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Biomedical subjects

W C Ting

Publications and source records attributed to W C Ting.

12 recordsLinked to original sources
PubMed1987

Polycythaemia after renal transplantation.

The haematological, biochemical and clinical features of six patients with polycythaemia after renal transplantation were studied. The patients had an absolute increase in red cell mass, but normal plasma and whole blood volumes. Primary proliferative polycythaemia was excluded. Polycythaemia developed within one year of transplantation and persisted for 3-7 years. Chronic rejection, renal artery stenosis, severe hypertension and corticosteroid therapy were probably not the cause of the polycythaemia. There were no occlusive vascular lesions during the observation period and venesections were generally not required. The polycythaemia is probably the result of the cumulative production of erythropoietin by the donor and recipient kidneys.

Adolescent↗
PubMed1985

Evaluation of the common conditions associated with eosinophilia.

In an eosinophilic population of 47 boys of the same age, a large proportion (92%) were helminth infested or atopic, or both, compared with 36% of 36 controls. The methods used to detect these conditions were not costly or elaborate, except for the radioallergosorbent test, which was used to measure concentrations of circulating IgE antibodies to atopic allergens. It is suggested that an economical approach to detect helminthiasis and atopy in cases of eosinophilia is adopted using the methods employed here, with skin prick tests replacing the radioallergosorbent test.

Adolescent↗
PubMed1984

Thrombocytopathic purpura associated with eosinophilia.

An acquired bleeding syndrome associated with eosinophilia occurs in South-east Asia, mainly in children. Bleeding is known to result from impaired platelet function. This paper reports seven previously healthy young adults from Singapore who exhibited this syndrome. Bleeding was confined mainly to the skin and mucosal surfaces; no unusual clinical findings were noted. The bleeding tendency was transient. Intestinal helminths were found in four cases; five were mildly thrombocytopenic at onset. Platelet aggregation abnormalities were transient and the pattern suggested storage pool disease; this is discussed in relation to recent studies of the syndrome. The possible pathogenic role of eosinophilia and parasitism is also discussed.

Adult↗
PubMed1984

Testosterone, erythropoietin and anaemia in patients with disseminated bronchial cancer.

In 21 newly diagnosed male patients with disseminated bronchial cancer, anaemia was associated with a reduced serum concentration of testosterone. Erythropoietin levels were increased in anaemic patients. The results suggest a normal erythropoietin response to anaemia in this condition. The reduced testosterone concentration is associated with normal levels of luteinizing hormone and its significance in the pathogenesis of the anaemia is uncertain.

Adult↗
PubMed1984

Anemia in male adolescents in Singapore.

Among 990 young male adolescents studied, only 7 were anemic. Three of the anemics had beta-thalassemia trait and 4 had probable alpha-thalassemia trait. Forty-six individuals with hemoglobinopathies were detected: 29 with probable alpha-thalassemia trait, 10 with beta-thalassemia trait and 7 with heterozygous HbE. Heterozygous alpha and beta-thalassemia occurred predominantly in Chinese while heterozygous HbE was found entirely in Malays. There were no cases of established iron deficiency anemia and only 1 had iron deficient erythropoiesis. Folate deficiency occurred only in 8 subjects with thalassemia traits, and no vitamin B12 deficiency was detected.

Adolescent↗
PubMed1984

Circulating inhibitors.

Non-specific circulating inhibitors detected in 13 patients did not result in significant bleeding episodes. Five non-haemophiliacs who had inhibitors to Factor VIIIC did not have any underlying disorders but all of them experienced major bleeding episodes. Five per cent of haemophiliacs developed antibodies to Factor VIIIC. Most of them had severe haemophilia, but as the titres of antibody were low, they did not present with problems in management. Current modes of treatment for haemophiliacs with Factor VIIIC inhibitors include inducement of immune tolerance with high doses of Factor VIII, activated or non-activated prothrombin complex concentrate and plasmapheresis.

Adolescent↗
PubMed1984

Inhibition of erythroid colony growth in vitro by serum from patients with disseminated bronchial cancer.

The anemia of malignancy is characterized by a reduced output of erythroid cells but with a normal red cell survival. In this study, clonal assays of normal human marrows in the presence of serum from 13 patients with bronchial cancer gave significantly reduced yields of erythroid colonies compared with control cultures with normal serum. More than half the cultures showed no growth of either CFU-E or BFU-E. Four sera producing marked depression of erythroid colony growth had no effect on CFU-GM. The evidence suggests the presence of a circulating inhibitor that may be found in either anemic or nonanemic patients.

Adult↗
PubMed1984

Iron status in blood donors.

The iron status of 592 blood donors was analysed. The reduction in iron stores was related to the frequency rather than the total number of donations. 8% had reduced iron stores but this was not related to blood donation, iron supplementation and sex of the donors. Serum ferritin rather than haemoglobin, serum iron and transferrin saturation is the most reliable indication of iron status of blood donors. Iron supplementation did not confer any benefits.

Blood Donors↗
PubMed1982

Anaemia in patients with myelomatosis.

Twenty-four untreated patients with myelomatosis were studied in order to characterize their anaemia, using standard haematological and ferrokinetic techniques, together with measurements of circulating erythropoietin, erythropoietin sensitivity of marrow cultures and in vitro measurements of haem synthesis. There is a reduction in total erythroid output by the marrow, together with a minor degree of plasma expansion. In patients with normal renal function there is an appropriate increase in erythropoietin in response to anaemia, but in a few cases there may be reduced response of CFU-E to the hormone in vitro. No abnormality of iron status or haem synthesis was found. One case of folate deficiency was discovered.

Adult↗