and extends. It is instructive to compare the predicted locus of the centre of reaction to experimentally determined locus of the centre of rotation; more than just coincidental similarities are found.
Two groups of patients with less advanced stages of differentiated thyroid cancer were followed from 2 to more than 25 years: 1. 326 patients with preventive thyroid ablation (PTA) in cases of a tumor without lymphatic and remote metastases; 2. 471 patients with lymph node syndrome. It was found that the survival of patients with lymph node syndrome was less including the group below 40 years of age. Within the first group (with PTA) the survival was less in cases with the invasion of tumor through the thyroid capsula (stage T3 according to WHO classification). In both groups neither any significant effect of sex nor histological characteristics of the tumor (i.e. papillary v.s. follicular) was found. However, the effect of age was found to be remarkable in both groups, the prognosis being worse in patients after 40 years of age. Finally, the prognosis of less advanced stages of differentiated cancer was much better than than in patients with remote metastases.
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Noninvasive polygraphic tracings obtained at rest and during isometric hand-grip exercise were analysed in 67 healthy subjects. The purpose of the study was to determine the response of noninvasive polygraphic parameters to isometric exercise. During the third minute of sustained squeezing of a balloon dynamometer (30% of maximal voluntary contraction) a significant increase occurred in heart rate (+16.8 +/- 10.7 beats/min) an increase in both systolic and diastolic blood pressure (+3.4 +/- 1.6 kPa and 2.6 +/- 1.7 kPa respectively), increase in apexcardiographic index 100.a/D (+14.5 +/- 15.0% "D" amplitude), decrease of diastolic amplitude time index square root 2-c/(2-0) X (a/D) (-20.1 +/- 26.5), shortening of pulse transmission time (-0.006 +/- 0.005 s) and prolongation of cardiac cycle length corrected for left ventricular ejection time (+0.011 +/- 0.010 s) discussed. All these changes were statistically significant.
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