Herpes zoster in Hodgkin's disease.
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Biomedical subjects
Publications and source records attributed to W B Mill.
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A retrospective analysis of 116 primary cases of stage I, II and III-A Hodgkin's disease demonstrated 27 failures, fourteen confirmed by biopsy. Twenty of the 27 (74%) were in lymph node areas only and seven had extranodal extensions. The most frequent site of failure was the hilar nodes and contiguous lung. The majority of failures (78%) occurred within 30 months of treatment and the cause of failure determined in 23 (85%), sixteen of which were due to technical errors of irradiation. Analysis of the dosimetry in the mediastinal, hilar nodes and contiguous lung failures revealed three factors which may have contributed to a low dose. These factors are: 1) the equivalent square, 2) off-axis beam diminution, and 3) the anteroposterior dose profile. Combined radiation therapy and chemotherapy was more effective than either modality alone in the treatment of these failures.
In this retrospective study of 76 patients with myeloma, the indications for radiation therapy are reviewed and its value analyzed. Eleven patients presented with a "solitary plasmacytoma" and 65 patients presented with disseminated disease. Radiation therapy is successful in both the palliation of pain (81% of cases) and in producing long-term remission and possibly cure in solitary lesions.
A secondary gonadal shield for use in the pelvic irradiation of males was designed and built using material and apparatus available with the Cerrobend blocking system. The gonadal dose was reduced to approximately 1.5 to 2.5% of the given dose.