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Biomedical subjects

W B Gunning

Publications and source records attributed to W B Gunning.

18 recordsLinked to original sources
PubMed2000

The assessment of alcohol expectancies in school children: measurement or modification?

AIMS: Earlier research has suggested that measuring children's positive alcohol-related expectancies could have the undesirable side effect of increasing them. This has been reported for an instrument that only measured positive expectancies and used a puppet-reference. The present study investigated whether this increase was still found using an unbiased instrument. Further, it was tested whether the assessment method with puppets influenced children's expectancies. DESIGN: Children were assigned randomly to respond on an unbiased expectancy questionnaire in one of two assessment conditions: with reference to a puppet (P) or without reference to a puppet (Q). One month later, children were again administered one of the two assessment conditions, resulting in four assessment orders (PP, PQ, QP, QQ). SETTING AND PARTICIPANTS: Three hundred and ninety-five second- to fifth-graders were administered one of the two methods in their schools and 260 children were measured a second time, 1 month later. MEASUREMENTS: A questionnaire measuring children's positive and negative expectancies was developed that could be administered with or without a puppet-reference. FINDINGS: A large direct response-effect was found: in the puppet condition, children scored higher on positive but not on negative expectancies. A smaller indirect measurement-effect was found at borderline significance: children who had used the puppet method 1 month earlier had significantly stronger positive expectancies than children who had used the questionnaire earlier. CONCLUSIONS: The present results confirm earlier indications that measuring children's positive expectancies may have the undesirable side effect of increasing them. This can be avoided by measuring children's expectancies with an unbiased questionnaire without a puppet-reference.

Alcohol Drinking↗
PubMed2000

A confirmatory analysis of the hierarchical structure of positive and negative dose-related alcohol expectancies in alcoholics and the associations with family history of alcoholism.

OBJECTIVE: The usefulness of measuring four types of alcohol-outcome expectancies in alcoholics was investigated. METHOD: The investigation was conducted in three steps. First, a measurement model previously fitted in a general population sample was fitted in the present sample of alcoholics, using confirmative factor analysis. In the hierarchical model tested, four types of expectancies are represented as four second-order factors: positive and negative expectancies for a low and for a high dose of alcohol. The model was compared with competing models. Second, a common measurement model was tested for subgroups of alcoholics categorized by gender and family history of alcoholism. Third, using path analysis, the associations were investigated for the four types of expectancies with variables of potential relevance for treatment. A sample of 451 male and female clinically referred alcoholics volunteered to complete a series of questionnaires, including the expectancy questionnaire. RESULTS: Following minor modifications, the measurement model was found to fit adequately in the present sample of alcoholics and across the subsamples. Family history of alcoholism was positively associated with positive expectancies, especially for a high dose of alcohol. This association was mediated by cluster-B personality disorders. CONCLUSIONS: Even though the expectancy questionnaire used here should be refined in several respects, the results demonstrate the usefulness of measuring four types of expectancies in alcoholics.

Adult↗
PubMed1999

Platelet adenylyl cyclase activity as a biochemical trait marker for predisposition to alcoholism.

Previous studies demonstrated a reduced Gs-protein stimulated adenylyl cyclase activity in the brain and blood cells of alcoholics. We investigated this phenomenon in platelets of children of alcoholics (COA), i.e., of children at high risk for the acquisition of alcoholism and (as yet) not regularly consuming alcohol. Gs-protein mediated stimulation of adenylyl cyclase by 30 mM NaF and 50 microM forskolin stimulated adenylyl cyclase activity were assessed in platelet membranes of 23 (male and female) COA and 20 control children. Gs-protein stimulated cAMP production by NaF, unlike that induced by direct stimulation of adenylyl cyclase with forskolin, in platelet membranes of COA was profoundly lower than in platelet membranes of control children. Moreover, such a reduced Gs-protein functioning was only observed in platelet membranes of COA with a multigenerational family history of alcoholism. A reduction of Gs-protein stimulated adenylyl cyclase activity in platelets may represent a sensitive and gender-independent trait marker for predisposition to alcoholism, rather than a state marker for alcoholism.

Adenylyl Cyclases↗
PubMed1998

P3 scalp topography to target and novel visual stimuli in children of alcoholics.

The P3 event-related potential (ERP) component was recorded from 7- to 18-year-old children of alcoholics (COAs, n = 50) and age- and sex-matched control children (n = 50) using a visual oddball paradigm, involving nontarget (76%), target (12%), and novel (12%) stimuli. Topographic maps of P3 and associated scalp current density were obtained to supplement a topographic profile analysis. COAs manifested a smaller amplitude P3 to target stimuli over the centroparietal, parietal, and occipital scalp locations than controls. Also, COAs exhibited a smaller amplitude P3 to novel stimuli over the occipital scalp than controls. There were no significant differences between COAs and controls in the P3 scalp topography, indicating that differences in intracranial source strength rather than in source configuration were responsible for the between-group amplitude differences. Also, no significant group differences were observed in the P3 peak latency or in behavioral performance. These results support the notion that the visual P3 may provide a vulnerability marker of alcoholism.

Adolescent↗
PubMed1998

Is a mild deficit in executive functions in boys related to childhood ADHD or to parental multigenerational alcoholism?

A mild deficit in executive functions has been hypothesized to be associated with attention deficit hyperactivity disorder (ADHD), with externalizing problem behaviors such as conduct disorder (CD) and with the vulnerability to alcoholism in sons of multi-generational alcoholics (SOMGAs). These three categories overlap, which raises concerns about the specificity of the hypothesized associations. In the present study, measures of executive functions (EFs) were tested in seventy-six 7- to 11-year-old boys: boys with ADHD but without a family history of addiction, SOMGAs, and controls. Specific deficits in EFs were found for boys with ADHD but not for SOMGAs. The association between a deficit in EFs and attention problems remained after controlling for externalizing problem behaviors, but not for the reverse. These results suggest that a mild deficit in EFs is specifically related to ADHD and that the deficits reported in boys with CD and in SOMGAs are due to relatively high attentional problems in these groups or due to other factors such as motivation.

Alcoholism↗
PubMed1998

Do young children of alcoholics hold more positive or negative alcohol-related expectancies than controls?

Alcohol-related expectancies and alcohol use were examined in 185 children of alcoholics (COAs) and controls, aged 7 to 18 years. Concerning the expectancies of young COAs, two contrasting hypotheses have been proposed: COAs should hold more negative expectancies than controls due to aversive learning, or hold more positive expectancies due to either social learning or a more favorable response to alcohol. We propose that COAs of elementary school age hold more negative expectancies due to aversive learning, whereas older COAs hold more positive expectancies due to a more favorable response to alcohol. The critical variable with respect to the change from more negative to more positive expectancies is proposed to be the child's own initiation of alcohol use. The results of the present cross-sectional study provide suggestive evidence in favor of this hypothesis. First, elementary school-aged COAs had stronger negative expectancies than controls. Second, the hypothesized interaction between family history and own experience with alcohol was confirmed in the adolescent subsample. The proposed model should be critically tested with longitudinal data. If confirmed, the model may be of importance for prevention of alcohol-related problems in high-risk populations.

Adolescent↗
PubMed1998

Event-related potentials during visual selective attention in children of alcoholics.

Event-related potentials were recorded from 7- to 18-year-old children of alcoholics (COAs, n = 50) and age- and sex-matched control children (n = 50) while they performed a visual selective attention task. The task was to attend selectively to stimuli with a specified color (red or blue) in an attempt to detect the occurrence of target stimuli. COAs manifested a smaller P3b amplitude to attended-target stimuli over the parietal and occipital scalp than did the controls. A more specific analysis indicated that both the attentional relevance and the target properties of the eliciting stimulus determined the observed P3b amplitude differences between COAs and controls. In contrast, no significant group differences were observed in attention-related earlier occurring event-related potential components, referred to as frontal selection positivity, selection negativity, and N2b. These results represent neurophysiological evidence that COAs suffer from deficits at a late (semantic) level of visual selective information processing that are unlikely a consequence of deficits at earlier (sensory) levels of selective processing. The findings support the notion that a reduced visual P3b amplitude in COAs represents a high-level processing dysfunction indicating their increased vulnerability to alcoholism.

Adolescent↗
PubMed1997

No electrocortical evidence of automatic mismatch dysfunction in children of alcoholics.

The mismatch negativity (MMN) event-related potential (ERP) component is an automatic, attention-independent brain response to auditory stimulus change, which has been reported to be smaller in alcoholics relative to nonalcoholic controls. To determine whether MMN decrements might be a trait marker of alcoholism that is also present in nonalcoholic individuals at high risk for developing alcoholism, we investigated MMN in 9- to 18-year-old children of alcoholics (n = 20) and control children (n = 20) in three different stimulus conditions using a passive auditory oddball paradigm. There were no statistically significant between-group differences observed in amplitude, scalp topography, and peak latency of MMN. These findings, if replicated, suggest that reported MMN decrements in alcoholics most likely represent a state marker, and not a trait marker, of alcoholism. Also, inasmuch as another ERP component, the P300, is attention-dependent and reported to be smaller in children of alcoholics, the present results implicate that deviations in attentive, but not in automatic, information processing are associated with alcoholism vulnerability.

Adolescent↗
PubMed1996

Changing a response set in normal development and in ADHD children with and without tics.

The current study was designed to provide a rigorous investigation of the locus of task-inappropriate (impulsive) responding in ADHD children with and without tics. For this purpose we used a variant of Sternberg's (1969) response bias task. The task measures a set of mental operations, namely, preparing a planned response, carrying out or stopping a planned response, and preparing to execute an alternative response. In the first study, we determined the effect of age in a normal sample. As expected, task performance improved as a function of age. Younger children had problems changing a response set. In the second experiment, we compared ADHD children with and without tics with normal children. Unexpectedly, the noticeable task inefficiency of the patient groups was not related to (a) a hasty scan of the display, (b) an inability to change response set, or (c) a speed-accuracy trade-off. Implications for and a discussion about the response inhibition hypothesis in ADHD are discussed.

Attention Deficit Disorder with Hyperactivity↗
PubMed1994

Adenylate cyclase, a biochemical marker of alcoholism?

A possible biochemical vulnerability (trait) marker is examined in a cross-sectional study to determine the biochemical factors associated with the development of alcoholism in a population of non-adult children of alcoholics. The activity of adenylate cyclase, an enzyme that plays a role in the signal transduction pathway of several hormones and neurotransmitters, is assessed in blood platelets. This activity was reported to be lower in blood cells of alcoholics and abstinent alcoholics compared with that in controls. In addition, dysregulation of adenylate cyclase in the CNS of animals seems to be involved in drug-seeking behaviour. The relation between these biochemical findings and psychopathology is currently being investigated in a project by the Amsterdam Institute for Addiction Research.

Adenylyl Cyclases↗
PubMed1994

Children of alcoholics: attention, information processing and event-related brain potentials.

Recent studies on biological markers and risk factors for alcoholism have distinguished between nonalcoholic individuals with a family history of alcoholism and those without such a family history on measures of event-related brain potentials. The main finding of these "high-risk" studies is a smaller amplitude of the P300 component in males with a history of paternal alcoholism. This relationship between P300 amplitude and a family history of paternal alcoholism has been observed in adults and children. Consequently, several authors have suggested that a reduced P300 amplitude could serve as a vulnerability marker for alcoholism. We address several conceptual and methodological issues involved in the study of event-related potentials in children at high risk for alcoholism. Subsequently, the ongoing high-risk study of the Amsterdam Institute for Addiction Research is described briefly.

Adult↗
PubMed1994

Children of alcoholics. Predictors for psychopathology and addiction.

Children of alcoholics have a higher risk of psychopathology and alcoholism. Therefore, in 1993 the Amsterdam Institute for Addiction Research initiated a study on vulnerability markers and risk factors in children of alcoholics, aimed at identifying predictors for the development of psychopathology and addiction in children of alcoholics. This article provides a summary of the background, rationales and aims of the study. With more specific and sensitive biological vulnerability markers that indicate risk status, more effective preventive interventions might become available. The biochemical part of the study aims at answering the question whether adenylate cyclase is a vulnerability marker for alcoholism. The psychophysiological part is directed at event-related potentials during task performance to clarify the nature of the brain and cognitive functions that may underlie or relate to vulnerability to alcoholism. The third part, the psychological component, aims at possible psychological mechanisms of enhanced risk of addition in children of alcoholics as well as the relationship with childhood psychopathology.

Adolescent↗
PubMed1994

Psychological mechanisms of enhanced risk of addiction in children of alcoholics: a dual pathway?

The background and rationale of a recently started project of the Amsterdam Institute for Addiction Research are outlined. This project is aimed at the psychological mechanisms underlying an enhanced risk of (later) addiction in children of alcoholics and the relationship with childhood psychopathology. A dual pathway mechanism is proposed, in which the type of alcoholism of the parent plays a major role. The child of a multigenerational primary alcoholic parent may suffer from an inherited mild dysfunction of the prefrontal cortex, expressed in neuropsychological and personality characteristics similar to those of the alcoholic parent. These are impulsive, aggressive and reward-seeking behaviour, response perseveration and, in some children, related psychopathology such as conduct disorders. For a child of a secondary alcoholic parent, another mechanism is proposed. In these children, stress and social learning may lead to negative affectivity and repressive coping style, with emotional problems at a later age, and the risk of falling into the "circle of secondary alcoholism". In both pathways, alcohol-related expectancies are suggested to constitute a "final common pathway" between different risk factors and later alcohol abuse. Specific expectancies might be related to different pathways and to gender differences in later drinking patterns.

Adaptation, Psychological↗
PubMed1994

Development after prenatal exposure to cocaine, heroin and methadone.

In Amsterdam a longitudinal, prospective and multidisciplinary study on the development of infants of drug-dependent mothers (IDDM) was started in 1983: 35 IDDM and 35 reference infants were originally enrolled. The drug-dependent women had used combinations of methadone, heroin, cocaine and other drugs during pregnancy. Of the IDDM, 80% had to be treated pharmaceutically for neonatal abstinence symptoms (NAS). Physical, neurological, cognitive and the socio-emotional development of the children were studied regularly from birth until 5.5 years of age. Differences between the reference group and the IDDM were found most clearly in cognitive development. The IDDM also had more behavioural problems at some of the ages studied. No group differences were seen in motor development. So far the results of the study show that IDDM and their caregivers need extra support in order to improve early communication and the children's cognitive development.

Case-Control Studies↗
PubMed1989

[Children with autism and related contact disorders: medical aspects].

In children with infantile autism or atypical pervasive developmental disorders somatic aspects play an important role. A review is presented of important hereditary, pre-, peri- and neonatal factors, findings at neurological examination, specific medical disorders and neurochemical and neurophysiological findings. Results of the medical examination of 15 children with autistic or atypical developmental disorders are presented. It is concluded that extensive medical examination of these children is indicated: in 8 out of 15 children a clinically relevant chromosomal, neurological or biochemical disorder could be detected.

Autistic Disorder↗