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Biomedical subjects

W Adam

Publications and source records attributed to W Adam.

36 records · Page 2Linked to original sources
PubMed1976

Decreased anion gap associated with monoclonal and pseudomonoclonal gammopathy.

Nine patients with monoclonal and one with pseudomonoclonal gammopathy were found to have a decreased anion gap. Eight of the patients had multiple myeloma, one has plasma cell leukemia and one had chronic active hepatitis. In all of the the decreased anion gap was associated with an increased concentration of IgG greater than 5 g/dl.

Adult↗
PubMed1976

[The EEG in subacute sclerosing panencephalitis (SSPE)].

This article gives an overview of electroencephalographic results obtained in the case of subacute sclerosing panencephalitis. Severe disturbances of background activity have been observed in all patients. Repetitive complexes usually occur transitorily, so that they cannot always be detected in individual cases. Repetitive complexes must be regarded as being typical of the disease, and consideration must be given in this connection to their particular characteristics (repetition frequency, constancy of form, relations to disorders characterized by myoclonus) and the clinical picture.

Adult↗
PubMed1976

[Experiments to study paper for its suitability as sterile wrapping (author's transl)].

A description is given of experiments for the testing of germ density of paper intended for use as sterile wrapping. The generally used storage tests are unsatisfactory. The following procedure is proposed for the testing: The paper specimen is cut into pieces of about 7 X 7 cm and steam-sterilized at 134 degrees C. A number of samples is placed on the bottom of Petri dishes and each paper sample is sprinkled with 5 drops of a 0.1 ml suspension of Staph. aureus in distilled water. After drying, the paper samples are placed underside down on the surface of a blood agar plate so as to ensure complete contact. After about 5 seconds the paper samples are removed and the plates are incubated for 16 hours at 37 degrees C.

Paper↗
PubMed1975

Glutamine transport and metabolism by mitochondria from dog renal cortex. General properties and response to acidosis and alkalosis.

Mitochondria from dog renal cortex were incubated with L-[14Cglutamine. Glutamate metabolism was prevented by inhibitors so that glutamate accumulated either in the mitochondrial matrix space or in the medium. The formation and accumuation of glutamate formed from glutamine and the distribution of glutamine in the mitochondrial fluid spaces were studied. In the matrix space glutamate rapidly reaches levels over 5 times that of glutamine in the medium. A more gradual accumulation occurs in the medium as glutamate is transported out of the mitochondria. Addition of an energy source such as succinate to the medium accelerates glutamate formation. A Km of 0.6 mM appears to govern the reaction at low concentrations of glutamine; at about 4 mM an abrupt change kinetics occurs with a Km of 5 mM above that level. Both NH4+ and glutamate inhibit glutamine metabolism and phosphate stimulates it, but little effect glutamate or phosphate occurs at low levels of these substances. The pH optimum of the reaction is between 7.4 and 7.8. Mersalyl and p-chloromercuribenzoate strongly inhibit glutamate formation; N-ethylmaleimide and bromcresol green have weaker inhibitory actions, and borate increases the reaction rate. In the presence of mersalyl, glutamine is striclly confined to the outer space of mitochondria and none is detectable in the matrix space. Similarly at ) degrees glutamine is confined to the simultaneously determined sucrose or mannitol spaces...

Acidosis↗
PubMed1975

[Supportive care in bone marrow failure. Technical, immunological and clinical advances].

Supportive care with blood component transfusions has greatly improved prognosis in patients with bone marrow failure. This progress has made possible by newly developed techniques for separation of blood cells and by a better understanding of the antigenicity of human blood cells and of immunologic reactions following their transfusion. Transfusion of white cell and platelet-poor red cell preparations prevent alloimmunization to leukocyte and platelet-bound alloantigens, or non-hemolytic transfusion reactions in already alloimmunized patients. Alloimmunization can be circumvened and effective long-term platelet support to thrombocytopenic patients can be provided by matching donor and recipient for HL-A antigens. The place of granulocyte transfusion in clinical therapy has yet to be defined, although their usefulness in infected granulocytopenic patients is suggested by the few studies reported so far.

Antibody Formation↗
PubMed1975

Seasonal differences in drug- and temperature-dependent changes of the sodium transport across the isolated frog skin.

In two series of experiments, one conducted in the spring (May-June) and the other in the fall (September-November), the influence of raising temperature of the medium and of vasopressin, insulin and ethacrynic acid on polarized sodium transport in the epithelium of frog skin in vitro was studied. Net sodium transport was determined electrometrically, and active and passive components of transport by the isotope method. Raising temperature markedly increased both components, as well as net flux and electric potential of the membrane in the spring months, but not in the fall. Regardless of the character and extent of the effect on transport, raising temperature of the medium had no qualitative or quantitative influence on the action of vasopressin, insulin or ethacrynic acid.

Animals↗
PubMedDate not supplied

[Effect of compositional modification of coffee on certain indices of lipid metabolism in healthy volunteers and patients with hyperlipoproteinemia].

An effect of a 14-day drinking of coffee on some blood serum indices of lipid metabolism was investigated in 20 healthy volunteers and 20 patients with hyper lipoproteinemia (type IIb). The study was carried out in two subgroups: healthy volunteers or patients with hyperlipoproteinemia assigned to the first subgroup drank ordinary coffee and patients assigned to the second subgroup drank coffee deprived of irritant substances (4 glasses daily). It was found that ordinary coffee significantly increased total serum cholesterol and decreased serum HDL-cholesterol in healthy volunteers. Such effects were not seen in subgroup drinking coffee deprived of irritant substances. More significant increase in serum total cholesterol and decrease in serum HDL-cholesterol were found in patients with hyperlipoproteinemia. Drinking of modified coffee does not cause any significant changes in serum lipid metabolism. The authors concluded that drinking of the ordinary coffee should be restricted in patients with hyperlipoproteinemia and use of coffee deprived of irritant substances might be recommended to patients with this disease.

Adult↗
PubMedDate not supplied

The effect of coffee deprived of irritant substances upon some indices of lipid metabolism in healthy volunteers and patients with hyperlipoproteinemia.

Effect of 14 days coffee drinking upon some blood serum indices of lipid metabolism was studied on 20 healthy volunteers and 20 patients with hyperlipoproteinemia (type IIb). The study was done in two subgroups: healthy volunteers or patients with hyperlipoproteinemia which had belonged to the first subgroup drank ordinary coffee and the ones which belonged to the second subgroup drank coffee deprived of irritant substances. (4 glasses per day). It was found that in healthy volunteers ordinary coffee had given rise to a significant increase of serum total cholesterol and to a decrease of serum HDL-cholesterol. These changes were not observed in subgroup drinking coffee deprived of irritant substances. More significant rise of serum total cholesterol and decrease of serum HDL-cholesterol were found in patients with hyperlipoproteinemia. Drinking of modified coffee does not cause any significant changes in serum indices of lipid metabolism. The authors concluded that drinking of ordinary coffee should be restricted in patients with hyperlipoproteinemia and coffee deprived of irritant substances might be recommended to patients with this disease.

Adult↗