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W A TABER

Publications and source records attributed to W A TABER.

18 recordsLinked to original sources
PubMed1965

SEQUENTIAL PRIMARY AND SECONDARY SHUNT METABOLISM IN PENICILLIUM CHRYSOGENUM.

Penicillium chrysogenum was grown on a rich medium and on a more sparse medium which favored penicillin production. Mycelia grown on both media were examined for changes in lipid, mannitol, erythritol, glycerol, pentitol, trehalose, and residual mycelium, and the filtrates were examined for penicillin. Penicillin production took place after the bulk of trehalose, polyol, and lipid had accumulated, and hence the sequential pattern of primary and secondary shunt metabolism, as observed in the case of ergot alkaloid production by Claviceps purpurea, was demonstrated in this example of penicillin production.

Cardiovascular Agents↗
PubMed1964

SEQUENTIAL FORMATION AND ACCUMULATION OF PRIMARY AND SECONDARY SHUNT METABOLIC PRODUCTS IN CLAVICEPS PURPUREA.

The fungus Claviceps purpurea was grown on a rich and a limited nutrient medium such that alkaloid was produced after 8 days on the former medium and after 3 days on the latter medium. Cultures grown on both were assayed for the primary shunt metabolic products, polyols, trehalose, lipids, ribonucleic acid, and polyphosphate, and the secondary metabolic product, ergot alkaloid. Although differing considerably in composition, the two media nevertheless allowed formation of both primary and secondary shunt products. In both instances, however, the secondary product, ergot alkaloid, did not form until formation and accumulation of the primary products had ceased and the mycelial content of these products was actually decreasing. In both instances, alkaloid formation took place after the total dry weight of the mycelium had begun to decrease but while the dry weight of the residual, or structural portion of the mycelium, was either constant or increasing. The dilution of labeling in mannitol isolated from mycelia grown on rich medium containing 1,6-C(14)-labeled mannitol was 2.2. Thus, about half of the mycelial mannitol was actually mannitol which had been taken up directly from the medium.

Ascomycota↗
PubMed1955

Polyene antibiotics.

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Anti-Bacterial Agents↗