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Biomedical subjects

W C Lauerman

Publications and source records attributed to W C Lauerman.

27 records · Page 2Linked to original sources

Age-related disk degeneration: preliminary report of a naturally occurring baboon model.

Anteroposterior and lateral radiographs of 126 adult baboons were reviewed. The mean age was 15.7 years (range 6-30 years). Evidence of disk degeneration, to include disk-space narrowing, osteophyte formation, endplate changes, and facet joint arthropathy, was noted, and a grading scale, grades 0-3, was used to assign each animal an overall grade for degree of disk degeneration. Lateral radiographs were measured in the area of maximal sagittal plane curvatures. Radiographic review demonstrated a strongly positive correlation between the age of the baboons and the degree of degenerative change (p less than 0.0001), between the degree of kyphosis and the degree of degenerative change (p less than 0.0001), and between the age of the animal and the degree of kyphosis (p less than 0.001). This pilot study demonstrates plain radiographic confirmation of a naturally occurring primate model of disk degeneration, the first such model described, and is the basis for further investigation into magnetic resonance imaging and histopathologic confirmation of this model.

Aging↗

The histomorphologic sequence of dural repair. Observations in the canine model.

This study was undertaken to investigate the histopathologic events of the dural reparative process. Uniform 2-mm dural defects were created in adult beagles, repaired, and then examined in a 6-week period. Primary fibroblastic bridging of the durotomy was not seen until Postoperative Day 6, and it was not until Postoperative Day 10 that ablation of this defect was uniformly seen. Cerebrospinal fluid egress through the dural defects was prevented in the vast majority of cases by the formation of an internal patch composed of proliferative elements of pia and arachnoid mater.

Animals↗

Management of pseudarthrosis after arthrodesis of the spine for idiopathic scoliosis.

Sixty-three first, second, or third-time repairs of one or more pseudarthroses were done in fifty-one patients who had had an arthrodesis for idiopathic scoliosis. Forty-five of the patients were female and six were male. The average age was 30.2 years. The indications for the sixty-three repairs were pain (twenty-five repairs), progression of the curve (sixteen), both pain and progression of the curve (twelve), and radiographic changes only (ten). Failure of the implant was identified before 27 per cent of the sixty-three procedures. The pseudarthroses were diagnosed an average of 2.8 years after the initial arthrodeses. Sixty-eight per cent of the defects were visible on plain radiographs preoperatively and 32 per cent were identified at operation. During the time between the original arthrodeses and the repairs of the pseudarthroses, the scolioses increased by a mean of 7 degrees and the kyphoses, by a mean of 10 degrees. Harrington distraction was the most commonly used instrumentation (twenty-six [41 per cent] of the sixty-three procedures), and autogenous iliac bone was the most commonly used material for the graft (thirty-three [52 per cent] of the procedures).

Adolescent↗

Spontaneous bilateral rupture of the extensor mechanism of the knee in two patients on chronic ambulatory peritoneal dialysis.

Two cases of patients on Chronic Ambulatory Peritoneal Dialysis (CAPD) who suffered bilateral, spontaneous rupture of the extensor mechanism of the knee are presented. In neither case was the diagnosis readily apparent. Both patients did well with standard surgical treatment. A review of the literature and consideration of the mechanism of tendon rupture is presented.

Adult↗

Primary actinomycosis of the quadriceps.

Primary actinomycosis of the musculoskeletal system is an unusual occurrence. We report the case of a 14-year-old boy with isolated actinomycosis of the quadriceps. Surgical drainage followed by 6 weeks of treatment with oral tetracycline yielded a good result.

Actinomycosis↗

Cervical spine alignment in the immobilized football player. Radiographic analysis before and after helmet removal.

We investigated the effect of football helmet removal on the sagittal alignment of the cervical spine. A quantitative radiographic assessment of relative cervical spine position in subjects immobilized to a standard backboard wearing shoulder pads either with or without a helmet was performed. Comparison was made to a control situation with subjects on a backboard wearing no equipment. Ten subjects were studied using lateral computed tomographic scout films; each subject served as his own control. Radiographs were measured for overall sagittal cervical alignment and the amount of lordosis or kyphosis present within specific segments of the cervical spine. Mean values for each of the three defined situations (no equipment, shoulder pads and helmet, shoulder pads alone after helmet removal) were calculated and subjected to statistical analysis. No statistically significant difference in cervical sagittal alignment was noted when either no equipment or both shoulder pads and helmet were worn. In contrast, a statistically significant increase in cervical lordosis (extension) was found when comparing the control situation to that when only shoulder pads were worn after the helmet had been removed. The majority of this increase occurred in the subaxial spine. Therefore, the authors recommend that football players with a potential cervical spine injury be immobilized for transport with both their helmet and shoulder pads left in place, thereby maintaining the neck in a position most closely approximating "normal."

Adult↗

The use of magnetic resonance imaging in the diagnosis of lumbar disc disease.

Low back pain is a common malady, affecting up to 80% of adults at some time. Our diagnostic capabilities have been markedly improved with the introduction and evolution of magnetic resonance imaging. MRI is an accurate modality in the diagnosis of disc herniation, as well as recurrent disc herniation, degenerative disc disease, and other abnormalities that may present as back pain.

Adult↗