THIO ANALOGS OF CARISOPRODOL (N-ISOPROPYL-2-METHYL-2-PROPYL-1,3-PROPANEDIOL DICARBAMATE).
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Biomedical subjects
Publications and source records attributed to W A SKINNER.
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Oxidation of dl-alpha-tocopherol or its model, 6-hydroxy-2,2,5,7,8-pentamethylchroman, with alkaline ferricyanide yields a variety of products. In addition to the known dimeric keto ether, two new products, compound A, a trimer, and compound B, an isomer of compound A, were ioslated. Ultraviolet and infrared absorption spectra and paper chromatography indicate that compound A might be identical with liver metabolite "O" which results from the addition of alpha-tocopherol to the diet.
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The "alarm" substance of the top smelt, Atherinops affinis (Ayres), has been isolated by extraction with methanol or ether from suffocated top smelt. These concentrated extracts, when introduced into an aquarium containing top smelt, induce a strong alarm reaction in the fish, characterized by rapid swimming, jumping, and often severe seizures. The fact that extracts from white surfperch, Phanerodon furcatus (Girard); surf smelt, Hypomesus pretiosus (Girard); northern anchovy, Engraulis mordox (Girard); or Pacific herring, Clupea pallasi (Valenciennes) caused only mild excitation in the top smelt indicates the species-specificity of the alarm reaction.
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