Biomedical subjects
W C James
Publications and source records attributed to W C James.
Preventive medicine as a component of the office visit--is it time for a change?
A routine visit to a physician's office generally is composed of the reason for the visit; attention to ongoing medical problems; and preventive medicine considerations. A separate visit for preventive medicine activities can be helpful. A computer-generated annual birthday greeting to patients that suggests specific preventive medicine studies would result in a more problem-focused office visit and greater precision in the execution of preventive medicine activities.
Signs of cellular immunosuppression correlate with HLA-DR phenotypes in healthy HIV-negative homosexuals: preliminary findings.
Twelve healthy, anal-receptive, homosexual Caucasian males who were seronegative for HIV antibody were typed for HLA-DR antigens. Flow cytometry was used to immunophenotype peripheral blood lymphocytes bearing the CD4, CD8, LEU7, and combined CD8 and LEU7 antigens. These individuals had reported a large number of sexual partners within a five-year period preceding this study. Each individual was assigned a score based on the Hardy-Weinberg frequency of their HLA-DR phenotype in the Caucasian population. The larger the value of this score, the more common the HLA-DR phenotype, the smaller the score, the rarer the phenotype in the population at large. A significant inverse correlation was observed between this score and the proportion of lymphocytes with CD8 and LEU7 antigens. Lymphocytes bearing these two antigens have in vitro suppressor activity and are elevated in patients with human immunodeficiency virus (HIV) infection. The inverse association between CD8+/LEU7+ cells and frequency of HLA-DR phenotypes is consistent with the hypothesis that individuals with rarer phenotypes whose partners are drawn from the population at large are more likely to be challenged during anal insemination, which results in immunosuppression (alloantigenic challenge hypothesis). On the other hand, it is possible that an association exists between certain HLA-DR phenotypes and immune status. Although these observations were made in a very small sample, we believe that the strength of this association provides justification for further investigation into the possibility that alloantigenic challenge may increase the risk for infection, if exposed to HIV, and augment the immunosuppressive action of HIV once significant infection has occurred.
Electrocardiographic artifacts caused by defective marker circuitry.
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Placement of free gingival grafts on denuded alveolar bone. Part I: clinical evaluations.
Fourteen patients were examined and determined to lack an adequate zone of attached gingiva in the mandibular incisor region. Each patient was treated on the left side of the mandible by placement of a free gingival graft on denuded bone and 12 of the 14 patients received a free gingival graft on retained periosteum in the right mandibular anterior region. Two patients were treated on the right side by either bone denudation or periosteal bed preparation without graft placement to permit histological evaluation of wound healing under these circumstances. Grafts were retained for time intervals from 1 week to 24 weeks. All patients were evaluated clinically for graft "take", graft healing, graft shrinkage, and graft mobility.
Placement of free gingival grafts on denuded alveolar bone. Part II: microscopic observations.
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A method for securing conservative block section in the mandibular anterior region.
A conservative method for removal of histologic block tissue sections has been presented. Its application permits the operator to conserve a portion of lingual alveolar bone in the mandibular anterior region to allow maintenance of a sufficient amount of ridge bone and tissue for construction of a functional and esthetic removable or fixed prosthetic appliance. This block section procedure may be modified to permit more conservation of human tissues in those studies involving human subjects.
Colon cancer detection using guaiac screening.
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American association of mental deficiency presents panel on training the mentally retarded deaf.
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