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Biomedical subjects

W C Hsieh

Publications and source records attributed to W C Hsieh.

At least 109 records · Page 6Linked to original sources
PubMed1984

Asian multicenter trial of cefoperazone in respiratory tract infection.

The safety and clinical efficacy of cefoperazone were evaluated in a multicenter trial conducted at institutions in Japan, Korea, and Taiwan. Cefoperazone was given as the sole antibiotic for 481 respiratory tract infections in 476 patients. An overall satisfactory clinical response was achieved in 73.7% of patients. Cefoperazone was effective in 78.9% of cases of pneumonia, 81.1% of acute exacerbations of chronic bronchitis, and 69.4% of bronchiectasis with infection. A satisfactory bacteriological effect was obtained in 93.2% of cases in which Haemophilus influenzae was isolated, 70.2% of Klebsiella infections, and 84.6% of infections with Streptococcus pneumoniae. Although the eradication rate was only 38.6% in patients with Pseudomonas aeruginosa, the success rate increases to 59.1% if patients showing a decrease in the number of organisms are included. Cefoperazone was effective in 63.5% of the 148 cases that had failed to respond to treatment with other antibiotics. Adverse reactions occurred in 8.0% of patients and consisted primarily of rash, diarrhea, and fever. Cefoperazone appears to be an extremely useful injectable antibiotic for the treatment of respiratory tract infections in hospitalized patients.

Adolescent↗
PubMed1984

[Typing of Bacteroides fragilis by bacteriocin production].

Sixty-four strains of Bacteroides fragilis isolated from clinical specimens were tested for their bacteriocin production. It showed that 65.6% of them produced bacteriocin(s) and gave different patterns of inhibition. Among them 9 with clear inhibition zones were chosen as the indicator strains. With this indicator s,et 75.2% of 109 clinically isolated B. fragilis strains could be typed, with type 482 as the predominant type. The colonial dissociants gave the same bacteriocin type, but small and opaque colonies tend to lose their bactericidal ability.

Bacteriocins↗
PubMed1982

Combined in vitro activity of amphotericin B and 5-fluorocytosine against Cryptococcus neoformans and Candida albicans.

The in vitro combined antifungal activity of amphotericin B (AMB) and 5-fluorocytosine (5-FC) against 10 strains of Candida albicans and 8 strains of Cryptococcus neoformans was studied. Serial twofold dilutions of AMB (0.1 to 12.8 micrograms/ml) were tested with serial twofold dilutions of 5-FC (0.39 to 400 micrograms/ml) by using the broth dilution method. A synergistic effect was seen for 17 strains with 50 micrograms of 5-FC per ml added to AMB. Only one strain was killed by 0.8 micrograms per ml or less of AMB alone, whereas all strains were killed with the addition of 50 micrograms of 5-FC per ml.

Amphotericin B↗
PubMed1981

Antibiotic susceptibility patterns of Staphylococcus aureus and Staphylococcus epidermidis.

The susceptibilities of 100 clinically significant isolates of Staphylococcus aureus and 45 clinically significant isolates of Staphylococcus epidermidis against various antibiotics were determined by the agar dilution method. Rifampin was the most active of all agents tested against both S. aureus and S. epidermidis. Among the beta-lactam antibiotics, penicillin G was least active, but had the lowest MIC in range. All strains of S. aureus were susceptible to cloxacillin and cephalothin at concentrations of 2 and 4 mcg/ml, respectively. Cloxacillin was less active against S. epidermidis, while cephalothin was more active. Minocycline was more active than doxycycline and tetracycline. Chloramphenicol was not only almost as poor in activity against S. aureus as tetracycline, but also the least active of all agents tested against S. epidermidis. Gentamicin was the most active aminoglycoside. Erythromycin, lincomycin and clindamycin showed the bimodal pattern of susceptibility. These results suggest the marked variability in antibiotic susceptibility of staphylococci.

Anti-Bacterial Agents↗
PubMed1975

Evaluation of antibacterial activities of cephalosporin antibiotics: cefazolin, cephaloridine, cephalothin, and cephalexin.

The antibacterial activities of 4 cephalosporin antibiotics, cefazolin, cephaloridine, cephalothin and cephalexin, against 330 isolates of bacteria from patients at National Taiwan University Hospital, were determined by an agar plate dilution technique. Cephalosporins possess strong antibacterial activity against gram-positive bacteria except Enterococci. Staphylococcus aureus is the most susceptible among the organisms tested. More than 90% of Staphylococcus aureus strains are suppressed by cefazolin, cephaloridine and cephalothin at the concentrations of 3.13 mug/ml or less, except that 49.1% are suppressed by cephalexin. The relative potency of cephalosporins against Staphylococcus aureus in decreasing order is cephaloridine, cephalothin, cefazolin, and cephalexin. The gram-negative bacilli, Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis are less susceptible to cephalosporins than the gram-positive cocci. Among the cephalosporins, cefazolin is the most active against the gram-negative pathogens tested. The relative potency of antibacterial activity of cephalosporins against E. coli in decreasing order is cefazolin, cephaloridine, cephalexin, and cephalothin. One hour after the intramuscular injection of 500 mg of cefazolin, the maximum concentration of 33.3 mug/ml is reached in the serum. The sufficient high levels are sustained for 8 hours. Very high concentrations of cefazolin are also found in the urine.

Adult↗