[Combines cytostatic treatment of malignant tumors. (Clinical histological report of 4 cases)].
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Biomedical subjects
Publications and source records attributed to W Busch.
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The influence of a supplement of variously treated straw materials to a ration to dry concentrate (= 1), (untreated = 2, steamed = 3, HCl-treated = 4 and partly hydrolysed = 5) during gestation on fertility and rearing performance, the embryonic survival quota of fertilized ova as well as on some selected metabolites in the blood serum was studied in 3 experiments. The integration of untreated straw meal resulted in significantly diminished performances in comparison to test groups 1 and 5 in all tested parameters of fertility and rearing performance (weight of litter). The best results were achieved in all experiments with rations of concentrate and partly hydrolysed straw meal. The individual test groups the following performance values (number of piglets born alive, weight of litter in kg) were achieved: 1 = 9.3, 12.3; 2 = 6.5, 8.2; 3 = 7.5, 9.6; 4 = 8.6, 12,4; 5 = 10.6, 14.4). Ration specific reactions could only be proved for the parameters glucose and urea out of the metabolites (insulin, glucose, cholesterol, urea tri-iodine thyronine and thyroxine).
The clinical success of a 5-day course of oral moxifloxacin (administered once daily at a dose of 400 mg) was evaluated in 328 patients with acute exacerbations of chronic bronchitis (Anthonisen type 1) in a non-comparative study conducted by chest physicians in private practice. Results were assessed on the basis of clinical parameters and, for the first time in a trial involving oral moxifloxacin, by the surrogate marker of patient satisfaction. Improvement in (and severity of) cough, dyspnoea, chest pain and sputum were scored daily by patients. Cough, chest pain and purulent sputum production improved rapidly within the first 5 days of treatment. At least 90% of patients were satisfied with the antibiotic. The clinical success rate (cure and improvement) for all patients involved (intent-to-treat analysis) was 90.5%. The most commonly experienced adverse events were gastrointestinal related, with diarrhoea the most frequent of these (2.7% of all patients).
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This is a retrospective study on 2 008 abdominal fetal ECGs of 1 005 patients. Standard values of R-peaks in the fetal ECG depending on the weeks of pregnancy are figured out. For the first time these standard values are shown on a percentile table and a percentile curve group. Depending on this standard values the frequency of fetal postmaturity is calculated. If the 90th percentile values for the R-peaks amplitude has been exceeded, then there is a 32% probability of severe fetal postmaturity in the pregnancy time of more than 290 days p.m., and a 20% probability if the pregnancy time is between 270-290 days p.m. Meconium has been observed in 44% of all cases, if pregnancy was prolonged more than 290 days p.m. and if in addition the R-amplitude was higher than the 90. percentile value. The abdominal fetal ECG therefore is a good additional method in cases of prolonged pregnancy to recognize fetal postmaturity.
The results of our investigations revealed that in 68% of cases the treatment of patients with diffuse peritonitis with ampiox, gentamicin and metronidazole led to arresting the infectious process and to a considerable decrease in microbial contamination of the abdominal cavity. The use of cephalosporins and metronidazole proved to be effective in 85% of cases. In this treatment a considerable decrease in the amount of aerobic and anaerobic bacteria in peritoneal exudate was registered. In the process of treatment with cyprophloxacin positive clinical and microbiological dynamics were observed in all patients.
These investigations revealed that the treatment of patients with generalized peritonitis with ampiox, gentamicin and metronidazole, as well as with cephalosporins and metronidazole, led to the aggravation of dysbiotic disturbances in normal intestinal microflora, observed in these patients before treatment. Ciprofloxacin had a selective decontaminating effect on the intestine, which facilitated the decrease of suppuration in postoperative wounds.
In 11 patients with diffuse peritonitis and 39 patients with general peritonitis the microflora of peritoneal exudate and the sensitivity of isolated microorganisms to antimicrobial preparations were studied. The study revealed that in the total number of microorganisms isolated from peritoneal exudate enterobacteria prevailed in patients with diffuse peritonitis and bacteroids, in patients with general peritonitis. Enterobacteria were most sensitive to ciprofloxacin and claforan, while bacteroids, to ciprofloxacin; at the same time 15.4% of the bacteroid strains under study were resistant to ciprofloxacin.