PubMed Health⌕ Search

Biomedical subjects

W Bischof

Publications and source records attributed to W Bischof.

59 records · Page 4Linked to original sources
PubMedDate not supplied

Immunohistochemical study on the initiation of acid phosphatase secretion in the human prostate. Cytochemistry and biochemistry of acid phosphatases IV.

Acid phosphatase was purified from human prostatic tissue and from seminal plasma. Antisera to antigens from both sources were raised in rabbits. These antisera have been used for immunohistochemical localization of the respective antigens in the prostates of neonatal, infantile, prepubertal, and adult individuals. Immunoreactivity of the prostatic epithelium with the seminal fluid-derived antigen developed progressively in pubertal specimens with increasing age. It was not present in fetal and infantile organs. Antiserum prepared from human prostatic tissue-derived acid phosphatase gave a positive immunoreaction both with stroma and epithelium of the pre- and postpubertal glands. The results give evidence for a clear cut androgen-dependence in the appearance of the acid phosphatase present in semen, which therefore has been identified as secretory. The second antigen is nonsecretory, tissue-bound, nonandrogen dependent, and shares antigenic determinants with leukocyte-derived acid phosphatase.

Acid Phosphatase↗
PubMedDate not supplied

Carcinoembryonic antigen-like substance is a marker of prostatic secretory function.

Specimens of pre- and postpubertal and adult prostatic tissue and seminal vesicles were examined for the presence of carcinoembryonic antigen-like immunoreactivity. A positive immunoreaction of the epithelium of the prostate was observed after the onset of puberty and was comparable to that of secretory acid phosphatase. It was absent from the epithelium of the seminal vesicles. The CEA-like substance of the prostate may therefore be used as a marker of prostatic secretory activity.

Acid Phosphatase↗