Somatostatinoma--the most recently described pancreatic islet cell tumor.
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Adenoma, Islet Cell↗
Biomedical subjects
W Boyko
Publications and source records attributed to W Boyko.
Screening for acquired immune deficiency syndrome with dinitrochlorobenzene.
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Acquired Immunodeficiency Syndrome↗
Lichen spinulosus with immunofluorescent studies.
A typical case of lichen spinulosus in a 15-year-old boy is described. Keratotic papules and plaques occurred on the knees, elbows, and lower legs. A biopsy showed follicular hyperkeratosis consistent with lichen spinulosus. Studies for immunofluorescence demonstrated linear IgM at the basement membrane zone without colloid bodies. The relationship of lichen spinulosus and lichen planus is discussed. The patient responded to treatment with a salicylic acid gel.
Adolescent↗
Lymphomatoid granulomatosis presenting as polyarthritis.
Polyarthritis in lymphomatoid granulomatosis is rare. We report a patient with lymphomatoid granulomatosis who presented with polyarthritis and nodular cutaneous lesions.
Adult↗
The intestinal bypass: arthritis-dermatitis syndrome.
Of the 31 patients who developed polyarthritis following jejunoileal bypass for obesity, 24 had cutaneous vasculitis (urticarial, pustular, and nodular), 11 paresthesias, 10 Raynaud's phenomenon, and 1 pericarditis. Blind loop symptoms (14 of 26 patients), cryoglobulinemia (10 of 28), and immune deposits in biopsied skin lesions (5 of 7) support the theory of a relationship between bowel bacteria and immune complexes. Treating the blind loop with antibiotics and sphincteroplasty to prevent bacterial reflux into the blind loop helped 5 of 10 and 6 of 9 patients, respectively. A comparison is made to other bowel associated arthritides.
Anti-Bacterial Agents↗
Specificity of antinuclear factor testing: what does specific mean?
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Adolescent↗
Aldosterone-binding globulin-induced hypertension in the rat. A new experimental model.
A thermostable urinary homologue of the plasma aldosterone-binding globulin (ABG), designated ABG-TsU, was isolated and purified by differential ultrafiltration, ion exchange chromatography, and gel filtration to electrophoretic homogeneity. Scatchard plot analysis using highly purified ABG-TsU demonstrated reversible high-affinity low-capacity binding at separate sites for aldosterone and dehydroepiandrosterone sulfate (DHEA-SO4). ABG-TsU injected intraperitoneally (i.p.) in male rats resulted in sustained hypertension after 5 to 8 days, characterized after 12 days by no changes in plasma Na+ K+, aldosterone, or plasma renin activity (PRA). No histological changes could be detected in the kidneys, brains, or hearts, nor evidence of adrenocortical hyperplasia. This hypertension appears to be aldosterone-dependent since it is prevented by bilateral adrenalectomy or administration of a spironolactone, but not by adrenalectomy when aldosterone is given concomitantly with ABG-TsU. Hemodynamic characterization of this hypertension was carried out in rats after treatment with ABG-TsU or saline i.p. for 14 days. Cardiac output (CO) was measured using the reference sample microsphere method. ABG-TsU-treated rats had significantly higher mean arterial pressure (MAP), systolic blood pressure (SBP), diastolic blood pressure (DBP), and CO, while no difference in total peripheral resistance (TPR) was detected. This new animal model of borderline essential hypertension (EH) induced by ABG-TsU, which has a reversible high-affinity binding for aldosterone, results in adrenal-dependent hypertension due at this early phase to an increase in CO without any change in TPR, which remains inappropriately normal.
Adrenalectomy↗