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Biomedical subjects

W Allen

Publications and source records attributed to W Allen.

At least 37 records · Page 2Linked to original sources
PubMed1988

A mission of love.

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Dental Hygienists↗
PubMed1986

Atypical lesions of the anal mucosa in homosexual men.

Recent studies suggest that there is an increased incidence of squamous cell carcinoma of the anus in male homosexuals, but a precursor lesion has not been identified. We retrospectively analyzed in a blind fashion all anal tissue removed surgically during 1984. Twelve (6.7%) of the 180 specimens from men contained lesions with foci of epithelial atypia. Only one (0.85%) of 118 specimens from women harbored similar atypia. Of seven additional file cases exhibiting atypical anal mucosa, six were from men. Of 14 men with atypical anal lesions whose sexual orientation was known, 11 (79%) were homosexuals. In the 20 cases found to have atypical mucosal lesions, three patterns of atypia were identified, with more than one often occurring in the same specimen. Anal intraepithelial neoplasia (dysplasia) was identified in seven cases (35%) and occurred primarily at the anorectal junction and in anal ducts. Atypical condyloma was found in three cases (15%). A third lesion histologically indistinguishable from Bowen's disease or bowenoid papulosis was found in 12 cases (60%). In ten of these the lesion was adjacent to a condyloma. Although the natural history of these lesions of the anal mucosa is presently unknown, it may resemble that of similar lesions in other anatomic locations.

Adult↗
PubMed1986

Phosphorylcholine bearing components of some helminthic parasites: localization to parasite lipoproteins.

Extracts of various helminthic parasites were studied to determine the molecular carrier of the hapten phosphorylcholine (Pc). Physicochemical studies showed that the carrier was heterogeneous with regard to apparent molecular weight (70,000-greater than 10(6) daltons). Ultracentrifugal analysis of Ascaris suum and Nippostrongylus brasiliensis showed that Pc was associated with low (LDL), high (HDL) and a heterogeneous group of very high density (VHDL) lipoproteins. The majority of Pc was found in the most dense VHDL (d greater than 1.25 g ml-1). The apparent molecular weight and particle diameter of A. suum HDL was 751,000 daltons and 16.2 nm, respectively. The apparent molecular weights and particle diameters of A. suum VHDL ranged from 469,000 to 677,000 daltons and 13.6 to 15.5 nm, respectively. The electrophoretic mobilities of A. suum LDL and HDL were beta and gamma, respectively. A suum VHDL was electrophoretically heterogeneous. It is probable that Pc is associated with the phospholipid phosphatidylcholine.

Animals↗
PubMed1986

Chylous ascites following retroperitoneal lymphadenectomy for granulosa cell tumor of the testis.

We report on an infant with chylous ascites following retroperitoneal lymphadenectomy for granulosa cell tumor of the testis. Granulosa cell tumor of the testis is an extremely rare lesion, with only 8 cases reported previously, including 1 in an infant. Chylous ascites is a rare problem in children and it has been reported in only 92 cases. The options for management of this difficult problem are discussed.

Chylous Ascites↗
PubMed1983

Melanosis coli. Changes in appearance when associated with colonic neoplasia.

In 30 cases of colonic neoplasia associated with melanosis coli, proliferating or neoplastic colonic epithelium was notable within the melanotic colons by virtue of a striking absence of pigmentation. Microscopically this characteristic was found to be due to an absence or diminution of pigment-laden macrophages in the lamina propria underlying such lesions. Therefore, the absence of pigment-laden macrophages can be considered a marker for abnormally proliferating epithelium. This characteristic may denote a cellular or humoral change mediated by macrophages in association with neoplastic epithelium.

Colonic Diseases↗
PubMed1975

Relationship of bioassayable and immunoassayable plasma ACTH and cortisol concentrations in normal subjects and in patients with Cushing's disease.

Plasma ACTH and cortisol concentrations were determined at 5-min intervals over a 3- or 4-h sampling period in 2 normal subjects. Time spans studied were 10:00 AM-1:00 PM, 4:00 PM-8:00 PM, 8:00 PM-11:00 PM, and 4:00 AM-8:00 AM. Similar sampling for 3 h, (onset 9:00-9:30 AM) was performed on 4 patients with Cushing's disease, 3 untreated and 1 in remission following pituitary irradiation. Two of these patients were studied on 2 separate occasions. Plasma ACTH was determined by both immunoassay (I) and bioassay (B). Although in general, these studies demonstrated significant correlation between I-ACTH or B-ACTH concentrations and those of plasma cortisol, a striking finding in both subject categories was the presence of 30- to 50-min episodes during which marked rises in both I- and B-ACTH concentrations occurred without concomittant, or markedly diminished, increments in plasma cortisol concentrations. This could not be explained by biological inactivity of the ACTH, since a highly significant correlation was present between I- and B-ACTH concentrations at all times; r values ranged between 0.86 and 0.98 for normal subjects, and 0.76 and 0.96 for patients with Cushing's disease. The lack of correlation in these episodes also does not appear to be secondary to an 11-beta-hydroxylase block, differences in the rate of change of plasma ACTH concentrations, lack of adrenal "priming" by prior ACTH or incapacity of the adrenal gland to further increase secretion. I/B ACTH ratios were similar in the normal subjects (1.42-1.64) and in the patients with Cushing's disease (1.27-1.47). "Apparent" ACTH half lives calculated from "peaks" of ACTH secretion were 7-12 min for I-ACTH and 3-9 min for B-ACTH in the normal subjects; and 9-13 min and 7-9 min respectively, in the patients with Cushing's disease. Mean plasma ACTH I-and B-concentrations at comparable time periods were higher in patients with active Cushing's disease than in normal subjects. These studies also indicate that in Cushing's disease, the abnormality present resides in ACTH regulatory mechanisms, not in the nature of the ACTH secreted. Approximation of the total amount of immunoassayable ACTH secreted in one normal subject over a 24-h period yielded a value of 73 mug. Total mug/h secreted in the 2 normal subjects were highest in the hour preceding awakening (6:30-7:30 AM; 12.9 and 12.2 mug/h); were 5.3 and 4.0 mug/h between 10:00-11:00 AM, and 1.4 and 1.7 mug/h between 9:00-10:00 PM. In the 3 patients with clinically active Cushing's disease, apparent ACTH secretion between 10:00-11:00 AM varied from 19.2-34.3 mug/h, the magnitude of such secretion being positively correlated with the extent of increased adrenal cortical activity present.

Adrenocorticotropic Hormone↗