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Biomedical subjects

W Böke

Publications and source records attributed to W Böke.

At least 37 records · Page 2Linked to original sources
PubMed1982

Bilateral acute retinal necrosis.

Four patients who experienced the sudden onset of anterior uveitis with large keratic precipitates and dense vitreous opacities developed confluent yellow-white swellings and exudates in the peripheral retina and sheathing and obliteration of retinal arteries. After absorption of the exudates, atrophic patches in the peripheral retina and a funnel-shaped retinal detachment with many tears appeared. Angiograms showed retinal edema, fluorescein leakage from the choroid in the affected areas, and perivasculitis of the retinal arteries. Although treatment seemed unable to alter the course of the disease, in one case the retina reattachment after vitrectomy and filling of the vitreous space with silicone oil. Histopathologic studies disclosed extensive atrophy and degeneration of the outer retinal layers and pigment epithelium and occlusion of the retinal vessels. An infection may trigger the uveitis, leading to an autoimmune sensitization against rods and cones that causes severe local immune-complex disease and retinal vasculitis.

Adult↗
PubMed1980

[Experiences with ciliary block ("malignant") glaucoma (author's transl)].

Following a brief review of various interpretations of the disease and its treatment, the author's observations in 13 cases (18 eyes) treated during a period of ten years are reported. The data (Tables 2 and 3) are discussed with reference to the different forms of clinical manifestation of the disease (Table 4). Therapeutic aspects are outlined on the basis of the personal experience of the authors. If conservative measures (mydriasis, hyperosmotics, carboanhydrase inhibitors) fail to control ciliary block glaucoma, surgical procedures directed at the anterior hyaloid membrane are indicated. This structure is approached either via the pars plana or via the transpupillary route after lens extraction. In some cases lens extraction alone was sufficient.

Adult↗
PubMed1980

[Differential diagnosis of postoperative glaucoma following iridectomy and filtering procedures (author's transl)].

The various causes of elevated intraocular pressure following glaucoma surgery are described. One has to differentiate between failures after peripheral iridectomy (Table 1) and those following filtering interventions. The clinical picture of a postoperative narrow-angle glaucoma must be analyzed carefully; it may be due to pupillary block, plateau-iris syndrome or even to a ciliary block (malignant glaucoma). The failure of filtering procedures may be due to mechanisms blocking the trephination opening, cicatrization of the conjunctiva or a ciliary block. The diagnosis criteria of the different conditions and the respective therapeutic measures are outlined.

Diagnosis, Differential↗
PubMed1980

Circulatory disorders of the optic nerve.

Circulatory disorders of the optic nerve may be classified into acute and chronic lesions as well as into anterior and posterior ones. In general, anterior lesions clinically prevail; they are located around the lamina cribrosa and are pathogenetically explained as a consequence of decreased blood flow in the posterior ciliary arteries as well as in the perilaminar capillaries. The symptoms of the acute anterior lesions are described. The nerve head infarction may be induced by various circulatory disorders such as arteriosclerosis, diabetes, elevated blood pressure, giant cell arteritis or other collagen diseases, but also by others. The particular importance of giant cell arteritis is stressed. The prognosis of acute anterior ischemic optic neuropathy is poor, possibilities of treatment are discussed. The chronic anterior lesion is considered to be caused by an imbalance between intraocular pressure and the perfusion pressure in the posterior ciliary arteries and consequently in the perilaminar capillaries. The clinical signs ('low tension glaucoma') are described, the therapeutic measures, although limited, are outlined. The ischemic lesions of the posterior part of the optic nerve are less well defined. However, theoretical considerations as well as clinical experience suggest that such lesions occasionally occur taking either an acute or a chronic course.

Fluorescein Angiography↗
PubMed1979

[Immunopathogenesis of the Vogt-Koyanagi-Harada syndrome].

Regarding immunopathogenesis of the Vogt-Koyanagi-Harada syndrome (VKHS), peripheral blood lymphocytes of a female patient with this disease were tested for sensitization against several antigens such as myelinic basic protein (BP) and uveoretinal, brain and spleen tissue homogenates. For comparison, cells of seven patients with chorioretinitis only and cells of six patients with encephalitis of unknown etiology were also tested. Cells of healthy donors served as controls. The electromobility test and the leucocyte migration test were used as in vitro test systems for cell-mediated immunological reactivity. The results show a strong sensitivity against BP and uveoretinal and brain tissue homogenates in VKHS. In the patients suffering from chorioretinitis, a strong reactivity against uveoretinal homogenate only was found, while in patients with encephalitis, responses to brain antigens only were observed. Reactions towards spleen tissue homogenate were negative in all experiments. The extent to which this tissue-specific immunological reactivity, which is different from the monoreactivity in chorioretinitis or encephalitis, might be a characteristic phenomenon of the VKHS is discussed.

Eye Proteins↗
PubMed1979

[Distribution of 35S labeled sulfated mucopolysaccharides in the recipient eye after corneal allografting. Experimental studies in rabbits].

The release of 35S labeled corneal glycoprotein from an allogenic interlamellar corneal graft was studied in randomly selected rabbits. Simultaneously, the uptake of 35S by the recipient animal was investigated. These changes followed for a period of 80 h indicate that there is a constant 35S release fromthe donor cornea and that it is the recipient cornea which takes up the major part of the 35S from the donor. The iris, choroid, and sclera of the recipient also take up a certain percentage of the donor's 35S while the aqueous humor, the optic nerve, and the local lymph nodes take up only minimal amounts.

Animals↗
PubMed1978

[Choice of technique in rhegmatogenous retinal detachment (author's transl)].

If not complicated by vitreous- or retinal traction the rhegmatogenous retinal detachment has an extraordinarily good chance to be healed surgically. The principle to safely seal the retinal hole by a circumscribed and controlled plombage from the outside of the eye - successfully developed as a surgical method by Custodis - appears now to be accepted everywhere. Nowadays the mayor modifications of this principle are widely used in retinal detachment surgery. The author outlines different clinical pictures patients may present with before surgery. He points to the surgical ways adequate to the given situation. The pros and cons of each approach are discussed. Generally spoken, the author prefers episcleral implants placed whether radially or circumferentially as the case may require. However, other techniques such as intrascleral implants are considered to have also their indications.

Diagnosis, Differential↗
PubMed1978

[Results of the ciliary body exposure (CBE) in secondary angle closure glaucomas. 1. A clinical study (author's transl)].

The authors present their clinical results of the ciliary body exposure following Benedikt and Hiti. This technique has been performed in 23 patients suffering from secondary angle closure glaucoma. As far as the intraocular tension is concerned good results have been obtained in nearly half of the patients. The results are compared with those of other surgical techniques against secondary angle closure glaucomas.

Aged↗
PubMed1978

[Results of the ciliary body exposure (CBE) in secondary angle closure glaucomas. 2. A histological study (author's transl)].

After treatment of secondary angle closure glaucomas by ciliary body exposure with lamellar scleral resection five eyes had to be enucleated. In view of the histological findings taken from these eyes mode of action and therapeutic value of this operation are considered. The effectiveness of scleral resection seems to be doubtful and there is evidence that permanent regulation of intraocular tension depends mainly on direct diathermy of the ciliary body.

Ciliary Body↗