Biomedical subjects
Publications and source records attributed to W Bullock.
Indium-labeled lymphocytes were examined for response to a variety of mitogens, ability to synthesize immunoglobulins, mitotic index, and presence of chromosome aberrations at a range of exposures from 0.2 to 500 muCi/10(8) cells. Results of all four tests were found to be abnormal when the lymphocytes were labeled with 111In activities well within those employed for diagnostic testing.
Quantitation of interleukin 1 production by adherent mononuclear cells from peripheral blood was performed in patients with tuberculoid and lepromatous forms of leprosy. Cells from patients with tuberculoid leprosy either secreted interleukin 1 spontaneously or produced amounts within the normal range in response to lipopolysaccharide stimulation. Conversely, stimulated cells from lepromatous patients failed to produce interleukin 1 in 5 of 13 (38.5%) cases.
A computerized infertility data registry form has been developed in order to facilitate the storage of a large amount of reproductive data to allow subsequent analyses pertinent to the managment of the infertile couple. This abstract form of the patients' medical records had been readily applied to computer analysis using the SPSS reporting system. The abstract can be utilized both for the facilitation of patient management and as a means for obtaining a standardized, objective, retrospective review of clinical data. Through the evaluation and standardization of the therapeutic techniques frequently utilized by physicians, the treatment of infertile couples should be improved. Such an approach is essential for anyone involved in today's health care system.
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Recent investigations of caffeine abuse have questioned the indiscriminant use of this commonly accepted drug. In some individuals, chronic excessive caffeine consumption leads to the development of caffeinism, a syndrome which includes increased anxiety, depression, frequency of psychophysiological disorders, and possibly degraded performance. This paper reviews research demonstrating the abuse potential of caffeine. Special attention has been given those factors which mediate the wide individual differences in consumption patterns, susceptibility to abuse, and the varied psychological and physiological responses to this drug. While the development of caffeine abuse is probably best viewed as an idiosyncratic process, general guidelines for the recognition of potential abuse, and caffeinism proper, are offered.