The use of steroids in the earlier hypersensitivity stage of schistosomiasis.
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Biomedical subjects
Publications and source records attributed to V de V Clarke.
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Oral oxamniquine at a total dose of 60 mg/kg (given in 4 equal doses morning and evening over 2 days, after food) is an efficient and apparently very safe drug for the treatment of Schistosoma mansoni infections. Lower doses, or shorter schedules of treatment, are less efficient. The drug has little or no effect on S. haematobium infections. Side-effects are mild and infrequent.
The development of large areas of irrigation farming in the south-eastern lowveld of Southern Rhodesia has produced the risk of severe transmission of schistosomiasis over an extent of some 30 000 ha. Control measures instituted by the Ministry of Health were primarily directed against the large and widely distributed snail populations by using molluscicides. The chemical was applied to the irrigation water by drip-feed methods once every 6-8 months. The drains, however, were treated routinely by pairs of rangers searching for snails and applying chemical where they were found. The efficacy of control operations has been assessed by longitudinal studies in children free from infection to determine the incidence of infection. The results indicate that transmission of both Schistosoma haematobium and S. mansoni has been reduced to a level below that measured in areas of the country where irrigation is not practised. The total annual cost for this work was US$ 54 800-55 500.
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