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V Zlatkov

Publications and source records attributed to V Zlatkov.

At least 19 recordsLinked to original sources
PubMed2002

[Significance of the basic oncological principles for the gynecological practice].

The conducted analysis for the place and the role of the oncological principles in the gynecological practice shows, that the implementation of the united oncological doctrine has as a task to provide the necessary quality of diagnostics, treatment and follow-up for these localisations. This doctrine is necessary to be valid for the all levels of health system, while the precondition for her realization appears the standards for the good medical practice and the fulfillment of the requirements of the National health insurance company for the relevant clinical pathways.

Bulgaria↗
PubMed2002

[Assessment of irregular uterine bleeding in premenopausal women].

UNLABELLED: The aim of the present study was to investigate by diagnostic curettage the endometrial histological findings in women with irregular uterine bleeding in premenopause. MATERIALS AND METHODS: Two hundred and thirty women between 40 to 54 wears (mean 48.13) with history of irregular genital bleeding in premenopause were investigated. The classic dilatation and curettage of endometrial cavity was performed and histological results were analyzed. RESULTS AND DISCUSSION: The histological examination of the curettage material shows--normal endometrium in 32 (13.9%) women, anovulatory endometrium in 59 (26.6%), cystic hyperplasia and/or polyposis in 91 (39.6%), atrophic endometrium in 20 (8.7%), atypical hyperplasia in 15 (6.5%), endometrial cancer in 7 (3.1%) women and without adequate material were 6 (2.6%) cases. CONCLUSION: This study pointed out, that women with irregular uterine bleeding in premenopause still remain serious diagnostic and therapeutic problem. Nevertheless, the separate curettage keeps its important role in assessment of health status of these women.

Adult↗
PubMed2001

[Implementation of Reid's colposcopic index in teenagers].

UNLABELLED: The aim of the present investigation was to determine the possibilities of the Reid's colposcopic index to diffentiate the grade of the findings in sexually active teenagers. MATERIAL AND METHODS: The study was based on 83 girls without child-birth in history, aged between 14 an 19 (mean age 18.13 years)q with different grade cytological and/or colposcopic atypia. Colposcopic findings were joined, according to semiobjective Reid's index and the results achieved were compared with the histological findings from the target biopsies. RESULTS AND DISCUSSION: The results from the colposcopic investigation were divided into 4 groups: in group 0--without pathological findings were classified 12 cases, in gr. 1 (Reid)--42, in gr. 2 (Reid)--24 and in gr. 3 (Reid)--5 patients. Histological equivalents were summarized as follow: normal and papiloma epithelium--in 27, CIN I--in 36, CIN II--15q and CIN III--5 cases. CONCLUSIONS: The investigation performed, shows the good correlation (91.6%) between colposcopic impression and histological diagnosis, and this put the question about the place and role of the Reid's colposcopic index in predicting the severity of the pathological changes of the uterine cervix in sexually active adolescent girls.

Adolescent↗
PubMed2001

[Diagnostic modalities of endometrial ultrasonography in women with irregular bleeding in menopause].

UNLABELLED: The aim of the present study was to investigate the diagnostic possibilities of the endovaginal sonography for the assessment of the state of the endometrium in women with irregular bleeding in climax. MATERIALS AND METHODS: Fifty women between 40 to 60 years (mean 47.8) with irregular genital bleeding were investigate. Using transvaginal ultrasound, anterior-posterior, length and width dimensions of the uterus were measured and echostructure of the endometrium was defined. The dilatation and curettage of endometrial cavity was performed subsequently. RESULTS AND DISCUSSION: The histological examination of the curettage material shows - normal endometrium in 15 women, cystic hyperplasian in 16, atrophic endometrium in 11, atypical hyperplasia in 5 and endometrial cancer in 3 women. The correlation of these findings with the results from ultrasound investigation shows, that the degree of the endometrial thickness play a role as a criteria to establish the diagnostic protocol. CONCLUSION: The summarized data from our study shows, that in the limit of 8 mm, the diagnostic accuracy of the method - sensitivity - 75% specificity - 73.8% amd efficacy - 74% give us cause to recommend the transvaginal sonography of the endometrium in women in climax, as a screening tool in the diagnostic protocol for endometrial cancer.

Adult↗
PubMed2001

[Sarcoma of the uterus. Contemporary treatment and diagnostic protocol].

In the presented methodical scheme, consecutively and systematically are scrutinized the epidemiology, the risk factors, the etiopathogenesis, the histopathology and the clinical signs of the uterine sarcoma. The diagnostic possibilities, as well as the staging principles are pointed. The current treatment factors, the prognostic factors and follow-up corresponding to the requirements of the oncological doctrine are presented.

Bulgaria↗
PubMed2000

[Endometrial cancer: a current therapeutic and diagnostic protocol].

In the presented methodical scheme, consecutively and systematically are scrutinised the epidemiology, the risk factors, the etiopathogenesis, the histopathology and the clinical signs of the endometrial cancer. The diagnostic possibilities, as well as the staging principles are pointed. The current treatment tactics, therapeutic schemes according to the stage and follow-up corresponding to the requirements of the oncological doctrine are presented.

Clinical Protocols↗
PubMed2000

[Effectiveness of cervical screening - expectation and reality].

The aim of the present study was to establish the effectiveness of the conducted in Bulgaria cervical screening program for the period 1975-1996. The dynamics of the ratio invasive cancer/in situ cancer, as well as the share of the diagnosed from cytologically signalized women were analyzed. The tendency of deterioration of each of the indices was evident. The crude incidence varies between 12.7 and 22.7 x 10(5) women, while the frequency of CIS is from 3.2 and 6.2 x 10(5) women. This defines unfavorable ratio of the cases with invasive cancer toward CIS, which varies from 2:1 for 1982 to more than 5:1 for 1996 year. The study demonstrates the prevalence of a low rate of confirmed by biopsy, cytologically signalized women--from 15.6% and 30% (total for country--33.3%), except DOD Blagoevgrad--50.6%, Plovdiv--46.4% and Sofia-city--63.8%. The results of our study demonstrate the low effectiveness of to date conducted cervical screening program. The lake of a screening register is another weakness of the program, which lead to a deteriorated registration and reading of the detected precancer lesions, as well as, their diagnostic follow and therapy.

Biopsy↗
PubMed2000

[Cancer of the vulva: modern diagnostic and therapeutic principles].

In the presented methodical sceme, consicutively and systematically are scrutinized the epidemiology. The risk factors, the etiopathogenesis, the hostopathology and the clinical signs of the vulvar cancer. The diagnostic possibilities, as well as the staging principles are pointed. The current treatment tactics, therapeutic schemes according to the stage and follow-up corresponding to the requirements of the oncological doctrine are present.

Antineoplastic Agents↗
PubMed1998

[The screening and diagnosis of ovarian cancer].

The ovarian cancer represents important medico-social problem for our country due to its significant frequency (26.1%) and high mortality (9/1000) among the oncogynecological diseases. The aim of the present review was to discuss the methods--for diagnostics of the ovarian cancer trough analyzing the possibilities for their implementation as a screening in the clinical practice. It is pointed out, that the secondary prophylaxis for ovarian cancer has its place as a selective screening for women with high risk. The proposed scheme includes: gynecological and ultrasound checks up and CA-125 investigation every two year after twenty-five ages of the woman.

Adult↗
PubMed1998

[Cervical screening in Bulgaria. An analysis of the basic indices over the period 1970-1994].

The aim of the present study was to analyze the results from the cervical screening in Bulgaria for the period 1970-1994, by studying the following indicators: incidence, mortality, frequency of carcinoma in situ and stage distribution of the cases with invasive cervical cancer. The relatively constant incidence and mortality until 1987 were evident, after that they shoved increasing and for 1994 they are 19.7% and 7.6% respectively. The similar is the data for the correlation carcinoma in situ/invasive cancer and for the stage distribution of the cervical cancer patients. The obtained results showed, that cervical cancer remain medico-social problem for our country, because the introduced in 1970 cervical cytological screening at the moment is not effective enough.

Bulgaria↗
PubMed1998

[Cytological and histological parallels in atypical colposcopic findings].

The aim of the present study was to analyse the cytological and histological equivalents in 112 patients with atypical colposcopical findings. The results showed the follow distribution of the findings: for cytological examination in 66 of the patients-I gr. PAP, in 32-II gr. PAP, in 6 III-A gr. PAP, in 1-III-B gr. PAP, in 4-IV gr. PAP and in 3-V gr. PAP. The histological study of the obtained target biopsies established: 7 cases with normal epithelium, 82 with different findings of abnormal epithelium with or without nonspecific and specific inflammatory changes; 18 cases with dysplasia from I to III degrees, 2 cases with CIS and 3 with invasive cancer. The degree of correlation of the different findings, as well as the possible causes for hypo and hyperdiagnostic assessments are discussed.

Adult↗
PubMed1998

[The treatment of vaginal infections with Macmiror and Macmiror Complex].

UNLABELLED: The aim of the present study was to examine the therapeutic possibilities of the wide-spectrum medicament Macmiror & Macmiror Complex for the treatment of the vaginal infections. MATERIALS AND METHODS: The study included 52 nonpregnant women among 20 u 54 years (middle age 30.5) with different by kind and intensity colpitis complains. The following microbiological characteristic was established: in 26 cases Candida spp., in 19 Gardnerella vaginalis, in 1 Trichomonas vaginalis and in the rest 6 mixed infection. The treatment of the patients was done in combined scheme: peroral and vaginal administration simultaneously with local treatment of the partner. The control examination was performed bistagely: on 7-10 day and on 30-40 day. RESULTS: The good clinical and microbiological influence of the treated patients was established for the first control examination the effect was found in 89.5% u 84.2% go of the cases with bacterial vaginosis and in 84.6% u 69.2% in those with mycotic colpitis. Relatively high values were found also at the second control, respectively 83.3% and 72.2% for the amine colpitis and 69.5% and 52.2% for vaginal candidosis. The similar favorable influence received also in the rest of the patients. CONCLUSIONS: Our results do show good possibilities of the nifuratel and nystatin combination (Macmiror & Macmiror complex) to influence vaginitis with different etiology, which give us founding to consider, that the drug is suitable for the mixed forms of vaginal infection.

Adult↗
PubMed1997

[Does cytological screening have a place in sexually active teenagers?].

UNLABELLED: The aim of the present investigation is to determine what is the place of cytological screening of the uterine cervix in sexually active teenagers. MATERIAL AND METHODS: The study was based on 83 girls aged between 14 and 19 (mean age 18.13 years) without childbirth in history, who visited our clinic with non-specific gynecological complaints. All patients were submitted to brush cytology applying the classical method and classifying the smears according to the Bethesda system (1991). RESULTS AND DISCUSSION: A high adequacy of the cytologic smears was found, reaching up to 98.8% and the following distribution of the findings according to the various criteria was observed: cells within normal limits in 34.1% of the patients, benign cellular changes due to reactive changes associated with inflammation in 34.1%, atypical epithelial cell abnormalities of undetermined significance in 18.4%, low grade SIL with HPV in 11.0%, without HPV in 1.2% and high grade SIL in 1.2% of thr patients. The role of cytological screening in sexually active adolescent girls is discussed in the context of the obtained results.

Adolescent↗
PubMed1997

[Epithelial changes in the cervix uteri in pregnant women and in cervical oncogenesis].

The changes in the growth and differentiation of the cervical epithelium induced during pregnancy by hormonal influence and anatomical alterations are discussed regarding their magnitude on cervical oncogenesis. Question about the necessity of the self-sufficient centralized reporting of the pregnant women with precancer and cancer lesions is put on.

Cervix Uteri↗
PubMed1996

[Sexual activity, contraception and abortions among teenagers in Bulgaria].

Sexual activity in adolescence, the pregnancies, abortions and deliveries, STDs and the decisive role of the information about sex and sexuality are questions with great importance nowadays. The aim of present study is to find the changes in the sexual activity among the adolescents, in their motivation in beginning the sexual life, information that they have about sex and sexuality, in unwanted pregnancies, deliveries and about abortions in the last five years, following our former study. We present the data obtained from an inquire of 432 schoolboys and girls (aged 17-18), from 263 girls, aged 13 to 18, admitted for interruption of unwanted pregnancy in the Univ. Ob. & Gyn. Hospital in Sofia, Bulgaria, as well as from 132 girls after delivery in adolescence.

Abortion, Legal↗
PubMed1996

[The therapeutic potentials of the vaginal antimicrobial preparation Chlorchinaldin].

The aim of this study is the clinical testing of the vaginal wide-range, antimicrobial, quinolone--Chlorchinaldin/0,2/by POLFA, which has a strong antibacterial, antifungal, trichomonal and keratoplastic effect. The medicine was used on 43 patients with complaints of aggravated fluor. The clinical, colposcopic and microbiologic study showed: candidiasis--in 16 trichomoniasis--in 8, bacterial vaginalis--in 3 and anaerobic vaginitis--in 2 patients. The rest of the women (14) had various aerobic microbial findings. The treatment was daily using one vaginal tablet, every night for 10 days. A control examination was carried out one week after the any of therapy. The results showed a positive clinical effect, since in 67.4% there were negative microbiological findings. The lack of effect in cases with bacterial vaginosis and anaerobic vaginitis was painted out. These results give reason to believe that the wide antimicrobial range of Chlorchinaldin B will be complementary to the currently used drugs in the treatment of vaginal infections.

4-Quinolones↗