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Biomedical subjects

V Zhelev

Publications and source records attributed to V Zhelev.

18 recordsLinked to original sources
PubMed1990

[A familial aggregation of cases with abnormally located chordae in the heart].

Two families with abnormally situated chordae in the heart ventricles are described. This anomaly is found in children as well as in their parents, young persons 19 to 37 years of age, sometimes in older persons. The appearance of this morphologic sign in different generations of the same families and its vertical transmission suggests genetic determination with monogenic autosomal-dominant way of inheritance, but a polygenic inheritance cannot be excluded.

Adult↗
PubMed1989

[Echocardiographic studies in patients with arterial hypertension and above-normal body weight (preliminary report)].

24 echocardiographic parameters were studied in 94 patients with arterial hypertension I and II stage, 25 of the patients were with normal body mass and 65 patients were obese (above normal body mass). Simultaneous M-type and two-dimensional echocardiographic recordings were taken. In the non-obese hypertensive patients the left ventricular hypertrophy was of the concentric type while in the obese hypertensive patients it was of the eccentric type. The correlative analysis between the changes of the echocardiographic parameters and the degree of obesity revealed an exceptionally great correlation with the diastolic and systolic dimensions and the volumes of the left ventricle, the left ventricular muscular mass and its index. The ratio between the left ventricular muscular mass and the left ventricular diastolic volume does not change significantly with the increase of the body mass and could be used for differentiation of the cardiac dilatation which is not due to the increased body mass.

Cardiomegaly↗
PubMed1986

[Case of methyl parathion poisoning in heifers].

A clinical and morphological study was carried out on mass scale poisoning of heifers with methylparathion. Out of a total of 80 animals in a herd 13 heifers died or were forcedly slaughtered within several hours to three days, and other 9 heifers were cured after diagnosing severe methylparathion poisoning. The presence of the preparation was demonstrated chemically in the stomach and intestinal content of the affected animals. The precise lethal dose, however, was not established owing the outbreak of spontaneous poisoning. On the base of literature data and personal investigations it is believed that in the case described the intake of poisonous matter largely surpassed the lethal dose for cattle (20 mg/kg body mass), particularly on the occasion of a peracute course of the disease. Clinically, the intoxication ran its course with troubles on the part of the central and the vegetative nervous systems. Morphologically, there were oedema of the brain and the meninges, oedema and emphysema of the lungs, degeneration processes in the liver and the other parenchymal organs, oedema and hemorrhagic infiltrations in the wall of the rumen, abomasum, and proximal portions of the intestine, and sporadic or numerous hemorrhages in the organs referred to, particularly on the epi- and endo cardium.

Animals↗
PubMed1984

[Pathomorphological changes in the organs of cattle dying in so-called sudden death].

Studied were morphologically the organs of 10 cattle originating from two provinces of Cuba that suddenly succumbed ( muerte subita ). There were hemorrahagic diathesis, and histologically--general activation of the reticulo-endothelial system, nonsuppurative encephalomyocarditis, interstitial nonsuppurative hepatitis, nephritis, and pneumonia as well as catarrhal hemorrhagic gastroenteritis. In all cases there were among the lymphoid proliferations diffusely disseminated eosinophile leukocytes ( hyperergia ). This finding showed that the disease had run a subacute or chronic course which was made acute by the action of some stress factors (continuous running, intoxications oligoelement disturbances, etc.). The finding was also characteristic of reactive processes taking place under the action of some specific virus that probably took part in the etiology of the disease and required an intermediary host that remained unknown at the time.

Animals↗
PubMed1983

[Tumors of the ovaries in zebus].

In a total of 112 slaughtered sterile cows of the Zebu cattle, originating from the Camaguey region, Cuba, 25 tumors were found in 22 animals (in three of the cows the tumors were bilateral). Histologically, the tumors were differentiated as follows: 1 papillary adenoma, 6 papillary cystadenomas, 1 adenocarcinoma, 1 papillary adenocarcinoma, 8 granulosocellular tumors, 1 thecoma, 2 luteomas, 4 hemangiomas, and 1 angiocarcinoma. In two of the cases, beside tumors there were in the ovaries parovarian cysts. The differentiation of the tumors were made on the basis of the international histologic classification of tumors of the World Health Organization. Most frequently, the tumors turned out to be granulosocellular ones as well as papillary cystadenomas and hemangiomas.

Animals↗
PubMed1979

[Chronic progressive interstitial pneumonia in sheep (adenovirus pneumonia)].

Adenoviral infection was established in imported specialized meat strains of sheep Ile de France and Romni marsh. The disease followed a course typical of chronic interstitial progressive pneumonia with reduced tonus, loss of body weight, and high lethality. The disease was serologically proven by the discovery of specific complement binding antibodies in dynamics against the adenovirus. Titers varied from 1 : 2 to 1 : 32. The infestation was reproduced on sheep and lambs by tracheal infection with ultrafiltrate of changed lung tissue and bronchial lymph nodes. Morphologically the infection manifests itself by considerable hypeplastic processes in the lungs and less pronounced ones in the liver and kidneys. The typical changes indicated are accumulation of lymphoid cells and histocytes in the interstitial tissue, as well as adenomatous expansion of alveolar and bronchial epithelium. Considerable cell polymorphism is observed in the alveoles along with presence of gigantic cells and cell syncytia of desquamous epithelial cells, alveolar macrophages and intranuclear inclusions in some of these cells. Complications of Past. Haemolytica with developing catharalsuppurative pneumonia were observed in some cases.

Adenoviridae Infections↗
PubMed1978

[Fibrous suppurative arthritis in sheep].

Described are cases of fibrinous supprative arthritis in sheep characterized by thickenning of the joint, resulting from the involvement of the capsule (periarthritis). Histopathologically, there have been suppurative and necrotic processes combined with fibrinoid necrotizing of the collagen fibers and leukocyte infiltration of the joint capsule. Slight leukocyte infiltration has also been said to occur in the parenchymal organs. Microbiologic studies have revealed the presence of pyogenous bacteria (Corynebacterium pyogenes, Streptococcus pyogenes, Pasteurella multocida).

Animals↗
PubMed1976

[Pathohistological changes in guinea pigs experimentally infected with Yersinia enterocolitica serotype 9].

A total of forty-five guinea pigs were injected subcutaneously with 0.1 cu cm carboneum tetracholoratum each and were infected with Yersinia enterocolitica serotype 9. Part of the animals (31) were treated at the 24th hour following infection with omnopon (a morphine preparation). All infected guinea pigs developed an infectious process manifested by dystrophic and inflammatory changes in the liver, intestine, spleen, lymph nodes and lungs. Those treated with omnopon manifested a more acute infectious process. After the 13--20th day of infection the lesions became more weakly expressed. On the 50th day the inflammatory reaction was observed in the lymph nodes and spleen only. The mortality rate in both groups was about 50 per cent.

Animals↗
PubMed1975

[The pathogenesis of swine plague. The hepato-cerebral syndrome].

A total of 106 pigs were artificially infected with a pathogenic virus of swine fever band were later on killed at the time they had developed a characteristic clinical picture of acute fever. The post-mortem examination revealed that in sixteen animals there was equally expressed hemorrhagic diathesis, five of which had clinical icterus, five manifested subclinical icterus, and six showed no icterus. Histophathologic study was performed of the liver, the cerebrum, the cerebellum, the medulla oblongata and the spinal cord. A correlation was found to exist between the extent to which the lesions had spread in the liver and the cerebrum, especially in the cases manifesting icterus (both clinical and subclinical). It gave grounds to assume that in animals affected with swine fever there exists the so-called cerebrum syndrome as described in the case of some other diseases.

Animals↗