Biomedical subjects

Vincent M LoLordo

Publications and source records attributed to Vincent M LoLordo.

4 recordsLinked to original sources

PubMed2006

An olfactory biconditional discrimination in the mouse.

Male CD-1 mice were given a biconditional discrimination task with four odors; A, B, C, and D. Mice were presented with odor compounds AC+, BD+, BC-, AD- for thirteen days. Pieces of odorized filter paper were placed in the bottom of odor pots and covered with bedding. On reinforced AC and BD trials, sugar was buried in the bedding, and on nonreinforced AD and BC trials no sugar was present. Following training, simultaneous nonreinforced tests were given between AD and AC, and between BC and BD. The mice spent more time digging in the previously reinforced odor compounds than in the previously nonreinforced compounds. In a second experiment, mice were conditioned to dig in AC+ and not BD-. In a subsequent test with the separate elements they dug more in A and C than in B and D, indicating that the biconditional discrimination had not been solved on the basis of complete perceptual blending. The data demonstrate that mice are capable of olfactory configural learning when solving a biconditional discrimination.

Animals↗

PubMed2006

Unconditioned stimulus devaluation effects in nutrient-conditioned flavor preferences.

Experiments with different temporal relations between the conditioned stimulus (CS) and the unconditioned stimulus (US) in conditioning assessed whether US devaluation effects can be obtained after nutrient-conditioned flavor preference learning. One flavor (CScarb) was paired with a carbohydrate, Polycose; a 2nd flavor (CSprot) was paired with a protein, casein; and a 3rd flavor (CS-) was presented by itself. Following conditioning, one of the nutrients was devalued through pairings with lithium chloride in the absence of the CS flavors. In a subsequent 2-bottle test, rats preferred CScarb over CSprot; however, this preference was smaller when the carbohydrate was devalued than when the protein was devalued. Results suggest that CS flavors are able to form associations with the sensory features of nutrient USs under a wide variety of circumstances.

Analysis of Variance↗

PubMed2003

Palatability shifts in taste and flavour preference conditioning.

Changes in palatability of tastes and flavours as a result of flavour preference conditioning were examined. In Experiment 1, when tastes were paired with glucose in a reverse-order differential conditioning paradigm, rats acquired conditioned preferences for CS(+) and displayed more hedonic responses to CS(+) than to CS(-) in a postconditioning taste reactivity test. In Experiment 2, rats that received oral infusions of flavours as CSs during a reverse-order conditioning procedure expressed both palatability shifts and conditioned preferences for CS(+). Rats that received a forward conditioning procedure acquired a preference for CS(+), but the palatability of CS(+) was unchanged. In Experiment 3, hungry rats drank mixtures of a flavour CS and a calorific or sweet tasting reinforcer in a long-exposure conditioning paradigm. When tested hungry, rats preferred CS(+) whether they had acquired flavour-calorie or flavour-taste associations. However, CS(+) became more palatable only for rats that acquired flavour-calorie associations. These results suggest that acquisition of flavour preferences, as measured by 2-bottle tests, may not always be accompanied by enhanced palatability.

Animals↗

PubMed2003

Outcome-specific conditioned inhibition in Pavlovian backward conditioning.

In the present experiments, the outcome specificity of learning was explored in an appetitive Pavlovian backward conditioning procedure with rats. The rats initially were administered Pavlovian backward training with two qualitatively different unconditioned stimulus conditioned-stimulus (US-CS) pairs of stimuli (e.g., pellet --> noise or sucrose --> light), and then the effects of this training were assessed in Pavlovian-to-instrumental transfer (Experiment 1) and retardation-of-learning (Experiment 2) tests. In the transfer test, it was shown that during the last 10-sec interval, the CSs selectively reduced the rate of the instrumental responses with which they shared a US, relative to the instrumental responses with which they did not share a US. The opposite result was obtained when the USs (in the absence of the CSs) were presented noncontingently. In the retardation test, conditioned magazine approach, responding to the CSs was acquired more slowly when the stimulus-outcome combinations in the backward and the forward conditioning phases were the same, as compared with when they were reversed. These results are collectively in accord with the view that Pavlovian backward conditioning can result in the formation of outcome-specific inhibitory associations. Alternative views of backward conditioning are also examined.

Animals↗