Biomedical subjects
W B Dublin
Publications and source records attributed to W B Dublin.
The cochlear nuclei--pathology.
This article is a sequel to one dealing with the anatomy of the cochlear nuclei. It employs the combined peripheral/central approach in reviewing some basic principles of the pathology of central deafness, involving the cochlear nuclei. The combined approach shows the relative status of the cochlear elements and of the superior ventral cochlear nucleus in various conditions. Anoxic encephalopathy, including that of erythroblastosis, involves the stated nucleus but spares the peripheral hearing organ. This, as well as the findings in other conditions, reflects on the employment of amplification or the implantation of electrodes. The spheroid cells, the nerve cells of concern of the superior ventral cochlear nucleus (SVCN), show an anatomic frequency gradient, low ventral to high dorsal. In any case of deafness expected to involve the SVCN and showing an audiogram frequency pattern, the frequency gradient must be included in the pathologic investigation. When the organ of Corti is completely destroyed, the spheroid cells may show transsynaptic atrophy.
Cerebral pseudoatrophy and computed tomography: two illustrative case reports.
The detection of cerebral atrophy in the demented patient is best accomplished by computed tomography (CT). However, CT is a static tool in the evaluation of cerebral disease. Two cases of "pseudoatrophy", one secondary to malnutrition, the other secondary to communicating hydrocephalus, will illustrate the problems in the evaluation of "atrophic" change on the basis of one CT examination alone.
Cytoarchitecture of the cochlear nuclei. Report of an illustrative case of erythroblastosis.
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Detection of calcification in specimens.
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The combined correlated audiohistogram. Incorporation of the superior ventral cochlear nucleus.
The state of the spheroid cells of the superior ventral cochlear nucleus (SVCN) must be accounted for along with that of stria vascularis, hair cells, and spiral ganglion neurons in the development of the combined correlated audiohistogram in cases of sensorineural hearing loss. For the stated evaluation, transverse sections through SVCN are marked off into ventrodorsally progressive zones corresponding to the frequency levels of the audiometric chart, and the loss of spheroid cells in each level is estimated on a percentage basis. The resultant "best fit" of pattern of cell injury with audiometric curve suggests that the anatomic frequency scale of SVCN parallels the logarithmic frequency scale of the standard audiometric chart.
The auditory pathology of anoxia.
A case of anoxic encephalopathy is reported, with study on a whole-auditory-pathways basis, and the method of processing tissues is outlined. Pathologic changes are found throughout the central part of the auditory pathway. The importance of including the superior ventral cochlear nucleus (SVCN) with cochlear structures in correlating findings with audiometric data is supported. The previously advanced tonotopic frequency pattern, with zonal vulnerability, of the spheroid cells of SVCN is supported.