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Biomedical subjects

W Cendrowski

Publications and source records attributed to W Cendrowski.

At least 19 recordsLinked to original sources
PubMed2001

[Therapeutic potential of interferon beta-1b and related drugs in multiple sclerosis: comparative meta-analysis].

The objective of this current meta-analysis is to determine whether IFN beta-1b is substantially better than other immunomodulating, immunosuppressive or anti-inflammatory drugs in modifying the clinical course of relapsing-remitting and secondary progressive multiple sclerosis (RR MS, SP MS). A comparison shows that in 2-year treatment IFN beta-1b, beta-1a s.c., glatiramer acetate, immunoglobulin G i.v. and mitoxantrone i.v. reduced annual relapse rate (45%), increased the proportion of relapse-free patients (34%), decreased the mean level of disability (-0.23 in EDSS) and diminished the fraction of RR MS patients with sustained progression (25%); p < or = 0.05. Azathioprine demonstrated considerable delay in the onset of action and loss of efficacy in the third year of treatment. IFN beta-1b and cyclical pulses of intravenous high dose methylprednisolone decreased the annual relapse rate and slowed the progression in SP MS patients; p < or = 0.04. All drugs significantly reduced the number of new and enlarging brain lesions on GdT1 and PD/T2 images in MRI (mean -68%). Furthermore, IFN beta-1b s.c. and beta-1a s.c. evidently reversed burden of the disease (BOD) on T2 images (median -4.7%); p = 0.001. However, glatiramer acetate, immunoglobulin G i.v., IFN beta-1a i.m., methylprednisolone i.m. and possibly azathiopirine failed to diminish BOD on T2 images; p = ns. It is concluded that in most RR MS patients IFN beta-1b has similar clinical effect to other immunomodulating drugs and mitoxantrone.

Adjuvants, Immunologic↗
PubMed1997

[Leukotrienes B4 and C4 in cerebrospinal of patients with multiple sclerosis].

Leukotrienes B4 and C4 have been assayed in CSF of 24 patients with the attacks or slowing-progressing course of multiple sclerosis, and in 23 patients with other noninflammatory diseases. Leukotrienes concentrations have been assayed with RIA technique with the use of commercially available kits manufactured by Amersham. Leukotrienes B4 and C4 levels in CSF of patients with multiple sclerosis have been 91.8 +/- 5.6, and 88.6 +/- 7.5 pg, and have been significantly higher than those in other neurological disorders (p < 0.01). Mean LTB4 and LTC4 levels have been significantly lower in patients with atherosclerotic dementia (69, 12.2 and 63, 02.9 pg/ml) or in patients with headache (72.7 +/- 2.8 and 64.5 +/- 8.2 pg/ml). Higher LTB4 and LTC4 levels in patients with multiple sclerosis is probably due to both increased penetration through blood-brain barrier and their synthesis in blood-brain barrier, and cerebral nervous tissue. Further investigations are necessary to show whether LTB4 and LTC4 levels may indicate a stage of inflammatory process activity and enable to draw any conclusions on efficacy of anti-inflammatory therapy.

Blood-Brain Barrier↗
PubMed1991

[Diagnosis and etiopathogenesis of retinitis in patients with multiple sclerosis].

Presented are: the incidence, symptomatology and diagnostics together with electroretinography of retinal periphlebitis as well as retinitis and maculopathy in patients with multiple sclerosis. Particular attention is called to the histopathology of the retina in this disease. The etiopathology of retinitis and maculopathy in multiple sclerosis is still unknown. Four etiopathological hypotheses are shortly discussed.

Electroretinography↗
PubMed1990

Temporary chromatopsia and alternate umbropsia in multiple sclerosis.

Uncommon visual symptoms were described in two women with clinically definite, remittent multiple sclerosis. In the first case with right optic atrophy temporary chromatopsia (vision of only blue colour) and left-sided, paroxysmal and alternate "fading out" followed by "brightening up" vision (umbropsia) occurred spontaneously. In the second case with bilateral optic atrophy transient chromatopsia (vision of only green colour) and short-lived "fading out" vision when fixating on a target were noted. Chromatopsia might be associated with impaired function of selected optic nerve fibers conducting impulses from a limited population of retinal ganglion cells. Alternate umbropsia and short-lived "fading out" vision probably depend on paroxysmal, frequency-related intermittent conduction block at the level of optic nerve fibers or synaptic elements.

Adolescent↗
PubMed1989

[Free fatty acids in the serum of patients with alcoholism].

Blood free fatty acids and their composition were investigated in 25 alcohol abusers hospitalized for detoxication. Blood samples were collected at the admission to the hospital and following detoxication therapy. Free fatty acids were assayed with Dole's technique whereas their composition with gas chromatography. Liver functioning was evaluated with the aid of the following tests: AspAT, AlAT, AP, bilirubin concentration, and thymol test. An increase in free fatty acids concentration was seen in 12 out of 25 patients prior to detoxication. Blood serum free fatty acids were within normal limits in all except one patient after detoxication. A decrease in linoleic acid levels was seen in both total fatty acids and free fatty acids before detoxication. It is more marked in total fatty acids than in free fatty acids and persists after detoxication. Linoleic acid content in free fatty acids returns to the normal values following detoxication. An increase in oleic acid level accompanying a decrease in linoleic acid concentration is probably secondary to the stimulation with hydrogen excess formed during alcohol fermentation.

Adult↗
PubMed1989

[Multiple sclerosis and psoriasis].

Among 51 patients with clinically probable multiple sclerosis three had typical chronic psoriasis. The incidence of psoriasis in the studies group of multiple sclerosis patients was higher (one case per 17 patients) than in the general population (one per 33 subjects). In all three cases psoriasis developed before the beginning of remitting multiple sclerosis and showed no correlation with the exacerbations of the neurological disease or with the degree of neurological function loss. The presence of histocompatibility antigens (HLA), immunopathological and biochemical changes in both diseases is discussed.

Adult↗