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W Bräutigam

Publications and source records attributed to W Bräutigam.

At least 19 recordsLinked to original sources
PubMed2006

[Psychotherapy in the life sciences].

In the 150 years since psychotherapies were theoretically founded and first practised, changes have occurred in the understanding of humans from concepts based on physical sciences to concepts rooted in biologic life sciences. Biopsychosocial knowledge of the way human nature links with environmental factors has resulted in new views on the causes of psychological disorders and the tasks of psychotherapy. The main selective processes of adjustment to the environment take place with genetic variations between the 6th and 20th years of life and in further developments until death. Psychotherapy has to overcome pathologically distorted impressions of the environment. Latent abilities and neglected options need to manifest themselves for patients to find a new outlook on life.

Biological Science Disciplines↗
PubMed1993

Mechanisms of adherence of Candida albicans to cultured human epidermal keratinocytes.

We established an in vitro adherence model with primarily cultured human keratinocytes as target cells which allows for the investigation of the molecular mechanisms that are responsible for Candida albicans host cell attachment in the initiation of cutaneous candidosis. The extent of C. albicans binding to cultured human keratinocytes was dependent on the yeast inoculum size and the incubation temperature. Heat and paraform-aldehyde treatment of yeasts completely abolished the binding activity of C. albicans. Of the different Candida species tested, C. albicans was by far the most adhesive species. C. albicans adherence was blocked by the acid protease inhibitor pepstatin A and the metabolic inhibitor sodium azide. The latter, however, was much less effective when yeasts were preincubated, suggesting that sodium azide was mainly acting on the keratinocytes. The extracellular matrix protein fibronectin was slightly inhibitory, whereas the fibronectin-derived peptides RGD and RGDS were not able to prevent attachment. PepTite-2000, another RGD-containing synthetic peptide, reduced C. albicans adherence by a margin of 25% (P < 0.005). CDPGYIGSR-NH2, which is a synthetic adhesive peptide derived from the laminin B chain, was much more efficient in its inhibitory activity than the RGD peptides and reduced C. albicans adherence to cultured human keratinocytes up to 76% (P < 0.001). Laminin itself and the synthetic pentapeptide YIGSR were less active. A dose-dependent reduction in adherence was also observed with collagen type III. Additionally, saccharides were tested for their potential to inhibit C. albicans attachment to keratinocytes. The most potent competitive saccharide inhibitors of C. albicans adherence to human keratinocytes were the amino sugars D-(+)-glucosamine and D-(+)-galactosamine with one isolate of C. albicans (4918) and D-(+)-glucosamine and alpha-D-(+)-fucose with another C. albicans isolate (Sp-1). Collectively, our data suggest the existence of multiple molecular mechanisms such as protein-protein, lectin-carbohydrate, and yeast-yeast coaggregational interactions that are responsible for optimal C. albicans attachment to cultured human keratinocytes.

Amino Acid Sequence↗
PubMed1991

[Attachment and sexuality in psychoanalytic theories and practice].

Based on Parin's statement that sexuality has disappeared in psychoanalysis both in theory and practice, the classical libido theory is compared to empirical observations made in infants and here especially the theories of Bowlby. Both the concept of sexual climax in early childhood and the concept of sexual drives as a fundamental motivation for the psychic development are not on agreement with empirical studies carried out in infants and the findings of psychobiology and ethology. Bowlby describes the relationship between infant and mother as a bipersonal binding which begins during the first months of life. The child does not strive for sexual stimulation of erogenous zones but rather for tactile, acoustic and visual responses as well as physical contact and tranquility related to one known and trustworthy person. This binding is totally different to the sexual relationship which evolves during adolescence and in which binding takes place between persons of the same species but to whom no relation had existed during early and later childhood. It is important for the psychotherapist that he be able to distinguish between being an object of the childish wish for binding or of adult sexual desires.

Adult↗
PubMed1984

Indication in psychotherapy on the basis of a follow-up study.

The problem of indication is a central one of psychotherapy research. Unfortunately up to now only few scientific results contribute to a therapist's decision in selecting patients for a specific therapeutic setting. Thus, indication and outcome research should be combined. A critical view on traditional research strategies demonstrates that psychotherapy research should replace the ideal of normative and general rules by the rational investigation of one's own therapeutic practice. From this point of view some results of the Heidelberg Follow-Up Project of 110 psychotherapies which were started on an inpatient and continued on an outpatient basis are presented. Based on the therapeutic changes of these 110 patients the question is investigated whether the decisions of the indications correspond with the therapeutic goals of the treatment models. Moreover, the question is discussed what kind of success a specific treatment model offers for 'problem patients'.

Adaptation, Psychological↗
PubMed1984

[Values and goals in psychoanalytic therapy 1984].

The purpose of psychoanalytic therapy (quite nonproblematic at the beginnings of psychoanalysis) as well as the conception of the values imminent in the process of treatment have been extended more and more toward the patient's personality structure and his acceptance of himself. Moreover, under the influence of work, oriented on theoretically conceived methods, the factors of the very process of treatment-perception, regression, catharsis etc.--have often been made into an aim in themselves and into a purpose. Consequently there is a certain danger that the therapeutic responsibility toward the patient's social milieu is being neglected. In the present state of availability of psychiatric care the analyst is involved in the treatment of patients suffering from a wide range of disorders to which corresponds an equally wide range of values and aims. It is discussed in how far the present school-like organization of psychiatric training allows for the necessary flexibility to adequately deal with the various expectations concerning values and aims in different patients.

Germany, West↗
PubMed1979

New therapeutic approaches to psychosomatic patients: verbal and preverbal.

Many of the patients passed on to us are not in a position to begin with a course of treatment aiming at introspection. Here we think that inpatient psychotherapy is a valuable preparation and initiation to the psychotherapeutic process. In a therapeutic community informal contacts with other patients can provide stimuli facilitating the transposition of physical complaints or concretistically experienced life situations. Concentrative movement therapy, group therapy and other methods are helpful to the psychosomatic patient, so as to bring about an awareness of the problematical nature of own views and attitudes.

Educational Status↗