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Biomedical subjects

W A Weidner

Publications and source records attributed to W A Weidner.

36 records · Page 2Linked to original sources
PubMed1975

The accuracy of liver scanning in the detection of metastatic disease.

Isotopic scanning of the liver to detect hepatic metastases is a commonly used clinical tool in assessing the extent of malignant disease and the proper mode of therapy. Opinions vary widely as to the efficacy of this test. To determine the accuracy of our scanning technique the clinical and laboratory data on 429 patients who had hepatic scans (technetium sulfur colloid) between February 1971 and May 1973 was reviewed. Of these patients, 125 had a confirmatory procedure (needle biopsy - 15, abdominal exploration - 69, autopsy - 41) done within 6 weeks of their scan. Nineteen patients who had negative scans were proven to have hepatic metastases. Fourteen patients had positive scans which could not be substantiated by one or more of the above confirming examinations. Thus the frequency of error was 25%. Regarding other tests - alkaline phosphatase and bilirubin - no better correlation could be made with respect to the presence or absence of metastases. From the data available on this small group of patients the liver scan is sufficiently inaccurate to preclude relying upon it for the selection of therapy in cancer patients. When the presence of hepatic metastases changes the type of therapy a confirmatory laparotomy or biopsy should be considered.

Humans↗
PubMedDate not supplied

Magnetic resonance imaging in leukodystrophies of childhood.

Magnetic resonance imaging (MRI) is particularly valuable in the diagnosis of childhood brain disorders with abnormal myelination because MRI may identify lesions not always seen with x-ray CT scans. We report the clinical and magnetic resonance findings of six children with leukodystrophy. T2 weighted (spin-echo) images disclosed striking asymmetric involvement of cerebral white matter, particularly in periventricular white matter and visual radiations. Calculated T1 values were significantly elevated in the children with leukodystrophy.

Brain↗
PubMedDate not supplied

Dynamic radiography. An evaluation of cardiac motion by the analysis of scattered radiation during fluoroscopy.

A non-invasive technique, utilizing scattered radiation, has been developed to monitor and measure the motion of the epicardial surface during fluoroscopy. A number of dogs were studied using a monitoring device which consists of an X-Ray beam collimator, collimated sodium iodide dectetors and their associated electronics. The detector signals are computer processed to obtain frequency fingerprints of epicardial motion that may, in the future, indicate the condition of the myocardium.

Computers↗