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W Bornschein

Publications and source records attributed to W Bornschein.

25 records · Page 2Linked to original sources
PubMed1976

[Comparison between a titrimetric and a photometric method for determination of serum lipase activity (author's transl)].

Comparative studies of two methods for the determination of serum lipase activity (SLA) in human serum show in both methods, the one titrimetric the other photometric, a comparable sensivity and comparable results, especially within the group of subjects suffering from pancreactic diseases. The values of SLA within the group of 45 patients with acute and chronic pancreatic diseases and within a control group of 39 persons without pancreatic affections show a marked correlation for each group. The values of SLA obtained with the titrimetric method of Rick are found to be higher, which would be due to better conditions of the procedure. Also in the study of precision the titrimetric method gave a better result. The determination of SLA with both methods includes post-heparin-lipase-activity (PHLA).

Acute Disease↗
PubMed1975

[Isoenzymes of alanine arylamidase (AAP, EC 3.4.11.2) and gamma-glutamyltranspeptidase (GGTP, EC 2.3.2.2) in chronic pancreatitis and pancreas neoplasm (author's transl)].

In 22 patients with chronic pancreatitis and 16 patients with pancreas neoplasms gamma-glutamyltranspeptidase (GGTP) and alanine arylamidase (AAP) in serum were measured and the isoenzymes were determined by gel electrophoresis on Agar. No specific isoenzyme pattern was found for chronic pancreatic diseases in a comparative investigation with a group of 19 patients suffering from hepatobiliary diseases. Two fractions of AAP and GGTP isoenzymes were found on agar gel electrophoresis: alpha-1 and alpha-2 (GGTP between alpha-2 and beta-globulin). The alpha-1 fraction of AAP and GGTP seems to be a specific liver isoenzyme. The slower fraction of both enzymes was also found in chronic pancreatic diseases and cholestatic diseases as in neoplasms of liver, pancreas and biliary tract. Practical importance of the findings is diminished by large variation coefficients of the results. A significantly low ratio of alpha-1 to alpha-2 fraction (or beta-globulin) on electrophoresis of the isoenzymes of AAP and GGTP was found in the group with neoplasm of pancreas (especially neoplasm of the pancreas head) as compared to the group with intrahepatic cholestasis. The possible causes and diagnostic importance of the findings are discussed.

Alanine↗
PubMed1975

[Isoenzymes of alaninarylamidase and gamma-glutamyl-transpeptidase in intrahepatic and extra-hepatic cholostasis (author's transl)].

In 43 patients with intrahepatic and extrahepatic cholostasis alaninarylamidase (AAP) and gamma-glutamyl-transpeptidase (GGTP) in serum were measured and the isoenzymes were determined in agar-gelectrophoresis. The isoenzyme-fraction 2 (in alpha-2-globulin running) of AAP was significant higher in the group of extra-hepatic cholostasis than in the group of intrahepatic cholostasis. Practical importance of the findings is diminished by large variation coefficients of the results. The importance of isoenzymes of GGTP for differentiation of cholostasis is not large. A special low quotient of two anodic isoenzymes of GGTP (fraction running with alpha-1-globulin to fraction running with beta-globulin) indicates probably a neoplasm of pancreatobiliary tract if there is a high level of total serum-GGTP.

Alanine↗
PubMed1975

[Serum lipase activity and endoscopic retrograde pancreatography in chronic pancreatitis and pancreatic neoplasm (author's transl)].

Serum lipase activity was measured in 360 patients with the clinical suspicion of chronic pancreatic disease, 60 of them also having the lipase evocation test (serum lipase activity before and after pancreatic stimulation with secretin and pancreozymin). Of 48 with chronic pancreatitis (40 confirmed at operation) the diagnosis was made by endoscopic retrograde pancretography in all but one. Serum lipase activity was abnormal in 38. Without those cases associated with pancreatic insufficency, serum lipase activity-spontaneously and after the evocation test-was abnormal in 46 patients. Nine of 10 patients with papillary stenosis had the diagnosis confirmed at surgery, the pancretographic findings co-inciding with the surgical ones in all instances. All the five patients with abnormally high serum lipase activity also had chronic pancreatitis on pancreatography. In all of the 18 patients with pancreatic neoplasm pancreatography gave the same results as operation or post-mortem findings. In eight of these serum lipase activity was spontaneously elevated. The lipase evocation test was shown to be most effective if 2 C.H.R.- U/KG-h each of pancreozymin and secretin were administered. Serum lipase results were falsely positive in 17 of 300 patients with clinical suspicion of pancreatic disease but normal pancreatographic findings.

Adult↗
PubMedDate not supplied

The role of Campylobacter (Helicobacter) pylori in disorders of the gastrointestinal tract.

To evaluate the role of Campylobacter pylori in different gastrointestinal disorders, serum IgG antibodies against C. pylori were determined in dyspeptic patients and in a control group of healthy children and adults. Twenty-eight percent of the dyspeptic patients with normal mucosa were seropositive. Among the patients with altered mucosa, the seroprevalence increased from duodenitis (48%) to gastritis (89%) and gastric or duodenal ulcer, gastric stump gastritis and carcinoma (100%, for each group, respectively). The C. pylori detection rate was lowest in patients with duodenitis alone (19%) and highest in patients with duodenal ulcers (95%). Therefore, C. pylori does not play an important role in patients with duodenitis alone. About 30% of patients with gastritis, active duodenal or gastric ulcer had antibody levels as low as the seroconverted dyspeptic patients but with normal gastroduodenal mucosa. C. pylori was not considered a causative factor for mucosal damage in these patients.

Adolescent↗