PubMed Health⌕ Search

Biomedical subjects

Vyv Huddy

Publications and source records attributed to Vyv Huddy.

5 recordsLinked to original sources
PubMed2004

The relationship between antisaccades, smooth pursuit, and executive dysfunction in first-episode schizophrenia.

BACKGROUND: Both oculomotor and neuropsychologic deficits have been used to support the hypothesis that schizophrenia is associated with prefrontal cortex dysfunction, but studies that have specifically investigated the relationships between these deficits have produced inconsistent findings. METHODS: We measured both smooth pursuit and antisaccade performance in a large group (n = 109) of patients with first-episode schizophrenia and a group of matched control subjects (n = 59) and investigated the relationship between performance on these tasks and performance on a range of executive tasks. We additionally explored the relationship between these variables and measures of psychopathology at presentation and duration of untreated psychosis. RESULTS: Antisaccade errors were significantly correlated with spatial working memory performance. Smooth pursuit gain did not correlate with any neuropsychologic measure. There were no reliable correlations between either oculomotor variables and measures of psychopathology and duration of untreated psychosis. CONCLUSIONS: These findings suggest that in schizophrenia working memory and antisaccade performance reflect the same abnormal prefrontal substrates and that smooth pursuit is mediated by a separate neural abnormality.

Adult↗
PubMed2004

N250r: a face-selective brain response to stimulus repetitions.

We investigated event-related brain potentials elicited by repetitions of cars, ape faces, and upright and inverted human faces. A face-selective N250r response to repetitions emerged over right temporal regions, consistent with a source in the fusiform gyrus. N250r was largest for human faces, clear for ape faces, non-significant for inverted faces, and completely absent for cars. Our results suggest that face-selective neural activity starting at 200 ms and peaking at 250-300 ms is sensitive to repetition and relates to individual recognition.

Adolescent↗
PubMed2003

Matching faces for semantic information and names: an event-related brain potentials study.

In face identification, it has been controversial whether or not access to biographical information and to a person's name are mediated by qualitatively different loci. We recorded ERPs while participants saw two successive faces and performed a matching task that either required retrieval of semantic information ("same or different profession?"), or retrieval of the person's name ("same or different number of forename syllables?"). For both tasks, slow ERP activity between the first and the second face was characterized by a prominent right posterior negativity, with the asymmetry being larger for the name than the semantic matching task. ERPs to the second face showed a difference between congruent (matching) and incongruent (mismatching) trials, with more negative ERPs for incongruent trials. In the semantic matching task, these differences were significant between 450 and 550 ms, and resembled an N400, with a maximum negativity over the vertex. In the name matching task, the topography of this congruency effect was qualitatively different from that seen in semantic matching. These findings suggest that different brain substrates mediate the access to semantic and name information.

Adolescent↗
PubMed2002

Generate and test: an alternative route to knowledge elicitation in an implicit learning task.

Three experiments are reported, which examine generation of knowledge in the McGeorge and Burton (1990) invariant learning task. In this task, participants are exposed to 30 four-digit numbers containing an invariant "3". Following this participants then demonstrate a preference for novel numbers containing this invariant over numbers without it. Despite above-chance performance on this pseudo-memory test, participants appear unable to verbalize anything pertinent to the invariant. Here we introduce a novel version of this task, relying on generation of items rather than a preference test. We argue that this new task engages different processing resources, resulting in different patterns of performance. In Experiment 1, invariant learning was demonstrated using a novel fragment completion test. Experiment 2 found that suppressing articulation inhibited learning, implying that this test task accesses phonological knowledge. It is suggested that using the fragment completion test engages different processing resources during test from those in a preference test. Experiment 3 reinforces this position by demonstrating that knowledge appears to transfer across surface features, a result that seems to contradict recent findings by Stadler, Warren, and Lesch (2000). A resolution is offered, drawing on episodic accounts of implicit learning.

Awareness↗