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Biomedical subjects

W B Klaustermeyer

Publications and source records attributed to W B Klaustermeyer.

At least 37 records · Page 2Linked to original sources
PubMed1990

Enalapril induced angioedema.

A report of three patients who developed angiodema while receiving enalapril. Patient 1 came in with an 8-hour history of facial swelling after enalapril had been started 2 days earlier. The second patient came in with severe angiodema of the tongue, larynx, and glottis requiring emergency tracheostomy, hydroxyzine, and steroids. He had been treated with enalapril for 1 year. The third patient developed facial swelling within a few hours of the first dose of enalapril. Angiodema with enalapril can occur early or late in the course of therapy. A possible mechanism for this drug reaction is the potentiation of bradykinin with resultant kinin system activation.

Aged↗
PubMed1990

Predictive value of monitoring expiratory peak flow rates in hospitalized adult asthma patients.

This prospective single-blind study monitored the progress and outcome of 18 hospitalized asthmatic patients on intravenous corticosteroids by daily peak expiratory flow rate (PEFR) measurements to determine whether daily flow monitoring was useful as a guide for predicting response to therapy over the short- and long-term course posthospitalization. Daily monitoring of PEFR was helpful in demonstrating the response to therapy during hospitalization and at follow-up visit (1 to 2 weeks) posthospitalization. This change in PEFR during acute hospitalization and at initial follow-up visit did not correlate well with relapse or repeat hospitalization during the 5- to 17-month follow-up period.

Adrenal Cortex Hormones↗
PubMed1989

Absence of tachyphylaxis to inhaled atropine in patients with chronic obstructive pulmonary disease.

A multicenter, 14-wk, double-blind, randomized, parallel group study of 60 patients with obstructive lung disease was performed to assess tachyphylaxis with inhaled atropine sulfate versus placebo. Forty patients completed the study; twenty-one were treated with placebo and nineteen were treated with atropine sulfate. Atropine and placebo groups were compared before and after inhaled atropine by spirometry at Weeks zero, 6, and 14. Medication side effects, other medication usage, and symptoms were recorded daily. Comparison of FEV1 response to atropine sulfate from baseline at Weeks zero, 6, and 14 did not show a statistically significant decrease. Inhaled atropine sulfate continued to be an effective bronchodilator in both placebo groups and atropine sulfate groups. There was no evidence of significant tachyphylaxis with atropine. Significant side effects in the atropine group when compared with placebo included dry mouth, dry skin, rapid heart rate, and nausea.

Administration, Inhalation↗
PubMed1989

The laboratory assessment of allergic disease in a veteran population.

In a series of 101 allergy clinic patients, the degree of atopy by clinical history and skin testing was compared with the serum IgE level, total eosinophil count, sinus roentgenograms, and ventilatory function tests. Serum IgE levels were statistically related to the clinical history and skin test evidence for atopy; however, there was a marked overlap in atopic and nonatopic patients. Although sinus roentgenograms were frequently abnormal (50%), the presence or absence of the radiographic sinus abnormality had no relationship to the skin test results, clinical history of allergy, eosinophil count, or serum IgE level. The presence of a sinus roentgenogram abnormality did correlate with the extent of respiratory disease. Similarly, the eosinophil count correlated with the extent of respiratory involvement rather than IgE-mediated hypersensitivity.

Adult↗
PubMed1989

Quantitative immunoglobulins and IgG subclasses in patients with corticosteroid-dependent reversible airway obstruction.

Six of 12 patients with corticosteroid-dependent bronchial asthma and recurrent sinopulmonary infections were found to have significant abnormalities in quantitative immunoglobulins and/or IgG subclasses. Five patients had a combined quantitative immunoglobulin and IgG subclass deficiency and one patient had an isolated IgG deficiency. Combined IgG subclass deficiencies were observed in two patients, both with deficiencies of IgG2 and IgG3. The most common IgG subclass deficiencies were of IgG2 and IgG3, which were found in three patients each.

Adrenal Cortex Hormones↗
PubMed1988

Penicillin anaphylaxis: fatality in elderly patients without a history of penicillin allergy.

Two anaphylactic fatalities following penicillin administration are reported. Neither of the two patients had a history of previous penicillin allergy. Both were elderly and suffered from active cardiovascular disease. Penicillin skin testing may be indicated in some high-risk patients requiring parenteral penicillin, despite a negative history for penicillin allergy.

Aged↗
PubMed1987

Chrysotherapy in the treatment of corticosteroid-dependent asthma.

The efficacy of parenteral gold therapy was evaluated in patients with steroid-dependent asthma. Five of eight patients improved in terms of reduced steroid requirement while they were maintaining or improving lung function. Two patients developed significant proteinuria that resolved with cessation of gold. Chrysotherapy appears to have a corticosteroid-sparing effect in some patients and may have a useful role in the management of severe refractory asthma.

Adrenal Cortex Hormones↗
PubMed1987

Comparison of nifedipine with a new calcium channel blocker, flordipine, in exercise-induced asthma.

Four patients with documented exercise-induced asthma (EIA) were pretreated orally in random, double-blind fashion with the calcium channel blockers nifedipine 20 mg and flordipine 25 and 50 mg and placebo, then subjected to exercise challenge on a cycloergometer. Each patient served as his own control, undergoing exercise challenge with the different pretreatments on 4 separate days. No statistically significant protection from EIA was found with either nifedipine or flordipine.

Adult↗
PubMed1987

Corticosteroid complications in respiratory disease.

Complications observed in 51 patients receiving corticosteroids for greater than 1 year for asthma and other chronic pulmonary diseases were compared retrospectively with 31 control patients who had never been on corticosteroids. The prevalence of Cushingoid features (P less than .005), ocular complications (cataracts and glaucoma, P less than .025), and skeletal complications (compression fractures of vertebrae, aseptic necrosis of the femoral head, and osteopenia, P less than .005) in the study group was significantly higher than in the control group, as was the prevalence of total complications (P less than .005). Multiple regression analysis demonstrated that serious ocular and skeletal complications were directly proportional to the total lifetime dosage of corticosteroids. The high toxicity of steroid therapy should give further impetus to the formulation of ways to reduce or avoid steroid complications.

Adrenal Cortex Hormones↗
PubMed1986

A comparison of intravenous hydrocortisone, methylprednisolone, and dexamethasone in acute bronchial asthma.

The short-term airway response of 14 subjects with severe asthma to equivalent low doses of intravenous hydrocortisone, methylprednisolone, and dexamethasone was examined. Overall the subjects improved without any significant differences between the three groups in subject age, baseline percent predicted FEV1, or percent predicted FEV1 at 3, 6, 9, 24, 48, and 72 hours (P greater than .05).

Adult↗
PubMed1984

The effect of high dose glucocorticoid therapy on immunoglobulin E in asthma.

Serum IgE levels were measured before and after high dose intravenous methylprednisolone therapy in 14 patients with severe asthma. Eight patients received methylprednisolone 125 mg every 6 hours, four received methylprednisolone 60 mg every 6 hours, and two patients received hydrocortisone 100 mg every 6 hours. In patients receiving the higher dose, in extrinsic asthma, and in those not recently receiving corticosteroids, total serum IgE levels tended to decrease within a short interval after corticosteroid therapy.

Adult↗