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Biomedical subjects

W D Barker

Publications and source records attributed to W D Barker.

16 recordsLinked to original sources
PubMed2006

A study of the use of Ephedra in the manufacture of methamphetamine.

The Ephedra plant has been identified as an excellent source of ephedrine and pseudoephedrine, both of which can be chemically reduced to form the widely abused illicit drug methamphetamine. Ephedra contains several additional alkaloids that undergo analogous reductions to form amphetamine and N,N-dimethylamphetamine (also drugs of abuse). The main alkaloids obtained from the Ephedra plant have been reduced using four common methods used by the clandestine operator. The intermediates and byproducts of these reductions have been identified and/or tentatively assigned and the mechanism of formation discussed.

Journal Article↗
PubMed1980

Acute cholecystitis following the surgical treatment of spinal deformities in the adult: a report of three cases.

Acute cholecystitis following the surgical treatment of spinal deformities in the adult is reported in three cases. Although acute cholecystitis is not a rare postoperative complication, it is relatively unknown to orthopedic surgeons and has been seldom reported in the orthopedic literature. A review of the literature dealing with the pathogenesis and clinical manifestations reveals that postoperative cholecystitis is a life-endangering complication which should be promptly recognized. The occurrence of upper quadrant abdominal pain, accompanied by fever, tachycardia and signs of peritoneal irritation after any major orthopedic procedure, should alert the surgeon to the possibility of postoperative cholecystitis. Considering the high incidence of gangrene and perforation of the gallbladder, cholecystectomy is the treatment of choice.

Acute Disease↗
PubMed1978

Cost containment and the trustee.

Of all the challenges facing hospital trustees, the cost issue is the most pressing. Hospital costs can be contained through greater attention to productivity, more effective clinical patterns of practice, and better education of the hospital's various publics. Trustees can help to contain costs in their hospitals by supporting their administrators' cost containment efforts and by sharing their expertise with them.

Costs and Cost Analysis↗
PubMedDate not supplied

An ultrastructural evaluation of the effect of hydrocortisone on rabbit cartilage.

Pharmacologic and supra-pharmacologic doses of hydrocortisone acetate did not effect ultrastructural alteration of chondrocytes in articular cartilage of mature rabbits. Early biomechanical alterations are unaccompanied by ultrastructural cytological changes. Not until advanced biochemical alteration is effected by large, repetitive doses, does the ultrastructural alteration begin.

Animals↗