Biomedical subjects

W Bowman

Publications and source records attributed to W Bowman.

4 recordsLinked to original sources

PubMed1986

Mode of action of the antimicrobial compound 5-bromo-5-nitro-1,3-dioxane (bronidox).

The mode of action of the antimicrobial agent, 5-bromo-5-nitro-1,3-dioxane (bronidox), was studied in detail for gram-positive and gram-negative bacteria, yeast and fungi. The studies included MIC testing, thiol inhibition of activity, intracellular leakage, oxygen consumption, incorporation of 3H-uridine, scanning electron microscopy, inhibition of enzyme activity (papain) and in vitro oxidation of thiols to disulfides. It appears that the primary mode of action of bronidox is the same as, or similar to, that of bronopol, i.e. the oxidation of essential protein thiol causing inhibition of enzyme activity and subsequent inhibition of microbial growth.

Anti-Bacterial Agents↗

PubMed1980

A comparison of social skills training and contingent attention to improve behavioural deficits of chronic psychiatric patients.

Twelve chronic psychiatric patients were treated with either social skills training or contingent attention to improve behavioural assets or deficits noted on the ward by independently trained raters blind to experimental conditions. Treatment was applied across groups using a multiple-baseline format. Inspection of the data revealed that clinically significant improvements in socially appropriate assets and deficits observed on the ward resulted with social skills training but no substantiative change accrued due to the contingent attention. The behaviours selected for treatment were those which staff were most willing to reinforce. This variable may account, in part at least, for the generalization of treatment effects to the natural environment with persons who received social skills training.

Adult↗

PubMed1979

Ecthyma gangrenosum.

Explore the source record for details and available documents.

Anti-Bacterial Agents↗

PubMedDate not supplied

Safe laparoscopic cholecystectomy in a community setting, N = 762.

Laparoscopic cholecystectomy (LC) can be introduced into a community with morbidity and mortality rates equal to that of open cholecystectomy. The entire general surgical community of Greensboro, NC, learned the technique of LC on animal models prior to offering this innovation to the community. Over the ensuing 12 months, they served as surgeons or assistant surgeons to each other on 762 LCs with morbidity and mortality rates comparable to open cholecystectomy. This retrospective study examined the first 1 year of experience beginning 8/13/90. This work represents all of the LCs performed in Greensboro, and all of the surgeons participated in this review. All of the surgeries were done with an electrocautery and utilized a 0 degree forward-viewing scope. Cases were performed at two hospitals with a surgeon as both operator and assistant, and no effort was made to exclude high-risk or elderly patients from this procedure. Patients averaged 50 years of age and ranged from 14 to 96 years. Static cholangiograms were performed in 27% of patients. Conversion to open cholecystectomy was seen in 4.8%. There were two cardiac deaths (0.26%) and significant complications were seen in 3.4%. Seven patients required reoperations. There were no major common bile duct injuries. This retrospective review indicates that this new procedure can be introduced into a community setting by novice laparoscopic surgeons acting both as operators and assistant with a morbidity and mortality rate comparable to that reported for open cholecystectomy.

Cholangiography↗