Biomedical subjects

W Czarnecki

Publications and source records attributed to W Czarnecki.

39 records · Page 3Linked to original sources

PubMedDate not supplied

Effect of carriers and hydrophilic agents on papaverine spheres bioavailability.

The effect of carriers--potato starch, sodium carboxymethyl cellulose, sodium alginate, and hydrophilic agents--polyethyleneglycol 1500 (PEG 1500), PEG 4000, glyceryl monostearate (MSG), Tween 65, on bioavailability of papaverine from spheres were studied on rabbits. The data of pharmacokinetics parameters as absorption lag time, maximum plasma concentration (Cmax), time to peak concentration, absorption rate constant, elimination rate constant, bioavailability (F) depend on drug-carrier-hydrophilic agent composition. Potato starch-PEG 4000, potato starch-MSG, NaCMC-PEG 1500 spheres show best F-parameters of papaverine respectively 96%, 89%, 88%, Cmax 19.7, 21.3, 18.6 micrograms/ml reached in about 2 h.

Animals↗

PubMedDate not supplied

Disintegration rate and release of aminophenazone from tablets.

Disintegration apparatus according to P.Ph was adepted to measure the disintegration rate of tablets. The data obtained for 10 batches of aminophenazone tablets with different content of gelatine (2-20%) showed that there is a linear correlation between the area under non-disintegrated tablets mass curves (AUDC) and the area under release curves (AURC) described by equation: AUDC = bcr AURC - acr.

Aminopyrine↗

PubMedDate not supplied

Effect of processing technique of different dosage forms on dissolution rate of caffeine and salicylamide.

The dissolution rate of caffeine (Cf) and salicylamide (SA) from the mixtures of powders, granulate and tablets, obtained by the direct compression and wet granulation methods, has been investigated. The results presented in plots show, that the dissolution process of Cf and SA follows the first-order kinetics. The kinetic equations are used for the calculation of the dissolution rate contants (K) for the compounds of different solubility. Chromatography did not give an evidence for the formation of an adduct of Cf and SA in the granulate and tablets prepared by the wet granulation method.

Caffeine↗