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Biomedical subjects

W Bacon

Publications and source records attributed to W Bacon.

At least 19 recordsLinked to original sources
PubMed1992

The cranial base in subjects with dental and skeletal Class II.

The aim of this study was to test to what extent the cranial base variations may be involved in Class II facial organization. Using Bonferonni probabilities, cranial base size and shape, and facial divergence were compared in two groups: an experimental group of 45 subjects with dental and skeletal Class II and an homologous control group of 41 subjects with a natural Class I ideal occlusion. In all individuals of the experimental group the Class II molar relationship was at least equal to the width of one premolar and the ANB angle was greater than the value of the mean +2 standard deviations of the ANB in the control group. Spacing and crowding was less than 2 mm at each arch in both groups; all subjects were between 10 and 12 years old. The anterior part of the cranial base (SN length and SNBa angle) was identical in the two groups, but in Class II, cranial base flexure (BaSN angle) was more obtuse (P less than 0.05) and posterior cranial base angle (SBaN) was more acute (P less than 0.01). These variations co-existed in the same group with a more retruded position of the condylar neck in the face (P less than 0.01) favouring per se a post-normal relationship of the mandible to the maxilla. The increased extension of the saddle angle in Class II could not be considered here as related to an hyperdivergent facial pattern since facial divergence was unchanged in Class II. Saddle angle and divergence correlated in Class I (r = 0.40; P less than 0.01), but not in Class II.(ABSTRACT TRUNCATED AT 250 WORDS)

Cephalometry↗
PubMed1992

[Pharyngeal obstruction and the functional adaptation of the natural posture of the head and the hyoid bone in sleep apnea syndrome].

Variations in natural head posture (NHP) and hyoid bone (HB) positioning impart changes in the size and shape of the pharyngeal airways. In SAS, which was shown to be correlated with detrimental craniofacial anatomical conditions, control of pharyngeal permeability is lost during sleep. The aim of this study was determine if functional adaptation of NHP and HB position to these detrimental conditions could be observed, using Bonferonni probabilities, in a cephalometric comparison of 38 SAS adults in the wakeful state and a control group of 38 healthy adults. Since HB relationships with craniofacial anatomical structures vary with the positioning of the head, the cephalograms were taken according to the preliminarily tested NHP, thus making the method reproducible. In SAS craniovertical angulation was unchanged, but the head was maintained in a forward position (increased cervico-vertical angulation, P < 0.001). Maintenance of an acceptable pharyngeal permeability was associated with a more distant positioning of HB from the cervical column (P < 0.01) and from craniofacial references (P < 0.001). In spite of these facts lower pharynx opening was still reduced (P < 0.05). Soft palate and facial divergence were expectedly increased in the apneic group. All the individuals but one control could be correctly reclassified with the help of soft palate length, facial divergence, and two HB related variables. Prevention of pharyngeal collapsibility in SAS seems to be commonly associated with functional adaptation of NHP and HP position. The precise control mechanisms of this adaptation remains to be elucidated. Skeletal predispositions to SAS do probably develop already during infancy.

Adaptation, Physiological↗
PubMed1990

Fat embolism syndrome complicating intraarterial chemotherapy with cis-platinum.

A 19-year-old man with telangiectatic osteosarcoma of the left proximal femur was started on a course of neoadjuvant chemotherapy consisting of intraarterial administration of cis-platinum. Within 72 hours of receiving the first intraarterial dose, the patient developed signs and symptoms of fat embolism syndrome (FES). A physical examination revealed cyanosis, tachycardia, and seizure activity. Laboratory studies demonstrated a pO2 of less than 65 mmHg, lipuria, and a drop in hematocrit of three percentage points. There was no clinical or roentgenographic evidence of pathologic fracture. Tumor necrosis secondary to intraarterial cis-platinum therapy in this patient with osteosarcoma may have caused a sudden release of free fatty acids and embolization of fat macroglobules that precipitated this episode of FES. FES in association with the intraarterial administration of cis-platinum seems not to have been previously reported.

Adult↗
PubMed1989

[Vertical typology and natural posture of the head].

The relationship between head posture and vertical typology were evaluated in a sample of 98 young adults. Sub groups of opposite typology were also compared. A strong correlation existed between head posture and facial divergence when evaluated with the variable SN/PM and face post./face ant. Head posture is in extension when facial divergence is important. No correlation existed between posture and % face inf. Face post./face ant. was the best variable in evaluating the relationship between vertical typology and head posture.

Adult↗
PubMed1989

[The question of root resorption. Is the risk of root resorption related to the typology of the face?].

The mechanisms involved in root resorption are of the same nature than those leading to bone resorption. The state of calcification and the local conditions in the microenvironment are responsible for the different responses of alveolar bone and root with regard to calcified matrix resorption. Root resorption is commonly observed in association with impacted cuspids, acute chronical trauma, inflammatory or idiopathic conditions. Root resorption is more frequent in females and is independent on facial typology or orthodontic technique. Critical conditions to root integrity are often associated with heavy forces and periodontal ligament disruption. Root anatomy may also be a predisposing factor to resorption. Systematic radiological examination is the only way to control the onset of a root resorption process in orthodontic therapy.

Cephalometry↗
PubMed1989

[Bone resorption in orthodontic tooth movement: an attempted schematization].

The osteoclast is the major cellular agent of bone resorption. Hormonal stimulation of bone resorption is indirect and depends on the osteoblastic function. Protease production is the final common pathway through which osteoblastic cells initiate osteoclastic resorption. Exposition of the mineralised matrix and contact with the osteoclasts always comes before resorption, regardless of the stimulating agent involved in the resorption process. In orthodontic conditions, production and activation of osteoclasts may be attained through different ways. Inflammation subsequent to tissue damage and bioelectric perturbations associated to alveolar bending can be considered as two major events which may lead to increase bone resorption and orthodontic tooth displacement. The precise transduction mechanism of an orthodontic force into cellular resorbing activity is still obscure.

Alveolar Process↗
PubMed1987

The treatment of bulimia nervosa.

We review treatment approaches to bulimia nervosa, with particular emphasis on methodology and research design. The following treatments are considered: behaviour therapy, cognitive behaviour therapy, pharmacological treatment, group therapy, psychoanalytic psychotherapy, self-help and support groups, hypnosis and miscellaneous (family therapy and nutritional approaches). Several directions for future research and methodological recommendations are suggested.

Anticonvulsants↗
PubMed1985

Developmental expression of a synaptic vesicle-specific protein in the rat retina.

In order to examine the appearance of synaptic vesicles and to correlate it with the formation of the synaptic layers, we have determined the staining pattern of a murine monoclonal antibody (SV 48) to a synaptic vesicle-associated protein in developing rat retina. The antigen was detected by the indirect immunofluorescence technique using cryostat sections of paraformaldehyde-fixed retinas. In the adult retina, the antibody stained both the outer plexiform (OPL) and the inner plexiform layers (IPL). The nuclear layers and the nerve fiber layer (NFL) were devoid of any staining. In prenatal and early postnatal (P) retinas, the antibody stained two bands which corresponded to the respective locations of the NFL and IPL. Staining in the NFL increased until P-4 and began to decline subsequently, and by P-8 little staining was left in this layer. In contrast, in the IPL, the intensity of staining increased gradually and leveled off by P-10. In the outer retina, a band of fluorescence corresponding to the OPL was first observed at P-5 and increased in intensity up to P-10. Immunoblotting studies showed that the major immunoreactive material from adult and embryonic retinas had a Mr approximately 65,000-67,000. As expected from its developmental pattern, all bands appeared initially in the central retina and subsequently in the peripheral retina. Our results show that the synaptic vesicle-protein is present in the nerve fiber layer before synaptogenesis in the central nervous system. Subsequently, the protein is lost from the NFL, possibly as a consequence of synapse formation.

Animals↗