Biomedical subjects

Vítor Sousa

Publications and source records attributed to Vítor Sousa.

5 recordsLinked to original sources

PubMedDate not supplied

[Mediastinal angiofolicular lymphoid hyperplasia--Castleman's disease--case report].

Angiofolicular lymphoid hyperplasia was first described by Castleman as a lymph node hyperplasia characterized by abnormal follicles with small germinal centres and high capillary proliferation. The authors present a case of a 37 year old man with thoracalgy and a mediastinal mass of 4 cm diameter, fleshy and red with a white central area. The diagnosis of plasma cell type of angiofolicular lymphoid hyperplasia in an mediastinal lymph node was made. He also had involvement of two "diaphragmatic" lymph nodes. Angiofolicular lymphoid hyperplasia--Castleman's disease--is a rare lymphoproliferative disease that involves the mediastine or the pulmonary hilus when of solitary form but it can also have other localizations (multicentric or systemic form). Two histological variants are described, the hyaline vascular type and the plasma cell type. IL-6 seems to be in the plasma cell type, due to plasma cells proliferation. Castleman's Disease must be considered in the differential diagnosis of mediastinal masses, namely lymphomas.

Adult↗

PubMedDate not supplied

[Glomic tumor: presentation of an infrequent case].

Glomic tumours are perivascular tumours whose cells resemble modified smooth muscular cells of the glomic body. They are more frequent in the subungueal region and rare in the lung. The authors present a case of a 62 year old women with left thoracic pain and great enforces dyspnoea. She presented a solitary nodule in the external basal segment of the LLL, 1.9 cm diameter, circumscribed, firm and with nodular whitish rose cut surface. Glomic tumours are generally benign. They may origin in ectopic glomic cells or be differentiated from non glomic cells. They should be classified as glomic tumor, glomangioma and glomangiomioma according to the relative abundance of glomic cells and of the vascular and muscular components. Pulmonary metastasis of malignant glomic tumours have been described. In these cases an extra pulmonary primary origin must be excluded. The differential diagnosis of glomic tumours of the lung includes the carcinoid, hemangioperycitoma, smooth muscle tumours (epithelioid leyomioma) and the paraganglioma.

Female↗

PubMedDate not supplied

[Broncho-pulmonary adenomas].

Adenomas of solitary gland type together with papillomas are the true benign tumours in or around the bronchial tree. Alveolar adenoma and papillary adenoma are more frequently observed in peripheral parenchime although this group of tumours is very rare and often incidentally diagnosed. Presenting usually as solitary nodules in adults after 45 years, are easily recognized because of distinct morphology but alveolar adenomas may be difficult to evaluate in frozen sections. Two cases of pleomorphic adenoma and alveolar adenoma are presented and a review of literature is made.

Adenoma↗

PubMedDate not supplied

[Morphological features of the pulmonary sequestration].

The pulmonary sequestration corresponds to pulmonary tissue intra or extra-lobar with systemic arterial nutrition and collateral bronchial ramification. It is infrequent and the intra-lobar identification depends on the correct clinical signs and morphology. The correct study includes imagiologic identification of the systemic artery and morphological characterization of parenchymal changes. These allow identification of abnormal pulmonary parenchyma in intra-lobar cases and were observed using histochemical and immunohistochemical routine methods, both in intra and extra-lobar cases. Four cases of intra-lobar sequestration and four cases of extra-lobar sequestration were studied with application of histochemical techniques--Movat's pentachrome stain and Verhoeff--and immunolabelling with CK7 and TTF1. The parenchymal inflammatory distortion by collagenization was constantly seen as was BALT hyperplasia and pleuritis. By using Movat's pentachrome stain we characterized the sequestration by identifying the artery and the parenchymal changes. The CK7 was useful in the identification of parenchymal damage, together with the antibody anti-TTF1 that had a variable expression, stronger in areas of inflammation because of PII hyperplasia.

Adolescent↗

PubMedDate not supplied

[Congenital cystic adenomatoid malformation of the lung or congenital pulmonary airway malformation].

The cystic adenomatoid malformation of the lung is an hamartomatous lesion, easily identifiable by its morphology through the application of Stocker's et al (1977) classification (type 1, 2 and 3) and also following the criteria of Yousem, to understand the five types dependent on the level of malformation in the airway and lung. The three morphological types described by Stocker were identified in 6 cases of the archive of the Department of Pathology of Coimbra's University Hospital, studied morphologically by the use of Movat's pentachromic stain and the application of the antibody anti-CK7 and anti-body anti-TTF1. In the three morphological types the elastic alveolar net is absent. The CK7 identifies the epithelial distribution and is useful to evaluate the extension of the inflammatory lesion. The antibody anti-TTF1, apparently absent in type 3 cases, is easily identified in type 1 and 2 cases and overexpressed in inflammatory areas. It seems that the absence of cells identified by the antibody anti-TTF1 prevents overdiagnosing of type 4 in Yousem's classification of congenital pulmonary airway malformation (CPAM).

Adolescent↗