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Biomedical subjects

Vicki Lundblad

Publications and source records attributed to Vicki Lundblad.

5 recordsLinked to original sources

The maintenance and masking of chromosome termini.

Telomeres, the natural termini of eukaryotic chromosomes, have been the subject of intense interest during the last decade because of the roles that these chromosome termini perform in both cancer and aging. As we become more cognizant of the consequences of telomere dysfunction on several aspects of human health, significant attention is focused on understanding at a molecular level how the many telomere-associated factors perform their activities.

Cell Cycle Proteins↗

Telomeres in the '80s: a few recollections.

Elizabeth Blackburn, Carol Greider and Jack Szostak were recently recognized with the Lasker award for their work on telomerase and the role of this enzyme in cellular proliferation. Vicki Lundblad reflects on the excitement as these experiments were unfolding.

Animals↗

Telomere replication: an Est fest.

The search for subunits of the telomerase enzyme has uncovered orthologs of the budding years Est1 protein in several species, including humans. Thus, positive regulation of telomerase by Est1 appears to be a widely utilized mechanism for maintaining telomere length homeostasis.

Amino Acid Sequence↗