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Biomedical subjects

Vinod K Sinha

Publications and source records attributed to Vinod K Sinha.

10 recordsLinked to original sources

Duloxetine for childhood depression with pain and dissociative symptoms.

Over two thirds of people suffering from depression complain of pain with or without reporting psychological symptoms. Physical symptoms are more prevalent among the women, the elderly, the poor, and in children population. Successful treatment of depression in children complicated by pain symptoms constitutes a great clinical challenge. Duloxetine has already emerged as a safe and effective treatment option for adult depressed patients with painful physical symptoms. However, no data exist in literature which suggests use of duloxetine in childhood and adolescent population for the same clinical indication. We report a case documenting successful use of duloxetine in a depressed girl child who also had severe pain and dissociative symptoms.

Antidepressive Agents↗

Intravenous valproate in acute adolescent mania: a preliminary report.

This study evaluated the efficacy and tolerability of intravenous valproate in acute mania in adolescents. Five consecutive patients, meeting the study criteria, were treated with intravenous valproate. Of them, three significantly improved and one had no appreciable improvement. Two out of five patients experienced gastrointestinal and neurological side effects. This preliminary study suggests intravenous valproate is useful and safe to treat acute juvenile mania.

Adolescent↗

Psychopathological dimensions in childhood and adolescent psychoses: a confirmatory factor analytical study.

The present study explored psychopathological dimensions in psychoses of children and adolescents and the distribution of demographic and clinical variables across different psychopathological domains. This study included 101 consecutive patients aged 6-18 years who had a DSM-IV psychotic disorder (schizophrenia and related disorders or mood disorders). Exclusion criteria included presence of organicity, substance use disorders, and any other childhood disorder. Psychopathology was assessed with Scales for Assessment of Positive and Negative Symptoms. Analysis revealed a four-factor model comprising primary negative, secondary negative, manic and paranoid factors. Patients were regrouped into one of the four factors based on their symptomatology. Patients in these four groups differed in education and age of onset and duration of illness. This study confirmed the existence of a factor structure in psychoses of children and adolescents.

Adolescent↗