Biomedical subjects

Volker Teichgräber

Publications and source records attributed to Volker Teichgräber.

3 recordsLinked to original sources

PubMed2006

Percutaneous MR-guided radiofrequency ablation of recurrent sacrococcygeal chordomas.

OBJECTIVE: Radiofrequency ablation is emerging as a therapeutic technique for the treatment of an increasing variety of tumors. Exact visual guidance to the tumor and controlled delivery of energy is pivotal for ablation success. CONCLUSION: Introducing MRI as a guidance technique ideally uses tumor-specific tissue characteristics, allows direct multiplanar reconstruction for precise needle positioning, and permits real-time monitoring and assessment of treatment-induced tissue signal changes to increase the safety of the procedure.

Aged↗

PubMed2005

Ceramide-enriched membrane domains.

Cellular activation involves the re-organization of receptor molecules and the intracellular signalosom in the cell membrane. Recent studies indicate that specialized domains of the cell membrane, termed rafts, are central for the spatial organization of receptors and signaling molecules. Rafts are converted into larger membrane platforms by activity of the acid sphingomyelinase, which hydrolyses raft-sphingomyelin to ceramide. Ceramide molecules spontaneously associate to form ceramide-enriched microdomains, which fuse to large ceramide-enriched membrane platforms. The acid sphingomyelinase is activated by multiple stimuli including CD95, CD40, DR5/TRAIL, CD20, FcgammaRII, CD5, LFA-1, CD28, TNF, the Interleukin-1 receptor, the PAF-receptor, CD14, infection with P. aeruginosa, S. aureus, N. gonorrhoeae, Sindbis-Virus, Rhinovirus, treatment with gamma-irradiation, UV-light, doxorubicin, cisplatin, disruption of integrin-signaling and under some conditions of developmental death. Ceramide-enriched membrane platforms serve the clustering of receptors, the recruitment of intracellular signaling molecules and the exclusion of inhibitory signaling factors and, thus, facilitate signal transduction initiated by the specific stimulus.

Animals↗

PubMed2003

Lineage relationship and protective immunity of memory CD8 T cell subsets.

Memory CD8 T cells can be divided into two subsets, central (T(CM)) and effector (T(EM)), but their lineage relationships and their ability to persist and confer protective immunity are not well understood. Our results show that T(CM) have a greater capacity than T(EM) to persist in vivo and are more efficient in mediating protective immunity because of their increased proliferative potential. We also demonstrate that, following antigen clearance, T(EM) convert to T(CM) and that the duration of this differentiation is programmed within the first week after immunization. We propose that T(CM) and T(EM) do not necessarily represent distinct subsets, but are part of a continuum in a linear naive --> effector --> T(EM) --> T(CM) differentiation pathway.

Animals↗