PubMed Health⌕ Search

Biomedical subjects

W C Chen

Publications and source records attributed to W C Chen.

At least 19 recordsLinked to original sources
PubMed1992

[Improving the curative effect of chemotherapy on gynecological malignant tumor by catheterization of internal iliac artery].

Seventeen cases of gynecological malignant tumor received 27 infusion chemotherapy by selective catheterization via internal iliac artery. Among them, 14 cases (82.4%) were cancer of advanced stage. All of the cases were followed up. 77.8% of cases showed short-term good response. The intermittent mean duration without tumor growth was 12.5 months. The determination of platinum confirmed that the vascular embolism chemotherapy of tumor is one of the best approaches for pelvic tumors.

Adult↗
PubMed1992

Congenital bronchoesophageal fistula in the adult: a case report.

The case of a 50-year-old woman with congenital bronchoesophageal fistula is presented. The patient had symptoms of hemoptysis provoked by ingestion of liquids for 2 years. A barium swallow examination showed a bronchoesophageal fistula communicating between the middle third of the esophagus and right intermediate bronchus. An orifice of the fistula at the esophagus was revealed by esophagoscopy. The clinical and operative features and diagnosis of congenital origin are discussed.

Bronchial Fistula↗
PubMed1991

Cell-cell contacts mediated by E-cadherin (uvomorulin) restrict invasive behavior of L-cells.

L-cells were cotransfected with plasmids coding for mouse E-cadherin (uvomorulin) and the neophosphotransferase gene, and stable transfectants expressing E-cadherin at the cell surface were selected and cloned. Control transfection was done with the neophosphotransferase gene alone. The invasive migration of transfected and untransfected L-cells into three-dimensional collagen gels was then analyzed. L-cells not expressing E-cadherin migrated efficiently into the gels, whereas invasion of the E-cadherin-expressing L-cells was restricted in a cell density dependent manner. At sparse density, when the cells exhibited little cell-cell contacts, no difference was observed between the level of invasion of the cadherin-expressing cells and the control cells. However, with increasing cell density, decreasing amounts of the cadherin-expressing cells but increasing amounts of the control cells migrated into the gels. At confluent density hardly any cadherin-expressing cells were able to migrate into the gels. The inhibition of the invasion of the cadherin-expressing cells could be reverted if confluent cells were cultured in the presence of monoclonal antibodies against E-cadherin. Since the expression of E-cadherin did not influence the invasive mobility of single cells, these results indicate that E-cadherin-mediated cell-cell contacts inhibited invasive cellular migration. Time-lapse videoscopy and studies of cell migration from a monolayer into a cell-free area demonstrated that the restricted invasion could be explained by contact inhibition of cell movement of the cadherin-expressing cells.

Animals↗
PubMed1991

Factors influencing radiation exposure during the extracorporeal shock wave lithotripsy.

A prospective evaluation of 89 consecutive sessions of extracorporeal shock wave lithotripsy (ESWL) was undertaken to try and find the best way of minimising the amount of exposure to radiation. Forty-two patients were randomly allocated to undergo ESWL treatment by experienced surgeons (group A), and 47 to undergo the treatment by inexperienced surgeons (group B). The mean calculated entrance radiation exposure was 3.01 rads (group A: 2.64 (0.97) rads, range 1.00-4.48, group B: 3.38 (0.86) rads, range 1.11-5.75). Among factors that influenced radiation exposure, the tissue: air ratio should be borne in mind and the level of skill in controlling movement of gantry was the most important in reducing the exposure to radiation.

Adult↗
PubMed1991

Diagnostic value of cerebrospinal fluid immunoglobulin G (IgG) in pediatric neurological diseases.

A total of 71 cerebrospinal fluid (CSF) specimens with paired serum samples from 16 controls and 55 patients with various neurologic diseases ranging in age from 1 to 15 years old were studied using a rate nephelometer to measure their immunoglobulin G (IgG) and albumin levels in both their CSF and serum. The patients included 15 cases of encephalitis, 6 cases of purulent meningitis, 20 cases of aseptic meningitis, 2 cases of multiple sclerosis and 12 cases of other noninflammatory neurologic diseases. The values of the CSF IgG quotient, IgG index, and de novo central nervous system (CNS) IgG synthesis were then calculated for each subject. In the control group, the mean values were as follows: CSF IgG, 1.45 mg/dl; IgG quotient, 6.2%; IgG index, 0.55; and de novo IgG synthesis, -1.17 mg/day. Those with CNS inflammatory diseases had significantly higher CSF IgG levels and IgG quotients compared with controls (p less than 0.05). The IgG index was selectively elevated in cases of encephalitis (p less than 0.005). The values for de novo IgG synthesis showed significant increase in all types of CNS inflammatory diseases except for the group with aseptic meningitis. In the noninflammatory diseases, none of the CSF parameters revealed any significant differences from those of the control group. Six cases (40%) of encephalitis showed normal CSF protein value, but an abnormal IgG component, IgG index and de novo IgG synthesis. Quantitation of IgG and other derivatives in CSF gives a sensitive supplementary reference for the detection of CNS infection.

Adolescent↗
PubMed1991

[Scavenging of probimane on semiquinone free radical formation by doxorubicin in rat heart].

Probimane, dl-bis (4-morpholin-methyl 3,5-dioxopipweazin-1-yl) propane first synthesized in China, is a dioxopiperazin compound with antineoplastic, antimetastatic and radiopotentiating activities. In order to evaluate the mechanisms of cardiotoxicity protective action of probimane, the free radical induced by doxorubicin were analysed by electron spin resonance (ESR) techniques. Our studies showed that doxorubicin stimulated the formation of semiquinone free radicals in the rat heart homogenate and heart cell mitochondria systems, and probimane inhibited the free radical formation in both systems, with the dose-dependent and time-dependent responses. The inhibitory rates of doxorubicin free radical formation in rat heart homogenate system by probimane 0.6 mmol.L-1 at time of 3, 5, 10, 15, 30, 45 and 60 min were 44.6%, 43.0%, 51.5%, 74.3%, 68.1%, 56.1% and 39.9% respectively. The inhibitory rates of semiquinone free radical formation in mitochondria system by probimane at the concentration of 0.02, 0.06, 0.6, 1.2 and 2.4 mmol.L-1 were 17.07%, 29.87%, 63.95%, 64.62% and 83.64%, respectively. Probimane had no effect on NADH2, but inhibited NADH dehydrogenase activity at higher concentration.

Animals↗
PubMed1990

Polycystic kidney of autosomal dominant inheritance, polycystic liver and congenital hepatic fibrosis in a single kindred.

A family with clear evidence of concomitant congenital hepatic fibrosis, polycystic liver and adult-type polycystic kidney is reported. The autosomal dominant inheritance of polycystic kidney in association with either liver cyst or hepatic fibrosis in this family suggests that various combinations of hepatic and renal fibrocystic lesions are possible to occur. Additionally, in the proband a very rare association of congenital hepatic fibrosis and cerebral aneurysm was present.

Adult↗
PubMed1990

Pulmonary infarction presenting as aseptic cavitation.

A case of pulmonary infarction presenting as aseptic cavitation was reported. Basically, the patient suffered from rheumatic heart disease, mitral stenosis and insufficiency, and atrial fibrillation with predominant right heart enlargement. Hemoptysis, chest pain and dyspnea were present. Chest film simulated a thin wall lung abscess. The clinical picture suggested aseptic cavitation, which was confirmed by 99mTc-MAA lung scan.

Aged↗
PubMed1990

Retroperitoneal abscesses.

Abscesses developing within the retroperitoneal spaces are complicated serious surgical infections marked by an insidious, occult process lead to considerable mortality and morbidity. In a retrospective review of 39 retroperitoneal abscesses in our hospital. Attention is directed to clinical presentation, diagnosis and treatment. On average, 19.2 days was required to establish the diagnosis and overall mortality is 7.7%. Two patients suffered from complications of discharged sinus and recurrent abscess respectively. Computed tomography (CT) is thought to be the best diagnostic modality of retroperitoneal abscesses. Only 2 patients (5.3%) shows bilateral lesions. Detailed anatomic reviews detailing the pathogenesis of bilateral retroperitoneal abscess are also discussed.

Abscess↗
PubMed1988

Atrial tachycardia, 2:1 alternate Wenckebach periodicity, and atrial standstill.

A case of atrial tachycardia, 2:1 alternate Wenckebach periodicity and atrial standstill is reported in an 80-year-old woman who complained of exertional dyspnea and occasional syncope for two years. Two blocked P' waves appeared after each Wenckebach period suggesting type B alternating Wenckebach phenomenon (Mobitz type II 2:1 A-V block distal, and Wenckebach conduction proximal).

Aged↗
PubMed1988

Complete atrioventricular block, retrograde atrial activation and intra-atrial block.

A case of complete atrioventricular block, retrograde atrial activation, and intra-atrial block was reported. Inhomogeneous inhibition of the atrioventricular junction and the so-called summation of impulses may both act together to make retrograde conduction possible when third-degree atrioventricular block was present. In lead 2, P waves were dome-shaped, and in lead V1, P waves were biphasic; narrow and peaked P waves intermittently appeared, denoting third-degree intra-atrial block. The peaked P waves signified that the right atrium was activated while the left atrium was not depolarized.

Atrioventricular Node↗