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Biomedical subjects

Valery M Dembitsky

Publications and source records attributed to Valery M Dembitsky.

At least 19 recordsLinked to original sources
PubMed2006

Diversity of the fatty acids of the Nostoc species and their statistical analysis.

Low molecular, hydroxy, dioic, saturated and unsaturated fatty acids were determined of six cyanobacterial species belonging to genus Nostoc and in different habitats: freshwater, terrestrial, and as well as symbionts. There are large variations in individual fatty acid contents according to species, and location of the genus Nostoc. Statistical analysis of variability of fatty acids belonging to the genus Nostoc is reported.

Analysis of Variance↗
PubMed2006

Anticancer activity of natural and synthetic acetylenic lipids.

This review is a comprehensive survey of acetylenic lipids and their derivatives, obtained from living organisms, that have anticancer activity. Acetylenic metabolites belong to a class of molecules containing triple bond(s). They are found in plants, fungi, microorganisms, and marine invertebrates. Although acetylenes are common as components of terrestrial plants, fungi, and bacteria, it is only within the last 30 years that biologically active polyacetylenes having unusual structural features have been reported from plants, cyanobacteria, algae, invertebrates, and other sources. Naturally occurring aquatic acetylenes are of particular interest since many of them display important biological activities and possess antitumor, antibacterial, antimicrobial, antifouling, antifungal, pesticidal, phototoxic, HIV-inhibitory, and immunosuppressive properties. There is no doubt that they are of great interest, especially for the medicinal and/or pharmaceutical industries. This review presents structures and describes cytotoxic and anticancer activities only for more than 300 acetylenic lipids and their derivatives isolated from living organisms.

Alkynes↗
PubMed2006

Astonishing diversity of natural surfactants: 7. Biologically active hemi- and monoterpenoid glycosides.

This review article presents 90 hemi- and 188 monoterpenoid glycosides, isolated and identified from plants and microorganisms, that demonstrate different biological activities. These natural bioactive glycosides are good prospects for future chemical preparations from these compounds as antioxidants and as anticancer, antimicrobial, and antibacterial agents. These glycosidic compounds have been subdivided into several groups, including hemiterpenoids; acyclic, monocyclic, and bicyclic monoterpenoids; and iridoid monoterpenoids.

Biological Products↗
PubMed2006

Natural neo acids and neo alkanes: their analogs and derivatives.

This review presents more than 260 naturally occurring (as well as 47 synthesized) neo fatty (carboxylic) acids, neo alkanes, and their analogs and derivatives, isolated and identified from plants, algae, fungi, marine invertebrates, and microorganisms, that demonstrate different biological activities. These natural metabolites are good prospects for future chemical preparations as antioxidants, and also as anticancer, antimicrobial, and antibacterial agents. Described also are some synthetic bioactive compounds containing a tertiary butyl group(s) that have shown high anticancer, antifungal, and other activities. Applications of some neo fatty (carboxylic) acid derivatives in cosmetic, agronomic, and pharmaceutical industries also are considered. This is the first review to consider naturally occurring neo fatty (carboxylic) acids, neo alkanes, and other metabolites containing a tertiary butyl group(s) [or tert-butyl unit(s)].

Alkanes↗
PubMed2006

The colleflaccinosides, two chiral bianthraquinone glycosides with antitumor activity from the lichen Collema flaccidum collected in Israel and Russia.

Colleflaccinosides A and B, two chiral bianthraquinone glycosides from the two geographical varieties of lichen Collema flaccidum collected in Russia and Israel have been isolated as new natural products. Their structures were elucidated using UV, CD, IR, MS, 1D and 2D NMR spectral data, and chemical degradation. The colleflaccinosides B had significant antitumor activity in the crown gall tumor inhibition test.

Agrobacterium tumefaciens↗
PubMed2005

Substances isolated from Mandragora species.

The present state of knowledge in the chemistry of mandragora plant is reviewed. Isolations and identifications of the compounds were done from all parts of this plant. Up-to-date more than 80 substances were identified in different species of the genus Mandragora.

Alkaloids↗
PubMed2005

Astonishing diversity of natural surfactants: 2. Polyether glycosidic ionophores and macrocyclic glycosides.

Polyether glycosidic ionophores and macrocyclic glycosides are of great interest, especially for the medicinal and pharmaceutical industries. These biologically active natural surfactants are good prospects for the future chemical preparation of compounds useful as antibiotics, anticancer agents, or in industry. More than 300 interesting and unusual natural surfactants are described in this review article, including their chemical structures and biological activities.

Anti-Bacterial Agents↗
PubMed2005

Astonishing diversity of natural surfactants: 3. Carotenoid glycosides and isoprenoid glycolipids.

Carotenoid glycosides and isoprenoid glycolipids are of great interest, especially for the medicinal, pharmaceutical, food, cosmetic, flavor, and fragrance industries. These biologically active natural surfactants have good prospects for the future chemical preparation of compounds useful as antimicrobial, antibacterial, and antitumor agents, or in industry. More than 300 unusual natural surfactants are described in this review article, including their chemical structures and biological activities.

Carotenoids↗
PubMed2005

Astonishing diversity of natural surfactants: 4. Fatty acid amide glycosides, their analogs and derivatives.

FA amide glycosides are of great interest, especially for the medicinal and pharmaceutical industries. These biologically active natural surfactants are good prospects for future chemical preparation of compounds useful as antibiotics, anticancer agents, or for industry. More than 200 unusual and interesting natural surfactants, including their chemical structures and biological activities, are described in this review article.

Amides↗
PubMed2005

Astonishing diversity of natural surfactants: 5. Biologically active glycosides of aromatic metabolites.

This review article presents 342 aromatic glycosides, isolated from and identified in plants and microorganisms, that demonstrate different biological activities. They are of great interest, especially for the medicinal and/or pharmaceutical industries. These biologically active natural surfactants are good prospects for the future chemical preparation of compounds useful as antioxidant, anticancer, antimicrobial, and antibacterial agents. These glycosidic compounds have been classified into several groups, including simple aromatic compounds, stilbenes, phenylethanoids, phenylpropanoids, naphthalene derivatives, and anthracene derivatives.

Anthracenes↗
PubMed2005

Astonishing diversity of natural surfactants: 6. Biologically active marine and terrestrial alkaloid glycosides.

This review article presents 209 alkaloid glycosides isolated and identified from plants, microorganisms, and marine invertebrates that demonstrate different biological activities. They are of great interest, especially for the medicinal and/or pharmaceutical industries. These biologically active glycosides have good potential for future chemical preparation of compounds useful as antioxidants, anticancer, antimicrobial, and antibacterial agents. These glycosidic compounds have been subdivided into several groups, including: acridone; aporphine; benzoxazinoid; ergot; indole; enediyne alkaloidal antibiotics; glycosidic lupine alkaloids; piperidine, pyridine, pyrrolidine, and pyrrolizidine alkaloid glycosides; glycosidic quinoline and isoquinoline alkaloids; steroidal glycoalkaloids; and miscellaneous alkaloid glycosides.

Alkaloids↗
PubMed2005

Secondary metabolites of slime molds (myxomycetes).

The compounds reported from the slime molds (myxomycetes) species are described. Almost 100 natural compounds including their chemical structures and biological activities are described in this review article. Only metabolites with a well-defined structure are included.

Alkaloids↗
PubMed2005

Novel antitumor agents: marine sponge alkaloids, their synthetic analogs and derivatives.

Present review describes research on novel natural antitumor agents isolated from marine sponges. More than 90 novel cytotoxic antitumor compounds and their synthetic analogs have shown confirmed activity in vitro tumor cell lines bioassay and are of current interest to NCI for further in vivo evaluation. A great problem, to use directly the reservoir of marine organisms for therapy is the very low availability and the isolation of only very small amounts of the biologically active substances from the natural materials. Thus, the synthetic chemistry is required to develop high yield synthetic methods, which are able to produce sufficient marine alkaloids for a broad biological screening. This review will present some of the aspects of the medicinal chemistry developed recently to introduce such modifications. The structures, origins, synthesis and biological activity of a selection of N-heterocyclic marine sponge alkaloids are reviewed. The emphasis is on compounds poised as potential anticancer drugs: pyrroles, pyrazines, imidazole, and other structural families. With computer program PASS some additional biological activities are also predicted, which point toward new possible applications of these compounds. This review emphasizes the role of marine sponge alkaloids as an important source of leads for drug discovery.

Alkaloids↗
PubMed2005

Myrrh--Commiphora chemistry.

Myrrh and opopanax has been used throughout history in incense and as a perfume. Since Bible times it has been used for the treatment of wounds. The first attempts to identify content compounds were almost 100 years ago. In this review we discuss the present state of knowledge in the chemistry of substances of Commiphora spp.

Commiphora↗
PubMed2004

Astonishing diversity of natural surfactants: 1. Glycosides of fatty acids and alcohols.

Alkyl and fatty acid glycosides have become of great commercial interest in general and specifically for the pharmaceutical, cosmetic, and food industries. Natural surfactants are good sources for future chemical preparation of these glycosides. This review article shows an astonishing diversity of natural surfactants that could be used in laboratories and industry. More than 250 natural surfactants, including their chemical structures and biological activities, are described in this review article.

Biological Factors↗
PubMed2004

Enteridinines A and B from slime mold Enteridium lycoperdon.

Two novel deoxysugar esters, named enteridinines A and B, were isolated from the slime mold Enteridium lycoperdon. Their structures, including the absolute configurations of the hydroxyl and methyl groups, were determined by means of extensive spectroscopic data such as UV, IR, MS, 1D and 2D NMR spectra. Enteridinines A and B have unique structures containing 1,7-dioxaspiro[5.5]undecanes with an O-beta-D-mycarosyl-(1-->4)-beta-D-olivosyl and an O-beta-L-olivomycosyl-(1-->4)-beta-D-amicetosyl-(1-->4)-beta-L-digitoxosyl unit, respectively, and showed growth inhibitory activities against Gram positive bacteria.

Anti-Bacterial Agents↗