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W Bennett

Publications and source records attributed to W Bennett.

54 records · Page 3Linked to original sources
PubMed1985

Gallium-67 scintigraphy in well-differentiated lymphocytic lymphoma of the skin.

Skin lymphomas are now divided into "T" or thymic cell lymphomas (mycosis fungoides being the principal type) and "B" cell lymphomas after the bursa of Fabricius. The "T" cell lymphomas all are identified by the thymic or cerebriform cell. Those lymphomas of the skin which do not contain these characteristic cells are derived from the bursa cells and are termed "B" cell lymphomas. A large percentage of these non "T" cell lymphomas have been histologically diagnosed as lymphocytic lymphoma of the skin (1). The authors had an opportunity to scan a patient with histologically proven lymphocytic lymphoma of the skin with Ga-67 and obtained on excellent correlation between gallium accumulation in the skin lesions and histologic confirmation of lymphocytic lymphoma.

Gallium Radioisotopes↗
PubMed1983

The nicotine fix.

Explore the source record for details and available documents.

Adolescent↗
PubMed1979

Synaptic phosphoproteins: specific changes after repetitive stimulation of the hippocampal slice.

Repetitive stimulation (100 pulses per second for 1 second) of the Schafer collateral-commissural system of the rat hippocampus induces long-term potentiation of synaptic strength and produces significant changes in the subsequent endogenous phosphorylation of a 40,000-dalton protein from synaptic plasma membranes. This effect is not observed after stimulation in calcium-deficient media or after simulation at the rate of one pulse per second for 100 seconds. These findings provide evidence that repetitive synaptic activation can alter the phosphorylation machinery of the synaptic region and suggest a biochemical process which may be involved in the production of neuronal plasticity.

Animals↗
PubMed1976

Effects of ouabain on myocardial oxygen supply and demand in patients with chronic coronary artery disease. A hemodynamic, volumetric, and metabolic study in patients without heart failure.

The effects of digitalis glycosides on myocardial oxygen supply and demand are of particular interest in the presence of obstructive coronary artery disease, but have not been measured previously in man. We assessed the effects of ouabain (0.015 mg/kg body weight) on hemodynamic, volumetric, and metabolic parameters in 11 patients with severe chronic coronary artery disease without clinical congestive heart failure. Because the protocol was long and involved interventions which might affect the determinations, we also studied in nine patients using an identical protocol except that ouabain administration was omitted. Left ventricular end-diastolic pressure and left ventricular end-diastolic volume fell in each patient given ouabain, even though they were initially elevated in only two patients. Left ventricular end-diastolic pressure fell from 11.5+/-1.4 (mean+/-SE) to 5.6+/-0.9 mm Hg (P less than 0.001) and left ventricular end-diastolic volume fell from 100+/-17 to 82+/-12 ml/m2 (P less than 0.01) 1 h after ouabain infusion was completed. The maximum velocity of contractile element shortening increased from 1.68+/-0.11 ml/s to 2.18+/-0.21 muscle-lengths/s (P less than 0.05) and is consistent with an increase in contractility. No significant change in these parameters occurred in the control patients. No significant change in myocardial oxygen consumption occurred after ouabain administration but this may be related to a greater decrease in mean arterial pressure in the ouabain patients than in the control patients. We conclude that in patients with chronic coronary artery disease who are not in clinical congestive heart failure left ventricular end-diastolic volume falls after ouabain administration even when it is initially normal. Though this fall would be associated with a decrease in wall tension, and, therefore, of myocardial oxygen consumption, it may not be of sufficient magnitude to prevent a net increase in myocardial oxygen consumption. Nevertheless, compensatory mechanisms prevent a deterioration of resting myocardial metabolism.

Adult↗
PubMed1976

A light and electron microscopic analysis of gentamicin nephrotoxicity in rats.

The sequence of proximal tubular damage and repair after gentamicin sulfate administration was studied by light and electron microscopy in Fischer 344 rats. The drug was administered at a dose of 40 mg/kg for up to 14 days. Although epithelial destruction was progressive with time, the extent and degree of tubular damage varied among animals at each interval. Tubule regeneration began to occur by the tenth day despite continued drug administration. Regenerating cells appeared to originate from residual epithelial cells in areas of tubular damage. The morphologically immature regenerating cells are apparently metabolically immature as well and appear not to be susceptible to toxic effects of the drug. Tubules were repopulated by 3 days following cessation of gentamicin administration. Except for foci of tubular atrophy and interstitial fibrosis, cortical tissues were comparable to controls ultrastructurally at the end of 31 days.

Acute Kidney Injury↗
PubMed1976

Extrarenal manifestations of cystic kidney disease.

Cystic disorders of the kidney may manifest their presence not only through renal but also through systemic signs and symptoms. Extrarenal manifestations include cerebral aneurysms, hepatic cysts, hepatic fibrosis, polycythemia, and retinal changes. Awareness of such associations strengthens the likelihood that renal cystic disease will be detected in its earlier stages. Involvement of organs other than the kidneys takes on added significance as the lives of affected individuals are prolonged through dialysis and renal transplantation.

Adolescent↗
PubMedDate not supplied

Angiosarcoma of the carotid artery: a case report.

Angiosarcomas are rare tumors, particularly in the head and neck region. A case report of an angiosarcoma arising in the internal carotid artery is described; such an occurrence has not previously been reported. The etiology, pathology, and treatment of this unusual tumor are discussed.

Carotid Artery Diseases↗
PubMedDate not supplied

AIDS: has the problem been adequately assessed?

Epidemiologic inferences about the epidemic of acquired immunodeficiency syndrome (AIDS) are developed from three different sources: case-control studies, cohort studies, and national data on prevalence and incidence. Together these data imply that reducing the number of sexual partners may in itself provide little protection. Shifting to a "lower-risk" behavior will only be helpful if the cumulative risk of transmitting the virus can be reduced nearly to zero. However, if all members of a minimally affected population made such a shift, the benefit to that population could be dramatic. The emerging realization that latency periods are longer than was first thought implies that the epidemic could be much more severe than has been anticipated. Regional trends give no assurance that it has reached a peak, even in areas of highest prevalence. Much more work needs to be done to establish the actual role of saliva in transmitting HTLV-III because oral contagion has the greatest potential to spread the disease. Efforts to determine the latency period are crucial to predicting the future of the epidemic. Preventive measures--behavior modification and education--hold some hope of retarding spread of the epidemic pending development of effective therapy or a vaccine.

Acquired Immunodeficiency Syndrome↗