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Biomedical subjects

W Behrendt

Publications and source records attributed to W Behrendt.

54 records · Page 3Linked to original sources
PubMed1983

[Mr 1268--a new furylmethyl-substituted benzomorphan. Comparison of its effects with pentazocine and placebo in a double-blind study].

Mr 1268 (alpha-5,9-dimethyl-2(3-methyl-3-methylfuryl)-2-hydroxy-6, 7-benzomorphan) was tested in two dosages (15 mg and 30 mg) at random on a total of 200 patients with severe postoperative pain in a double blind study against pentazocine and placebo. The analgesic effect of 30 mg Mr 1268 and 30 mg pentazocine compared with placebo was statistically significant 15 min after intramuscular injection. At the dosage applied no major respiratory or circulatory effects were observed in the patients. The minimal changes in the systolic blood pressure were of no statistical significance. Side-effects observed in many patients in the verum group were miosis and transpiration. For all other side-effects there was no statistically significant difference between placebo and the verum group or among the various verum groups.

Adult↗
PubMed1983

[Reduced parenteral calorie administration after severe multiple injuries].

15 polytraumatized patients were treated within 5 posttraumatic days with reduced calorie and normal amino-acid supply (17 kcal/kg BW as carbohydrates and 1.0 g AA/kg BW). Changes in carbohydrate and protein metabolism were investigated. The fluid volume for parenteral nutrition did not exceed 2,000 ml/day. In spite of restricted carbohydrate dosage, we still needed 28IU of insulin daily to keep the blood glucose within a range of 8-10 mmol/l. Nitrogen balance ranged between -7 and -12 g per day. The unstable serum proteins transferrin, prealbumin, retinol-binding protein and the cholinesterases remained within normal values. Plasma AA showed the familiar pattern of the posttraumatic state with elevated levels of nearly all AA including BCAA although we were using a solution with a reduced BCAA content. The free fatty acids in serum reached values 40% above normal, the triglycerides remained within normal values. Infusion therapy can be considerably simplified by reducing carbohydrate dosage. The risk of intensifying existing metabolic disturbances declines. After five posttraumatic days a combined parenteral/enteral nutrition offering more calories was possible in 70% of our patients.

Adolescent↗
PubMed1982

[Plasma amino acids in gynecologic operations].

Complete solutions with amino-acids, carbohydrates and electrolytes are able to reduce the metabolic changes of so-called postaggression-metabolism (adaptation-disease). The infusions can be used routinely for basic-partial parenteral nutrition from the end of operation treatment to beginning of oral nutrition. It is not necessary to control many parameters. Realising this practice postaggression-metabolism in gynecologic patients will be normalised soon.

Amino Acids↗
PubMed1982

[Urea and potassium losses and changes in amino acid concentration after aortocoronary bypass operations].

Changes in urea nitrogen excretion, renal potassium losses, and changes of amino acid concentrations in plasma following aortocoronary bypass operations were observed in 10 patients. The observation time included the preoperative day, the day of operation, and 4 postoperative days. The patients were treated with a 5% glucose solution (800-1000 ml/m2). The additional spontaneous oral intake was estimated and reached approximately 600-800 kcal and 25-30 g protein on the 3rd and 4th postoperative day. The calculated urea nitrogen loss was between -8.2 g (operation day) and -11.2 g (4th postoperative day). The concentrations of serum amino acids in plasma were below normal preoperatively. It seems possible that this is due to longer preoperative fasting because only patients with normal body weight were admitted to operation. The amino acid concentrations fell significantly to lower than normal values during the postoperative period. There were massive renal losses of potassium of about 140 mEq/day on the day of operation and on the 1st postoperative day. High parenteral substitution was necessary to avoid severe falls in serum potassium levels and possible cardiac arrythmias.

Amino Acids↗
PubMed1982

[Metabolic changes following aorto-coronary bypass operations (author's transl)].

Metabolic changes following aorto-coronary bypass operations were observed in 10 patients. The observation time included the preoperative day, the day of operation, and 4 postoperative days. The patients were treated with a 5% dextrose solution for a period of 2 or 3 days. Additional oral feeding beginning on the 2nd or 3rd postoperative day was possible. This spontaneous calorie and nitrogen intake was estimated. There was an urea-nitrogen loss of 6.9 +/- 3.2 g (S.D.) on the day of operation and of 13.5 +/- 6.3 g (S.D.) the 4th postoperative day. From these values the nitrogen balance was calculated to be -8 g (operation day) and -11 g (4th p.o. day). Concentrations of the plasma pseudocholinesterases, the prealbumin, and the retinolbinding protein fell significantly to lower than normal values. Glucose utilisation was severely depressed on the day of operation. There were massive losses of potassium of about 140 +/- 41 mmol (S.D.) on the day of operation and the 1st postoperative day. Serum zinc levels were significantly below normal for 2 postoperative days combined with a high urinary excretion. The increase of free fatty acids in serum postoperatively was within normal values.

Aged↗
PubMed1981

[Standardized postoperative parenteral nutrition with a complete solution containing glucose].

15 cholecystectomized patients were treated with a newly developed solution containing 2% amino acids, 12.5% dextrose, and electrolytes during a period of 3 postoperative days. The solution with an osmolarity of 1.060 mosmol/l was administered by peripheral veins. Blood glucose concentration did not exceed 8.8 +/- 1.3 (S.D.). Application of insulin or additional potassium was not necessary. Glucose excretion ranged from 3.3 to 7.6 percent of the infused dose. Urinary nitrogen excretion was approximately 8.4 +/- 2.2 (S.D.) g/day. From this the nitrogen balance was calculated as -2.6 g/day. There were no systemic side effects of the solution; in some cases an irritation of peripheral veins was observed.

Amino Acids↗
PubMed1977

[Pulse cytophotometric investigations concerning the biological behaviour of laryngeal carcinomas (author's transl)].

25 laryngeal carcinomas were investigated by pules cytophotometry, stained with ethidium bromide after pepsination. The karyograms were interpreted as DNA-distribution curves. In diploid populations the height of the 4c-peak was taken as a measure of proliferation rate. Aneuploidy and polyploidy were estimated by camparison with human diploid material . In our material we found 13 polyploid tumors (under them 6 aneuploid populations from 7 at all). After dividing the cases into two groups (1: with slow, 2: with rapid progression) the moiety of polyploid and aneuploid tumors and the height of the 4c-peak was significantly higher in group 2. The pulse cytophotometry gives reliable additional informations showing the great variability of biological characteristics of laryngeal carcinomas. Possibly this is a basis of a more differentiated therapy.

Aneuploidy↗