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Biomedical subjects

W C Marshall

Publications and source records attributed to W C Marshall.

At least 19 recordsLinked to original sources
PubMed1988

Eczema herpeticum. Clinical and laboratory features.

Eczema herpeticum (EH) is a potentially life-threatening complication that may occur in children with atopic dermatitis. The clinical and laboratory features of EH as seen in 14 children are reported. The mean age of affected children was 34 months. A rapid viral diagnosis was made in 72 percent of patients. In one-third of patients there was a history of herpes labialis in one or other parent in the previous week. In 28 percent of the children, EH was initially thought to be an exacerbation or impetiginization of the underlying dermatitis. Eleven of 14 children were treated with acyclovir (intravenously in eight, orally in three). All patients recovered without sequelae.

Acyclovir↗
PubMed1985

Congenital trypanosomiasis in a child born in London.

A female infant of 22 months was referred to the Hospital for Sick Children, London, because of delayed psychomotor development. Extensive investigations revealed no cause, but eventually trypanosomiasis was diagnosed. The infant had not been outside the UK, but her mother came from Zaire, where the disease is endemic, but had lived in Kinshasa, where there is no sleeping sickness. It is thought, that the mother may have been asymptomatically infected by a fresh-blood transfusion four years earlier, since no other source of infection was apparent.

Democratic Republic of the Congo↗
PubMed1979

Congenital rubella deafness: a preventable disease.

Over a 4-year period (1972-75) an unselected sample of 568 children aged under 4 years attending the Nuffield Hearing and Speech Centre were tested for rubella antibody. Sensorineural deafness was subsequently diagnosed in 349 of these children, and 83 (24%) of this group had rubella antibody. In contrast, only 19 (9%) of the remaining 219 children in whom sensorineural deafness was excluded had rubella antibody. The seropositive and seronegative children with sensorineural deafness showed striking differences in family history, history of maternal rubella, adverse perinatal events, and presence of other defects. Congenital rubella is an important cause of deafness, and the rubella vaccination programme must be pursued more vigorously if this serious defect is to be prevented in the future.

Abnormalities, Multiple↗
PubMed1979

Immunoglobulin levels in Nigerian cord blood sera.

We have quantified the levels of IgG, IgA and IgM in Nigerian cord blood samples during the dry and the wet seasons. Almost all the samples collected during both seasons had detectable levels of IgG and IgM, while IgA was detected in 71% of those collected in the rainy season and in only 45% of those collected during the dry season. We observed seasonal variations in the levels of each of these immunoglobulins but the variations were not consistent for all three immunoglobulin classes. This suggests that the levels of each immunoglobulin class in the cord blood is probably controlled by different antigenic factors in our environment. The mean values for all three immunoglobulin classes were raised in all our samples above those of UK cord blood samples. This is consistent with earlier reports for samples collected in the tropics. In the paired cord/maternal immunoglobulin estimations, 75% of cord sera had higher levels of IgG than their corresponding maternal samples, suggesting either active transfer of the immunoglobulin across the placenta or increased rate of synthesis or decreased rate of catabolism in utero.

Female↗
PubMed1979

Mycoplasma hominis. A cause of neonatal meningitis.

Two cases of Mycoplasma hominis meningitis in the newborn are described. These infants demonstrate the need to consider M. hominis as a cause of neonatal meningitis, especially if the Gram stain is negative, conventional cultures yield no growth, and there is a history of maternal infection. CSF cultures on appropriate medium can quickly confirm the diagnosis.

Adult↗