Biomedical subjects

W C E Schofield

Publications and source records attributed to W C E Schofield.

8 recordsLinked to original sources

PubMed2007

Mimicking a Stenocara beetle's back for microcondensation using plasmachemical patterned superhydrophobic-superhydrophilic surfaces.

A simple two-step plasmachemical methodology is outlined for the fabrication of microcondensor surfaces. This comprises the creation of a superhydrophobic background followed by pulsed plasma deposition of a hydrophilic polymer array. Microcondensation efficiency has been explored in terms of the chemical nature of the hydrophilic pixels and their dimensions. These results are compared to the hydrophilic-hydrophobic pattern present on the Stenocara beetle's back, which is used by the insect to collect water in the desert. Potential applications include fog harvesting, microfluidics, and biomolecule immobilization.

Animals↗

PubMed2006

A substrate-independent approach for cyclodextrin functionalized surfaces.

6-Amino-6-deoxy-beta-cyclodextrin can be immobilized onto a range of solid surfaces via reaction with a predeposited pulsed plasma poly(glycidyl methacrylate) layer. X-ray photoelectron spectroscopy, infrared spectroscopy, and quartz crystal microbalance measurements have been employed to monitor guest-host interactions between N,N-dimethylformamide or cholic acid and surface-tethered 6-amino-6-deoxy-beta-cyclodextrin barrels.

Biosensing Techniques↗

PubMed2006

Electroless metallization onto pulsed plasma deposited poly(4-vinylpyridine) surfaces.

Pulsed plasma-chemical deposition of poly(4-vinylpyridine) is found to be a highly effective way of functionalizing solid surfaces with pyridine ring centers. These surfaces can be metallized via complexation to Pd2+ ions from solution, followed by autocatalytic electroless deposition of either copper or nickel films.

Journal Article↗

PubMed2006

Rewritable DNA microarrays.

Thiol-terminated single-stranded deoxyribonucleic acids (ssDNA) can be immobilized onto pulsed plasma deposited poly(allylmercaptan) surfaces via disulfide bridge chemistry and are found to readily undergo nucleic acid hybridization. Unlike other methods for oligonucleotide attachment to solid surfaces, this approach is shown to be independent of substrate material or geometry, and amenable to highly efficient rewriting.

DNA, Single-Stranded↗

PubMed2005

Functionalization of solid surfaces with thermoresponsive protein-resistant films.

Pulsed plasma polymerization of N-isopropylacrylamide leads to the deposition of thermoresponsive films. The reversible (switching) behavior of these poly(N-isopropylacrylamide) surfaces has been exemplified by screening the adsorption of fibrinogen and fluorescein isothiocyanate labeled bovine serum albumin proteins by surface plasmon resonance (SPR) and fluorescence microscopy at low and elevated temperatures.

Acrylic Resins↗

PubMed2005

Substrate-independent approach for polymer brush growth by surface atom transfer radical polymerization.

A simple method for growing polymer brushes by atom transfer radical polymerization (ATRP) off solid surfaces has been devised. This entails pulsed plasmachemical deposition of a halogen-containing initiator layer, followed by either organic or aqueous phase controlled surface polymerization. The wide-scale applicability of this approach is exemplified by functionalizing flat substrates, microbeads, and nonwoven textiles.

Journal Article↗

PubMed2005

Poly(N-acryloylsarcosine methyl ester) protein-resistant surfaces.

A new class of protein-resistant film based on N-substituted glycine derivatives is described. Pulsed plasma deposited poly(N-acryloylsarcosine methyl ester) coatings are shown to be resistant toward the adsorption of fibrinogen and lysozyme. Deposition and UV irradiation of the polymer through a masked grid are found to be effective ways for generating negative and positive image protein arrays, respectively, onto a range of different substrate materials.

Adsorption↗

PubMed2005

Rapid polymer brush growth by TEMPO-mediated controlled free-radical polymerization from swollen plasma deposited poly(maleic anhydride) initiator surfaces.

Pulsed plasma-chemical deposition of poly(maleic anhydride) is shown to be a substrate-independent method for functionalizing solid surfaces with initiator sites for nitroxide-mediated controlled free-radical graft polymerization. Swelling of the initiator film via aminolysis can lead to grafted polymer brushes that are 1 order of magnitude thicker than those obtained by existing methods on solid surfaces.

Journal Article↗