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Biomedical subjects

W Bessler

Publications and source records attributed to W Bessler.

At least 55 records · Page 3Linked to original sources
PubMed1977

[Radio-isotope investigations in bone and joint disease (author's transl)].

Scintigraphy of the skeleton has a definite place. It is indispensable in examinations of clinically or radiologically doubtful lesions and should be routinely used for the classification of malignant tumors. Scintigrams may often provide additional information to radiographs and make possible more precise diagnosis or assessment of results of treatment.

Adult↗
PubMed1975

[Skeletal scintigraphy. Its diagnostic possibilities and indications as compared to x-ray studies].

The properties of bone-seeking nucleids in current use are reviewed and the diagnostic potentialities of skeletal scintigraphy discussed. Osseous lesions are recognized earlier on bone scans than on roentgenograms. They are more precisely delimited and the possibility of healing can be evaluated. Roentgenographic bone survey should be replaced by whole body scans, but since a positive scintigraphic finding may be caused by different osseous processes, a specific roentgenographic check is necessary. The indication for bone scanning has been widened and depends on the clinical situation or on previous X-ray findings.

Adolescent↗
PubMed1975

Escherichia coli capsule bacteriophages. IV. Free capsule depolymerase 29.

The free host capsule depolymerase, induced by Escherichia coli capsule bacteriophage no. 29, and causing the formation of haloes around its plaques, has been purified to homogeneity. As judged from the following facts, this "enzyme" consists of free phage 29 spikes. (i) Detached phage organelles and depolymerase 29 particles exhibit the same molecular weight (about 245,000, as determined from the sedimentation equilibrium), contain polypeptide chains of the same two sizes (57,000 plus or minus 3,000 and 29,500 plus or minus 2,000, as determined by SDS-PAA gel electrophoresis), and have (within experimental error) the same sedimentation coefficient, isoelectric point, and amino acid composition. (ii) Isolated depolymerase and phage spikes in situ both catalyze the hydrolysis of glucosidic bonds in host capsular polysaccharide, leading ultimately to the formation of oligosaccharide fragments of one, two, and three hexasaccharide repeating units. (iii) Depolymerase 29 and phage 29 spikes have roughly the same electron optical dimensions. As tentatively estimated from the total and the virus-associated capsule depolymerase activity in the lysates, phage 29 infection seems to produce eight to seventeen times more free than incorporated spikes.

Amino Acids↗
PubMed1974

Stimulation of mitogenesis in normal and leukemic human lymphocytes by divalent and tetravalent lima bean lectins.

Two hemagglutinating components purified from the lima bean and composed of identical 62,000-molecular-weight subunits have mitogenic activity in normal and leukemic human lymphocyte cultures. Component II (247,000 molecular weight), a tetramer with four saccharide binding sites, is severalfold more active than component III (124,000 molecular weight), a dimer with two binding sites per molecule, as a mitogen for normal lymphocytes. Component II also stimulates mitogenesis in populations of cultured leukemic lymphocytes and appears to have greater activity than phytohemagglutinin-P in leukemic lymphocyte cultures obtained from some patients. Lima bean component III has minimal mitogenic activity toward leukemic lymphocytes. Components II and III appear to compete for the same cell-surface binding sites, but component II has a much greater capacity than component III to trigger DNA synthesis at low concentrations (2.5-25 mug/ml) in normal lymphocyte cultures. These results suggest that the mitogenic activity of lima bean lectin components is directly related to their valence.

Cells, Cultured↗