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Biomedical subjects

W C Klingensmith

Publications and source records attributed to W C Klingensmith.

At least 73 records · Page 4Linked to original sources
PubMed1978

Tuberculous meningitis of the Sylvian fissure.

A 66-year-old woman had autopsy-proven miliary tuberculosis, with regional involvement of the meninges of the left Sylvian fissure. Radionuclide studies of the brain demonstrated the unusual findings of increased perfusion to the left hemisphere and linear increased activity corresponding to the left Sylvian fissure. Computed tomography of the brain was initially within normal limits at a time when the radionuclide study was clearly abnormal.

Aged↗
PubMed1978

Renal uptake of 99mTc-sulfur colloid in congestive heart failure.

Renal uptake of 99mTc-sulfur colloid during liver and spleen imaging was observed in 4 patients; all had moderate to severe congestive heart failure. Four similar patients with this association have been reported. Although the exact mechanism of colloid uptake by the kidneys is not known, an association with congestive heart failure seems likely.

Adult↗
PubMed1978

Visualization of hepatic veins on excretory urography.

The hepatic veins were visualized on the early nephrogram film of an excretory urogram in a patient with tetralogy of Fallot. A nuclear angiocardiogram showed pulsatile reflux of blood from the right atrium into the hepatic veins.

Adolescent↗
PubMed1977

Phantom kidney in technetium-99m DTPA studies of renal blood flow: case report.

Renal perfusion, filtration rate, and excretion can be evaluated with technetium-99m diethylenetriamine pentaactate (Tc-DTPA) using immediate and delayed imaging. Two cases are presented in which the immediate images reveal a bilateral distribution of radiotracer characteristic of bilateral renal perfusion, but the delayed images showed no evidence of filtration or excretion on one side. There was congenital absence of the kidney on that side in one case and surgical absence in the other. The apparent renal perfusion on the side of the absent kidney was probably attributable to perfusion of small bowel occupying the renal fossa.

Adolescent↗
PubMed1976

Delineation of peripheral bone infarcts in a child with a rare hemoglobinopathy (SOArab) and purpura fulminans: case report.

A 27-month-old patient with SOArab hemoglobinopathy complicated by purpura fulminants was studied with 99mTc-pyrophosphate. The study showed an absence of radiotracer in the bones of both feet and the distal portions of both hands, along with an increased concentration of radiotracer proximal to the regions of absent radiotracer. Subsequent amputation of the distal portions of all four extremities was necessary because of dry gangrene. The amputation site in each extremity (selected on clinical grounds only) corresponded closely to the junction of absent and increased bone radiotracer, suggesting that bone imaging may be used as an aid in determining the extent of nonviable tissue in similar patients.

Bone and Bones↗
PubMed1976

Factors affecting the uptake of 99mTc-sulfur colloid by the lung and kidney.

Occasionally patients injected with 99mTc-sulfur colloid (TSC) for liver--spleen imaging show increased uptake by the lungs or kidneys. In animals, increased lung uptake of TSC can be produced by injecting endotoxin intraperitoneally. Using an intraperitoneal endotoxin model, we studied the effect of heparin on dose-response curves for TSC uptake by the lungs and kidneys. Over a dose range of 1 mug to 10 mg of endotoxin, TSC uptake by the lungs increased progressively; heparin had no effect. In the kidneys, endotoxin in doses from 1 mug to 1 mg resulted in an increased TSC uptake which was less marked than that in the lungs and which was also unaffected by heparin. However, at a dose of 10 mg of endotoxin, a marked increase occurred in TSC uptake by the kidneys, and this could be prevented by heparin. Although the increased TSC uptake by the kidneys at lower doses of endotoxin and by the lungs at all doses is probably not related to intraavascular coagulation, the marked increase in TSC uptake by the kidneys at 10 mg of intraperitoneal endotoxin probably is related to intravascular coagulation, possibly by entrapment in fibrin deposits in the renal capillaries.

Animals↗
PubMed1975

Widespread abnormalities of radiocolloid distribution in patients with mycopolysaccharidoses.

Mucopolysaccharidoses (MPS) are inherited disorders of lysosomal enzymes. We have examined the sites of accumulation of intravenously injected 99mTc-sulfur colloid in order to assess the regional distribution of phagocytic function in ten patients with MPS: three with Type VI (Maroteaux-Lamy). Increased lung uptake was observed in 22 of 40 studies (55%) on the five patients with MPZ Type II but in none of the 38 studies on patients with other MPS types. All MPS patients had diffuse recticuloendothelial (RE) marrow hypoplasia, despite normal or nearly normal hematocrits and hemoglobin levels, suggestion dissociation of the phagocytic and erythropoietic elements of the marrow. The eight patients with MPZ Types I and II all had hepatomegaly and increased splenic uptake. Seven of these patients with MPS Types III and VI did not have hepatosplenomegaly. These studies indicate that the lysosoma enzymic defect of MPS results in widespread abnormalities of the distribution of phagocytic function in the liver, spleen, bone marrow, and probably the lung as well.

Adolescent↗