Biomedical subjects

Viktor I Sevastianov

Publications and source records attributed to Viktor I Sevastianov.

2 recordsLinked to original sources

PubMed2004

Vacuum ultraviolet treatment of polyethylene to change surface properties and characteristics of protein adsorption.

The effects of vacuum ultraviolet (VUV) treatment on surface chemical composition morphology and albumin adsorption for low-density polyethylene (LDPE) and high-density polyethylene (HDPE) were investigated. The attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectra and contact angle measurements indicated the formation of oxygen-containing polar groups and double bonds under VUV photooxidation in the presence of air or under VUV irradiation in vacuum. Scanning electron microscopy revealed the development of regular structure with the period about 1 microm on the surface of LDPE and HDPE during VUV photooxidation. The correlation between amount of tightly adsorbed albumin and surface concentration of carboxyl groups generated by VUV irradiation was found. The aging effect for protein adsorption during long storage of VUV irradiated samples in air or phosphate-buffered saline (PBS) was studied. The obtained results prove the VUV irradiation provides a high potential to regulate protein adsorption on polymers for biomedical applications.

Adsorption↗

PubMed2003

Mathematical model of static platelet adhesion on a solid surface.

The scheme of platelet/surface interaction and a kinetic model of platelet adhesion on a solid surface are suggested. The elaborated approach takes into account the platelet activation by the surface and accumulation of free activated cells in the bulk of the liquid phase. This effect has an especially important role in static experimental conditions. The suggested model explains three types of adhesion kinetic curves, obtained in experiments in vitro: sigmoid curves with or without saturation and an exponential curve with saturation. According to the model, the curve shape is determined by material surface properties, platelet functionality, and experimental conditions of the platelet/surface interaction. The data of static platelet adhesion from platelet rich plasma on glass, siliconized glass, hexadecyltrichlorosilane monolayers, and low-density polyethylene are described mathematically with the proposed model. Numerical parameters are calculated from approximation of experimental data by the model. These parameters allow quantitative characterization of platelet interaction with the material surface.

Biocompatible Materials↗