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Biomedical subjects

W Botnick

Publications and source records attributed to W Botnick.

3 recordsLinked to original sources

The NCCN Guidelines Development Program.

The National Comprehensive Cancer Network (NCCN) has begun a program for the development of comprehensive clinical practice guidelines for the management of the most common tumors. The NCCN guidelines reflect a process of consensus that relies on evaluation of the evidence and structured feedback. The guidelines are designed to reflect clinical decision-making, and attempt to deal with the complexity of managing cancer. The initial guidelines effort has yielded eight guidelines for adult cancers and three for pediatric cancers. The guidelines are set up in algorithm format. The NCCN members believe that clinical trials are always an appropriate form of patient management, and that the inclusion of a patient in a clinical trial is preferred at every decision point in the algorithm.

Clinical Trials as Topic↗

Evaluation of preliminary NCCN guidelines by external review.

The National Comprehensive Cancer Network (NCCN) guidelines development process is based on a system of iterative review. In addition to review of the preliminary guidelines by member institutions, we surveyed attendees at the NCCN's First Annual Conference about the appropriateness of the guidelines recommendations. After each presentation session, a broad range of health-care professionals, including non-NCCN academic and community oncologists and corporate and third-party representatives, completed a survey instrument. In this article, we summarize and comment on the results of these surveys.

Humans↗

Endobronchial urokinase for dissolution of massive clot following transbronchial biopsy.

Endobronchial streptokinase has been used previously to dissolve blood clots caused by massive spontaneous hemoptysis, in settings including sarcoidosis, cavitary histoplasmosis, and multiple myeloma. To our knowledge, however, the use of thrombolytic agents to dissolve clots following transbronchial biopsy has not been reported previously. We describe a patient in whom endobronchial urokinase was used for successful dissolution of clots secondary to massive bleeding after transbronchial biopsy.

Biopsy↗