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Biomedical subjects

W Colin

Publications and source records attributed to W Colin.

10 recordsLinked to original sources

[Diagnostic value of computer-based endoscopy system].

OBJECTIVE: To assess the roles of computer-based endoscopy system as a clinical tool in evaluation of laryngeal disorder. METHOD: An extensive research of 100 patients under stroboscopy examination with acoustic and EGG signal was made, and a number of quantitative information, such as contact quotient, glottal noise and glottal area changes, was examined. RESULT: Quantitative information contributes significant diagnostic information in 14 cases, resulted in avoidance of surgery in 6 cases and 8 cases referred to surgery instead of voice and medical therapy. CONCLUSION: Acoustic and EGG measures should be used as substantially complements of endoscopy examination in the routine clinical examination.

Glottis↗

Fire in the operating room during tracheostomy.

BACKGROUND: Fire in the modern operating room is still a constant danger today despite the usual absence of the historically explosive anesthetic gases, cyclopropane, and ether. During a tracheostomy, three conditions are present that will support an explosive or combustive event: heat, fuel and oxygen. METHODS: We report three routine tracheostomy cases during which a fire was ignited. One patient had a minor burn during the cauterizing of a bleeding vessel. There was a visible flame in all cases and, in one case, the cloth drapes ignited. There were no serious airway injuries to any patients and all had a complete and uneventful recovery. We duplicated the same conditions in our laboratory. RESULTS: We discuss each case and give effective techniques to prevent ignition during surgery in the future. For our study, we reproduced flames in a cadaver trachea using halothane and the electrocautery in an oxygen-rich environment. We describe a protocol that has effectively prevented tracheostomy fires in our institution and may decrease the risk during other procedures as well. Also, we reviewed the literature to provide insight into the magnitude of the problem. CONCLUSIONS: High-oxygen concentration, the presence of fuels such as suture and tissue, and an igniting spark from the electrocautery device produce the proper conditions for a fire during tracheostomy. Taking the proper precautions can minimize if not eliminate this risk.

Adolescent↗

Conduction velocity of the human inferior alveolar nerve: a preliminary report.

This preliminary report describes a technique to consistently record electrophysiological signals from the uninjured inferior alveolar nerves of human subjects. Bilateral recordings were obtained from 15 consecutive human volunteers. The mean conduction velocity was 67.6 m/s, with no differences shown for right or left sides or gender. Conduction velocity testing could offer a new objectivity in the clinical study of the inferior alveolar nerve, aiding in the documentation, diagnosis, management, and follow-up of the sometimes complex neural lesions that oral and maxillofacial surgeons routinely see.

Adult↗

Trigeminal intraoral schwannomas.

This article clinically and histologically details four cases of schwannoma presenting in uncommon intraoral locations. The diagnosis and conservative management of these benign, encapsulated lesions are discussed. The association of intraoral schwannomas with multiple endocrine neoplasia syndrome 111 (MENS 111) and the need to rule out neurofibromatosis are noted.

Adolescent↗

Fluorescent latex microspheres as a retrograde tracer in the peripheral nervous system.

Rhodamine labeled latex microspheres were used as a fluorescent retrograde tracer in the peripheral nervous system. Examination of rabbit trigeminal ganglia following application of microspheres to crushed or intact inferior alveolar nerve revealed that: (1) microspheres were taken up by only damaged axons; (2) microspheres remained in trigeminal cell bodies for up to 3 months without degradation or diffusion to extracellular structures; and (3) cells containing microspheres were capable of regenerating axons as evidenced by the return of evoked sensory action potentials and the retrograde axonal transport of True blue. Thus, fluorescent microspheres may be useful tools for in vivo survival studies of peripheral nervous system regeneration and development.

Action Potentials↗

Nerve regeneration through collagen tubes.

Severe nerve injuries may require microsurgical grafting to span a defect. Introduction of graft material into a highly vascular recipient bed is documented to aid in early regeneration of neuronal blood supply. A silicone rod (SR)-induced fibrovascular sheath was employed to evaluate the regeneration of rat tibial nerve through 2-mm-diameter collagen tubes (CT) or contralateral nerve autografts (AUTO). At first operation, 5 mm of right tibial nerve was resected from 30 retired male breeder Sprague-Dawley rats. Resected nerve was replaced with either a 5 X 2 mm SR or the nerve ends were sutured to the intermuscular fascia. Four weeks later, animals were repaired by replacing the SR with either a CT or a contralateral AUTO from the left tibial nerve. Three months later, EMG testing was performed, and histologic sections were prepared. The EMG latency and the size of the compound action potential for sheathed or non-sheathed CT or AUTO were statistically superior to controls at the 95% confidence level. All other intergroup comparisons of latency and action potential size were statistically insignificant. The proportion of nerve fibers traversing the surgical sites was not influenced by the method of repair or by the presence or absence of sheathing. Tubulized repairs most closely resembled unoperated nerves, and autografted repairs had a large diameter, but much fibrosis, whereas controls displayed immaturity and disorganization. Our observations suggest that there was no difference between repairs performed with or without a vascular pseudosheath. However, CT supported regeneration better than did AUTO repair.

Action Potentials↗