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Biomedical subjects

W Borkowski

Publications and source records attributed to W Borkowski.

11 recordsLinked to original sources
PubMed1978

Pyrimethamine in prevention of relapses of meningeal leukemia: report of two cases.

Relapses of meningeal leukemia occurred in two children during hematologic remission of acute lymphoblastic leukemia. Treatment of CNS leukemia consisted of radiotherapy and repeated intrathecal injections of methotrexate and cytosine arabinoside. Intrathecal installations of the drugs were accompanied with increasing neurological side effects which seemed to be lifethreatening. To avoid them, repeated courses of pyrimethamine were introduced. No further relapse of meningeal leukemia occurred after pyrimethamine. Hematologic remissions in both children have lasted for over 7 years. All therapy was stopped 16 months ago.

Central Nervous System↗
PubMed1978

MVPP chemotherapy combined with radiotherapy in the treatment of Hodgkin's disease in children.

Thirty-four children with Hodgkin's disease were treated during the years 1969--75. After radiotherapy, 7--15 cycles of MVPP were given within 24--53 months. In order to avoid chronic leukopenia, leukocyte counts were made frequently during chemotherapy, and the drug doses adjusted accordingly. A complete remission was obtained in 32 of the 34 children. Two patients died because of progressive disease. Twelve of the 32 survivors have been followed for at least 5 years, and a further 12 for at least 3 years. Three children are still on chemotherapy, whereas the remaining 29 being followed are in continued complete remission.

Adolescent↗
PubMed1975

Neutrophil alkaline phosphatase activity in the early puerperium.

Neutrophil alkaline phosphatase studied cytochemically according to Kaplow's method in 20 healthy women aged 20 to 38 years, shows statistically significant, although transient, increase on the second day after physiological delivery and returns to initial values after several days. The above increase is unrelated to the increased enzyme activity observed in the terminal months of pregnancy in a majority of healthy women. It is associated with an increase in neutrophilic granulocytosis in the puerperial period.

Adult↗